Hearing, Cochlea, Tinnitus, Genetics

Auditory Brainstem Mechanisms Likely Compensate for Self-imposed Peripheral Inhibition

The paper investigates how the brainstem compensates for peripheral inhibition in the auditory system using short stimuli and finds that brainstem inhibition diminishes with longer stimuli.

Increased Pyramidal and VIP Neuronal Excitability in Primary Auditory Cortex Directly Correlates with Tinnitus Behavior

This study identifies tinnitus-related changes in synaptic function of specific neuronal subtypes in an animal model, showing increased excitability in pyramidal and VIP neurons that correlate with tinnitus behavior.

Cellular reprogramming with ATOH1, GFI1, and POU4F3 implicate epigenetic changes and cell-cell signaling as obstacles to hair cell regeneration in mature mammals

This study shows that reprogramming mature mammalian cochlear cells with ATOH1, GFI1, and POU4F3 is hindered by epigenetic inaccessibility and cell-cell signaling, particularly Notch signaling.

Temporal masking and rollover in the neural code for speech with and without hearing loss

This study investigates how hearing loss affects neural encoding of speech, finding that temporal masking and rollover phenomena impact speech discrimination in both normal and hearing-impaired animals.

Kiaa1024L/Minar2 is essential for hearing by regulating cholesterol distribution in hair bundles

This study identifies Kiaa1024L/Minar2 as essential for hearing by regulating cholesterol distribution in hair bundles, showing that its loss causes deafness in zebrafish.

Preservation of prehearing spontaneous activityenables early auditory system development in deaf mice

The paper shows that in deaf mice lacking connexin 26, cochlear supporting cells retain spontaneous activity, preserving early auditory circuit development despite structural cochlear changes.

Electrical Signaling in Cochlear Efferents is Driven by an Intrinsic Neuronal Oscillator

The paper investigates electrical activity in lateral olivocochlear neurons, finding an intrinsic calcium-dependent oscillator that generates slow spike bursts, regulated by synaptic inputs.

Effects of sensorineural hearing loss on formant-frequency discrimination: Measurements and models

This study examines how sensorineural hearing loss affects formant-frequency discrimination by measuring thresholds and comparing them to auditory models.

Mechanisms of masking by Schroeder-phase harmonic tone complexes in the budgerigar (Melopsittacus undulatus)

This study investigates Schroeder-phase harmonic tone masking in budgerigars, finding that behavioral thresholds increase with masker F0 and show minimal C value differences, while neural responses exhibit asymmetry between opposite C values.

Auditory Brainstem Response as an Objective Measure of Temporal Resolution

The paper explores the relationship between behavioral temporal resolution tests and ABR latency parameters to provide an objective measure for assessing temporal resolution.

Prolonged dexamethasone exposure enhances zebrafish lateral-line regeneration but disrupts mitochondrial homeostasis and hair cell function

This study shows that prolonged dexamethasone exposure promotes lateral-line hair cell regeneration in zebrafish but impairs mitochondrial function and hair cell resilience to ototoxic stress.

Identification of putative GATA3 regulatory elements and comparison of GATA3 distribution in cochleae of mice, rats, macaques, and humans.

The paper identifies GATA3 regulatory elements and compares GATA3 distribution across species, finding conservation in cochlear cell types but a unique absence in human inner hair cells.

Relative changes in the cochlear summating potentials to paired-clicks predict speech-in-noise perception and subjective hearing acuity

The paper shows that exaggerated summating potentials to paired-clicks predict speech-in-noise perception and subjective hearing acuity in individuals at risk for cochlear synaptopathy.

Peripheral Auditory Nerve Impairment in a Mouse Model of Syndromic Autism

This study identifies peripheral auditory nerve impairment in a mouse model of MEF2C haploinsufficiency syndrome, linking AN dysfunction to ASD-related behaviors and immune cell involvement.

Repressor element 1-silencing transcription factor deficiency yields profound hearing loss through Kv7.4 channel upsurge in auditory neurons and hair cells

This study shows that REST deficiency leads to increased Kv7.4 channels in auditory neurons and hair cells, causing progressive hearing loss, which can be reversed by Kv7.4 inhibition.

Neural signatures of auditory hypersensitivity following acoustic trauma

This study shows that acoustic trauma leads to non-homeostatic gain changes in auditory cortex neurons, contributing to hypersensitivity to sound.

Cell-type-specific roles of inhibitory interneurons in the rehabilitation of auditory cortex after peripheral damage

The paper investigates how inhibitory interneurons contribute to auditory cortex plasticity after peripheral damage, revealing cell-type-specific roles in restoring sound processing.

A gap-junction mutation in the mouse cochlea reveals cochlear amplification is driven by outer hair cell extracellular receptor potentials

This study shows that a gap-junction mutation in mice preserves high-frequency hearing by maintaining extracellular receptor potentials in outer hair cells, suggesting these potentials drive cochlear amplification at high frequencies.

ISL1 is necessary for auditory neuron development and contributes towards tonotopic organization

This study shows that ISL1 is essential for auditory neuron development and tonotopic organization, but central plasticity cannot fully compensate for peripheral dysfunction.

Comprehensive simulation and interpretation of single nucleotide substitutions in GJB2 reveals the genetic and phenotypic landscape of GJB2-related hearing loss

The paper interprets all possible single-nucleotide substitution variants in the GJB2 gene, classifies them by pathogenicity, and identifies genotype-phenotype correlations in hearing loss.

Chronic neurotransmission increases the susceptibility of lateral-line hair cells to ototoxic insults

The paper shows that blocking neurotransmission in zebrafish hair cells reduces their susceptibility to ototoxic insults like neomycin by decreasing mitochondrial activity and ROS buildup.

Feasibility evaluation of transtympanic laser stimulation of the cochlea from the outer ear

This study evaluates infrared laser stimulation of the cochlea from the outer ear in Mongolian gerbils, showing it can bypass middle ear function and activate the cochlea noninvasively.

Early precision of radial patterning of the mouse cochlea is achieved by a linear BMP signaling gradient and is further refined by SOX2

This study shows that a linear BMP signaling gradient establishes radial patterning in the mouse cochlea, with SOX2 refining precision in specific regions.

Single-cell RNA-seq reveals stepwise fate conversion of supporting cells to hair cells in the chick auditory epithelium

The paper uses single-cell RNA sequencing to study fate conversion of supporting cells to hair cells in chick auditory epithelium, identifying a stepwise process involving precursor states and TGFβ signaling.

A regulatory network of Sox and Six transcription factors initiate a cell fate transformation during hearing regeneration in adult zebrafish

Expression of complexes I,II and IV decreased in noise-injured SGNs, mediating degeneration of SGNs

The paper investigates how noise injury affects mitochondrial function in spiral ganglion neurons (SGNs) by reducing expression of complexes II and IV, leading to delayed injury and degeneration.

Tbx2 is essential for cochlear inner hair cell development and regeneration

This study identifies Tbx2 as essential for inner hair cell development and shows that its co-expression with Atoh1 can reprogram supporting cells into functional inner hair cells.

Regulation of membrane homeostasis by TMC1 mechanoelectrical transduction channelsis essential for hearing

This study shows TMC1, but not TMC2, is essential for membrane remodeling in response to calcium changes, and mutations in TMC1 disrupt membrane homeostasis, leading to hearing loss.

Regulation of Auditory Sensory Neuron Diversity by Runx1

This study shows that Runx1 regulates the diversity of auditory sensory neurons in mice, influencing their subtype identities and functional properties through postnatal plasticity.

Cross-Species Experiments Reveal Widespread Cochlear Neural Damage in Normal Hearing

The paper reports widespread cochlear neural damage in normal-hearing individuals and animals using physiological assays, despite no clinical hearing loss.