Pregnancy and preeclampsia studies

Gestational Chronic Intermittent Hypoxia Triggers Maternal Inflammation and Disrupts Placental Stress Responses

This study shows that gestational chronic intermittent hypoxia increases maternal inflammation, alters EV characteristics, and disrupts placental stress responses in rats without affecting fetal growth.

Liposomal encapsulation of L-arginine and L-citrulline enhances therapeutic effects in a rat model of Preeclampsia and Fetal Growth Restriction

This study shows that liposomal encapsulation of L-arginine and L-citrulline improves pharmacokinetics and reduces maternal blood pressure in a rat model of Preeclampsia and Fetal Growth Restriction.

TGFb-induced SMAD1/5 activation drives transient epithelial-to-mesenchymal transition in trophoblasts

This study identifies TGFβ-induced SMAD1/5 activation as critical for transient EMT in trophoblasts, linking it to placental development and preeclampsia.

Aberrant placental structure is corrected with repeated nanoparticle-mediated IGF1 treatments in a guinea pig model of fetal growth restriction

This study shows repeated nanoparticle-mediated IGF1 treatment corrects aberrant placental structure in a guinea pig model of fetal growth restriction, improving fetal growth and placental function.

Spatially resolved fetal and maternal cell contributions to severe Preeclampsia

This study identifies spatially distinct fetal and maternal cell contributions to severe preeclampsia, highlighting new maternal immune signatures and potential therapeutic targets.

Compensatory placental hypervascularization in a rat model of early-stage, diet-induced maternal obesity

This study shows that short-term maternal obesity in rats leads to increased placental vessel density, indicating compensatory hypervascularization before systemic metabolic disease.

Maternal smoking in early pregnancy disrupts placental function through syncytiotrophoblast and macrophage dysregulation.

This study shows maternal smoking disrupts placental function by altering syncytiotrophoblast and macrophage biology, leading to fetal growth restriction.

Maternal high-fat, high-sucrose diet-induced excess adiposity is linked to placental hypoxia and disruption of fetoplacental immune homeostasis in late gestation

This study shows that maternal high-fat, high-sucrose diet leads to placental hypoxia and immune disruption in late gestation without significant fetal growth issues.

SARS-CoV-2 infection disrupts syncytial and endothelial integrity and alters PLGF levels in the placenta

This study shows SARS-CoV-2 infection in placental tissues increases syncytial knots and alters PlGF levels, similar to preeclampsia features.

The genetic origin of fetal growth restriction and mitochondrial complex I dysregulation

This study identifies SNPs in the nuclear genome associated with fetal growth restriction and mitochondrial complex I dysfunction, impacting placental bioenergetics and birthweight.

Placental Iron Utilisation in Fetal Growth Restriction: Alterations in Mitochondrial Heme Synthesis and Iron-Sulfur Cluster Assembly Pathways

This study investigates iron utilization in placental tissues of fetal growth restriction (FGR) pregnancies, revealing increased iron uptake and prioritization of heme synthesis over iron-sulfur cluster formation.

VGLL3-centered network connects placental, vascular, and immune defects in preeclampsia

This study identifies VGLL3 as a key driver of preeclampsia by linking it to placental, vascular, and immune defects, showing its therapeutic potential through genetic and pharmacological inhibition.

Perinatal Asphyxia Alters Physiological Responses and Ex Vivo Cardiovascular Function of Preterm Growth-Restricted Lambs

This study shows that preterm growth-restricted lambs have altered cardiovascular responses to perinatal asphyxia, including impaired vascular contractility and dysregulated adrenergic receptor function.

New insights into the role of oxytocin signaling in preeclampsia

This study investigates oxytocin signaling's role in preeclampsia by analyzing placental and plasma samples, revealing its association with placental dysfunction and potential as an early diagnostic biomarker.

The piRNA PETPIR Regulates Trophoblast Function by Modulating YTHDF2-Mediated m6A Methylation of NDRG1 in Preeclampsia

The paper identifies PETPIR as a regulator of trophoblast function in preeclampsia by modulating m6A methylation of NDRG1 via YTHDF2.

A human cytotrophoblast-villous endothelium-fetal organ multi-cell model and the impact on gene and protein expression in placenta cytotrophoblast, fetal hepatocytes and fetal kidney epithelial cells

This study examines the effects of trophoblast stress and hIGF1 nanoparticle gene therapy on gene and protein expression in fetal liver and kidney cells using a co-culture model.

Pregnancy-Dependent Cardioprotection via GPER Activation in Dahl Salt-Sensitive Rats

This study shows that GPER agonist LNS8801 improves cardiac function in pregnant Dahl SS/Jr rats but not virgin rats, highlighting pregnancy-specific cardioprotective effects.

Placental cytotrophoblast microvillar stabilization is required for cell-cell fusion

The paper identifies microvillar stabilization via ezrin as essential for cytotrophoblast fusion and differentiation in the placenta.

Cytokine-driven cellular polarization in preeclampsia revealed through the "Dictionary of immune responses"

The paper identifies cytokine-driven cellular polarization in preeclampsia using single-cell sequencing and machine learning, revealing altered immune cell states and potential therapeutic targets.

Decreased Extracellular Vesicle Vasorin in Severe Preeclampsia Plasma Mediates Endothelial Dysfunction

This paper identifies decreased vasorin (VASN) in extracellular vesicles (EV) of severe preeclampsia (sPE) plasma as a mediator of endothelial dysfunction, showing VASN's role in vascular function and its potential as a biomarker and therapeutic target.

Altered placental morphology and metabolomic profile in as-sociation with uncomplicated metabolically healthy obese pregnancy

This study identifies altered placental morphology and metabolomic profiles in metabolically healthy obese pregnancies, highlighting unique metabolic pathways and potential biomarkers.

Placental Malaria Induces a Unique Methylation Profile Associated with Fetal Growth Restriction

The paper compares methylation profiles of placentas with non-malarial and PM-associated FGR, finding distinct differentially methylated CpGs and a shared hypomethylated site in BMP4.

Plasma, not extracellular vesicles, disrupts the blood-brain barrier in eclampsia.

This study shows that plasma, not extracellular vesicles, disrupts the blood-brain barrier in eclampsia, and magnesium sulfate reduces this effect by decreasing vesicle uptake and altering their protein content.

Quantifying Molecular Changes in the Preeclamptic Rat Placenta with Targeted Contrast-Enhanced Ultrasound Imaging

This study uses a bicompartmental model to quantify molecular changes in the placenta of preeclamptic rats using targeted contrast-enhanced ultrasound imaging.

Genetically edited human placental organoids cast new light on the role of ACE2 in placental development

This study uses gene-edited placental organoids to show that ACE2 knockout causes delayed growth and increased cell death, while the ACE2 rs2074192 TT genotype increases ACE2 expression but reduces enzyme activity.

microRNA-Mediated Effects of Caloric Restriction on Trophoblast Invasion and Angiogenic Signaling in a Mouse Model of Fetal Growth Restriction

This study shows that caloric restriction in mice leads to placental dysfunction through miR-503-5p upregulation, which inhibits trophoblast invasion and angiogenesis genes.

General model with biclustering for target selection in severe preeclampsia

The paper develops a biclustering regression model to identify key genes and their relationships with clinical phenotypes in severe preeclampsia, recommending 81 potential druggable targets.

Characterization of cytotrophoblast cell population dynamics throughout pregnancy

This study characterizes cytotrophoblast dynamics during pregnancy using single-cell RNA sequencing, identifying distinct subsets and their functional roles.

Placental Nutrient Transport and Signaling in a Guinea Pig Model of Fetal Growth Restriction with Repeated Placental Nanoparticle-mediated IGF1 Treatment

This study investigates placental IGF1 signaling and nutrient transport in a guinea pig model of FGR with nanoparticle-mediated IGF1 treatment, showing sex-specific changes and supporting therapeutic potential.

Mid-pregnancy placental transcriptome in a model of placental insufficiency with and without novel intervention

This study examines placental transcriptome changes in a guinea pig model of placental insufficiency with and without hIGF1 nanoparticle treatment, identifying key signaling and metabolic pathways affected.