Pregnancy and preeclampsia studies

TFAP2C is a key regulator of intrauterine trophoblast cell invasion and deep hemochorial placentation

This study identifies TFAP2C as a critical regulator of trophoblast cell invasion and hemochorial placentation in rats, showing its role in both early development and later gestation.

Early prediction of preeclampsia using the first trimester vaginal microbiome

This study predicts preeclampsia using first trimester vaginal microbiome data with machine learning, achieving an auROC of 0.78 in the training set and 0.80 in an independent cohort.

Accumulation of Dietary and Non-Enzymatic Oxysterols in Preeclamptic Placentas: Insights into Cholesterol Dynamics in Pregnancy Complications

This study finds higher oxysterol levels in preeclamptic placentas compared to healthy pregnancies, suggesting altered cholesterol dynamics and oxidative stress in preeclampsia.

Early Prediction of Preeclampsia Based on Transposable Elements signature in cell-free RNA

This study identifies a transposable element (TE) signature in maternal cell-free RNA that predicts preeclampsia with high accuracy.

Diminished placental Factor XIIIA1 expression associates with long term ART and preterm birth in pregnant people living with HIV.

The paper links low placental Factor XIIIA1 expression with preterm birth in pregnant people living with HIV on long-term ART, suggesting ART may disrupt placental vascularization.

Maternal-fetal interfaces transcriptome changes associated with placental insufficiency and a novel gene therapy intervention

This study identifies transcriptome changes in the sub-placenta/decidua associated with placental insufficiency and shows that hIGF1 nanoparticle treatment alters gene expression related to trophoblast invasion and homeostasis.

Deciphering the Preeclampsia-Specific Immune Microenvironment: The Role of Pro-inflammatory Macrophages

This study identifies pro-inflammatory macrophages as key regulators of the PE-specific immune microenvironment, linking them to Th17 and CD8+ T cell activation and gMDSC suppression in placental tissues.

Genetic Predictors of Blood Pressure Traits are Associated with Preeclampsia

This study investigates the association between polygenic risk scores for blood pressure traits and preeclampsia, finding shared genetic architecture but no improvement in prediction models.

Single-cell transcriptomics reveal differences between chorionic and basal plate cytotrophoblasts and trophoblast stem cells

The paper uses single-cell RNA sequencing to compare transcriptional differences between chorionic and basal plate cytotrophoblasts and trophoblast stem cells in early human placenta.

Epigenetic changes regulating the epithelial-mesenchymal transition in human trophoblast differentiation

The paper identifies an epithelial-mesenchymal transition (EMT) mechanism in human trophoblast differentiation, linking DNA methylation changes to gene expression and invasion capacity.

Transcriptomic comparison of in vitro models of the human placenta

This study compares transcriptomes of in vitro human placental models to bulk placental tissue, finding significant gene expression differences and developing a web tool for model selection.

Placental extracellular vesicles from early-onset but not late-onset preeclampsia induce a pro-vasoconstrictive and anti-vasodilatory state in resistance arteries

This study shows that placental EVs from early-onset preeclampsia impair maternal vascular function, while those from late-onset preeclampsia have minimal effect.

Detection of early-onset severe preeclampsia by cell-free DNA fragmentome

This paper develops a machine-learning model using cfDNA fragmentation patterns to predict early-onset severe preeclampsia with high accuracy in early pregnancies and NIPT samples.

Preeclampsia in mice carrying fetuses with APOL1 risk variants

This study uses mouse models to show that fetal APOL1-G1 variants cause preeclampsia by inducing pro-inflammatory responses in placental and maternal monocyte cells.

Differential Expression of 5'-tRNA Fragments in Circulating Preeclampsia Syncytiotrophoblast Vesicles Drives Macrophage Inflammation

The paper identifies 5'-tRNA fragments in preeclampsia syncytiotrophoblast vesicles that drive macrophage inflammation and endothelial dysfunction.

Early spiral arteriole remodeling in the uterine-placental interface: a rat model

This study establishes a rat model to investigate early spiral arteriole remodeling in the uterine-placental interface, showing similar anatomical changes to humans before immune cell influx.

Polycomb Repressive Complex 1.1 Component, BCOR, Promotes Syncytiotrophoblast Differentiation in Mice and Humans

This study shows BCOR is essential for syncytiotrophoblast differentiation in mice and humans by repressing stem cell genes and alternate lineage factors.

High-throughput mRNA-seq atlas of human placenta shows vast transcriptome remodeling from first to third trimester

The paper constructs an mRNA-seq atlas of human placenta across gestation, identifying extensive transcriptome changes from first to third trimester.

Discovery and Verification of Extracellular microRNA Biomarkers for Diagnostic and Prognostic Assessment of Preeclampsia at Triage

This study identifies and validates three bivariate extracellular miRNA biomarkers for early diagnosis and subtype distinction of preeclampsia using maternal serum samples.

CONDITIONALLY MUTANT ANIMAL MODEL FOR INVESTIGATING THE INVASIVE TROPHOBLAST CELL LINEAGE

This paper develops a conditional rat model to study invasive trophoblast cell lineage regulation and its role in uterine spiral artery remodeling.

NOTCH3 signalling controls human trophoblast stem cell expansion and differentiation

This study shows that NOTCH3 signaling regulates human trophoblast stem cell expansion and differentiation, with implications for placental development and pregnancy disorders.

Genomic variation associated with cardiovascular disease progression following preeclampsia: A systematic review

This study reviews genomic studies on cardiovascular disease progression after preeclampsia, finding heterogeneity in approaches and outcomes but common use of case-control designs.

Low- and high-level information analyses of transcriptome connecting endometrial-decidua-placental origin of preeclampsia subtypes: A preliminary study

This study identifies transcriptome differences in endometrial maturation and placental chorioamnionitis that distinguish preeclampsia subtypes and highlight competing risks.

Genome-wide association study of placental weight in 179,025 children and parents reveals distinct and shared genetic influences between placental and fetal growth

This study identifies 40 genetic loci associated with placental weight using GWAS in 179,025 children and parents, revealing shared and distinct genetic influences with fetal growth.

NAD+ depletion and altered mitochondrial function are key to the establishment of placental dysfunction in an inflammatory-driven subclass of preeclampsia

Boosting NAD+ levels prevent inflammatory-driven preeclampsia by improving placental mitochondrial function.

GATA-regulated transcriptional program dictate cell fate equilibrium to establish the maternal-fetal exchange interface and fetal development

This study identifies GATA2 and GATA3 as critical regulators of trophoblast progenitor differentiation into syncytiotrophoblasts, essential for placental development and fetal viability.

GWAS of preeclampsia and hypertensive disorders of pregnancy uncovers genes related to cardiometabolic, endothelial and placental function

This study conducts a GWAS of preeclampsia and hypertensive disorders of pregnancy, identifying 18 genome-wide significant loci, including novel associations with blood pressure and placental function.

Upregulated GRP78 and sFlt-1 in preeclampsia induces IRE1 and ATF6 arms of UPR leading to ER stress in placental cells

The paper investigates the role of upregulated GRP78 and sFlt-1 in preeclampsia, showing their induction of IRE1 and ATF6 arms of UPR and ER stress in placental cells through in vitro experiments.

eoPred: Predicting the placental phenotype of early-onset preeclampsia using DNA methylation

eoPred predicts the placental phenotype of early-onset preeclampsia using a 45 CpG DNA methylation signature, showing high performance in cross-validation and validation cohorts.

Altered expression of MMP9 and TIMP1 leads to impaired placentation in early onset preeclamptic patients: a case control study

This study examines MMP-9 and TIMP-1 expression in placentae of early-onset preeclampsia patients compared to controls, finding altered expression levels associated with impaired placentation.