Retinal Diseases and Treatments

GENE EXPRESSION WITHIN A HUMAN CHOROIDAL NEOVASCULAR MEMBRANE USING SPATIAL TRANSCRIPTOMICS

This study uses spatial transcriptomics to analyze gene expression in a human choroidal neovascular membrane and identifies dysregulated genes and potential upstream regulators.

Retinoid X Receptor activation prevents diabetic retinopathy in murine models.

This study shows that RXR activation with UAB126 reduces hyperglycemia and improves retinal function in diabetic mice.

The glucocorticoid receptor as a master regulator of Mueller cell gliosis in the diabetic retina

The paper identifies the glucocorticoid receptor as a master regulator of Muller cell gliosis in diabetic retinopathy and shows that increasing GR expression can improve retinal function.

3D human retinal organoid model for the study of early diabetic retinopathy

This paper develops a 3D human retinal organoid model to study early diabetic retinopathy and identifies molecular and cellular features associated with the disease.

Spatial Distribution of Missense Variants within Complement Proteins Associates with Age Related Macular Degeneration

The paper analyzes missense variants in complement genes to identify spatial associations with AMD risk using structural and functional metrics.

Multityrosine Kinase Inhibitors Alleviate Laser-Induced Choroidal Neovascularization in Non-Human Primates: A Novel Therapy for Diabetic Retinopathy and Age-Related Macular Degeneration

This study shows that Cabozantinib reduces laser-induced choroidal neovascularization in non-human primates without toxicity, suggesting it as a potential therapy for AMD and DR.

Knockout of AMD-associated gene POLDIP2 reduces mitochondrial superoxide in human retinal pigment epithelial cells

This study shows that knocking out POLDIP2 in human RPE cells reduces mitochondrial superoxide levels, linking POLDIP2 to oxidative stress in AMD.

Melanin Nanoparticles as an Alternative to Natural Melanin in Retinal Pigment Epithelium Cells and Their Therapeutic Effects against Age-Related Macular Degeneration

This study demonstrates that PEGylated-synthetic melanin nanoparticles can substitute for natural melanin in retinal pigment epithelium cells and provide antioxidant protection against oxidative stress in age-related macular degeneration.

Transcriptomic and proteomic retinal pigment epithelium signatures of age-related macular degeneration.

This study identifies genetic and molecular differences in RPE cells from geographic atrophy patients compared to controls using transcriptomic and proteomic analyses.

Age-related Macular Degeneration patient deep phenotyping and whole genome sequencing analysis identifies coding variants linking small low-luminance visual deficit to fat storage defects

The paper identifies coding variants in the CIDEC gene associated with small low-luminance visual deficit in AMD patients, showing an indirect effect on fat storage and lipid droplet fusion.

A Proteogenomic Signature of Age-related Macular Degeneration in Blood

This study identifies a proteogenomic signature in blood associated with age-related macular degeneration, linking serum proteins to disease severity and progression.

Retinal aging transcriptome and cellular landscape in association with the progression of age-related macular degeneration

This study analyzes the transcriptome and cellular landscape of aging retinas in AMD patients and controls, identifying age-related genes and cellular changes associated with AMD progression.

MicroRNA-143 plays a protective role in ischemia-induced retinal neovascularization

The paper identifies miR-143 as a protective miRNA in ischemia-induced retinal neovascularization using miRNA-Seq and RNA-Seq in a rat model.

Endothelial Caspase-9 Promotes Glial Changes, Inflammation, and Contrast Sensitivity Decline in Retinal Vascular Injury

This study shows that endothelial caspase-9 modulates glial reactivity, inflammation, and visual function decline in retinal vascular injury.

tiRNA-Val promotes angiogenesis via Sirt1-Hif-1α axis in mice with diabetic retinopathy

The paper identifies tiRNA-Val as a regulator of angiogenesis in diabetic retinopathy by modulating the Sirt1-Hif-1α axis in mice.

Melanosomes degrade lipofuscin and precursors that are derived from photoreceptor membrane turnover in the retinal pigment epithelium--an explanation for the origin of the melanolipofuscin granule

This study shows melanin in RPE cells helps degrade lipofuscin and its precursors, reducing MLF granules in pigmented mice but not in albino mice.

OCTA observation of changes in macular vessel density in diabetic patients and its correlation with diabetic retinopathy staging

This study examines the correlation between OCTA vessel density and diabetic retinopathy staging in diabetic patients, finding moderate correlations with superficial and deep vessel density and AI/FD indices.

Comparative transcriptome analysis of human and murine choroidal neovascularization identifies fibroblast growth factor inducible-14 as phylogenetically conserved mediator of neovascular age-related macular degeneration

The paper compares transcriptomes of human and mouse choroidal neovascularization to identify FN14 as a conserved mediator of neovascular AMD.

mTOR inhibition via Rapamycin treatment partially reverts the deficit in energy metabolism caused by FH loss in RPE cells

This study shows that mTOR inhibition with rapamycin partially rescues metabolic defects in RPE cells caused by CFH loss, suggesting a link between intracellular FH and the ubiquitin-proteasomal pathway.

Identification of Dysregulated Pathways and key genes in Human Retinal Angiogenesis using Microarray Metadata

The paper identifies dysregulated pathways and key genes in retinal angiogenesis using microarray data from PDR, ROP, and nAMD, revealing cytokine-cytokine receptor interaction as a significant pathway.

Identification of age-associated proteins and functional alterations in human primary retinal pigment epithelium cells

The paper identifies age-associated proteins and functional changes in human retinal pigment epithelium cells using proteomic analysis and validation.

Age-Related Changes in the Rhesus Macaque Eye

This study examines age-related changes in rhesus macaque eyes and compares them to human age-related eye diseases, finding similarities in intraocular pressure, retinal structure, and macular lesions.

Complement C5 is not critical for the formation of sub-RPE deposits in Efemp1 mutant mice.

This study shows that C5 ablation does not prevent sub-RPE deposit formation in Efemp1 mutant mice, suggesting C3, not C5, may be a better therapeutic target for early AMD.

Mitochondria-dependent phase separation of disease-relevant proteins drives pathological features of age-related macular degeneration

This study identifies mitochondrial stress-mediated protein phase separation as a key pathogenic mechanism in AMD, linking genetic risk factors to RPE dysfunction.

Grp78 alleviates sodium iodate-induced retinal cell injury in vivo and in vitro

This study shows Grp78 protects retinal cells from sodium iodate-induced injury in both in vitro and in vivo models by reducing ROS and apoptosis.

Genetic Disruption of Serine Biosynthesis is a Key Driver of Macular Telangiectasia Type 2 Etiology and Progression

This study identifies serine biosynthesis as a key driver of MacTel etiology and progression using statistical genetics methods.

Reduction of Glut1 in retinal neurons but not the RPE alleviates polyol accumulation and normalizes early characteristics of diabetic retinopathy.

This study shows that reducing Glut1 in retinal neurons, but not the RPE, reduces polyol accumulation and prevents early diabetic retinopathy features in mice.

Oxidative stress alters transcript localization of disease-causing genes in the retinal pigment epithelium

The paper investigates how oxidative stress affects transcript localization in retinal pigment epithelium cells using RNA sequencing.

Genome-wide association meta-analysis for early age-related macular degeneration highlights novel loci and insights for advanced disease

This study performs a genome-wide association meta-analysis of early AMD, identifying 11 loci, 9 novel, and highlighting shared and distinct genetic factors between early and advanced AMD.

Functional study of the AMD-associated gene TMEM97 in retinal pigmented epithelium using CRISPR interference

This study uses CRISPR interference to show that TMEM97 knockdown protects ARPE19 cells from oxidative stress-induced death, supporting its role in AMD pathobiology.