Circadian rhythm and melatonin

Studies overestimate the extent of circadian rhythm reprogramming in response to dietary and genetic changes

The paper shows that Venn Diagram analysis overestimates differentially rhythmic transcripts and introduces an R-package to improve accuracy in circadian rhythm studies.

Cellular calcium levels influenced by NCA-2 impact circadian period determination in Neurospora

This study identifies NCA-2 as a regulator of circadian period length in Neurospora by modulating intracellular calcium levels and affecting core clock component phosphorylation.

TimeCycle: Topology Inspired MEthod for the Detection of Cycling Transcripts in Circadian Time-Series Data

TimeCycle detects cycling transcripts in circadian time-series data using topology-based methods, showing effectiveness across various sampling schemes and data conditions.

Core Circadian Clock Genes Per1 and Per2 regulate the Rhythm in Photoreceptor Outer Segment Phagocytosis

This study shows that Per1 and Per2 are required for the daily rhythm of photoreceptor outer segment phagocytosis, with the RPE driving this process transcriptionally.

Deletion of the Clock Gene Period2 (Per2) in Glial Cells Alters Mood-Related Behavior in Mice

This study shows that deleting Per2 in glial cells of mice alters mood-related behaviors, reducing despair and anxiety with changes in neurotransmitter levels.

Daily changes in neuronal activities of the dorsal motor nucleus of the vagus under standard and short-term high fat diet - implications for circadian modulation of parasympathetic outflow

The paper shows that DMV neuronal activity varies daily and is modulated by diet, with high-fat diets paradoxically increasing daily variation but reducing responsiveness to metabolic neuromodulators.

Likelihood-based Tests for Detecting CircadianRhythmicity and Differential Circadian Patterns in Transcriptomic Applications

This paper introduces likelihood-based methods to detect circadian rhythmicity and differential circadian patterns in transcriptomic data, showing improved error control and power in simulations and real data.

Daytime light enhances the amplitude of circadian output in a diurnal mammal

This study shows that higher daytime light intensity increases circadian rhythm amplitude in the diurnal rodent Rhabdomys pumilio by affecting SCN electrophysiological activity.

A Detailed Map of Coupled Circadian Clock and Cell Cycle with Qualitative Dynamics Validation

The paper creates a merged SBGN PD map of the circadian clock and cell cycle, validates its dynamics, and identifies NR1D1's role in regulating cell cycle progression.

Weekend light shifts evoke persistent Drosophila circadian neural network desynchrony

This study examines how a 3-hour weekend light shift disrupts circadian rhythms in Drosophila, leading to desynchrony in neural networks and behavioral defects.

Per1/Per2-Igf2 axis-mediated circadian regulation of myogenic differentiation

This study shows that Per1 and Per2 regulate myoblast differentiation and muscle regeneration through Igf2 activation, creating a circadian time window for these processes.

Diurnal transcript profiling of the diatom Seminavisrobusta reveals adaptations to a benthic lifestyle

This study profiles the diurnal transcriptome of the benthic diatom Seminavis robusta, revealing rhythmic gene expression patterns and adaptations to its environment.

Jetlag Expectations, not Circadian Parameters, Predict Jetlag Symptom Severity in Travelers

This study finds that travelers' expectations, not circadian factors like time zones crossed or travel direction, predict jetlag symptom severity.

Dopamine desynchronizes the retinal clock through a melanopsin-dependent regulation of acetylcholine retinal waves during development

Developmental Circadian Disruption Alters Placental Signaling in Mice

This study shows that developmental circadian disruption in mice alters placental gene expression and immune cell markers, potentially increasing adult chronic disease risk.

Temporally and Spatially Partitioned Neuropeptide Release from Individual Clock Neurons

The paper shows that Drosophila clock neurons release neuropeptides from different compartments at different times, with somatic release controlled by IP3 and terminal release by Ca2+.

Modeling the circadian regulation of the immune system: sexually dimorphic effects of shift work

This study models the circadian regulation of the immune system in shift workers, showing sex-specific effects on immune response to inflammation.

Daily rewiring of a neural circuit generates a predictive model of environmental light

The paper describes a model in flies that uses daily neural circuit rewiring to predict environmental light changes based on time-of-day.

A stochastic oscillator model simulates the entrainment of vertebrate cellular clocks by light

The paper develops a stochastic oscillator model to simulate how light entrains zebrafish circadian clocks and applies it to predict effects of pharmacological treatments on entrainment dynamics.

Blunted Diurnal Firing in Lateral Habenula Projections to Dorsal Raphe Nucleus and Delayed Photoentrainment in Stress-Susceptible Mice.

This study shows that stress-susceptible mice have blunted diurnal firing in LHb-DRN projections and slower photoentrainment, while resilient mice maintain normal rhythms and faster entrainment.

Light stimuli and circadian clock affect neural development in Drosophila melanogaster

The paper shows light and circadian clock impair neural stem cell growth and proliferation in Drosophila by affecting the InR/TOR pathway.

Drosophila clock cells use multiple mechanisms to transmit time-of-day signals in the brain

The paper identifies multiple mechanisms by which Drosophila clock neurons transmit time-of-day signals to the pars intercerebralis to regulate circadian behaviors.

Cell type resolved co-expression networks of core clock genes in brain development.

This study identifies co-expression networks of core clock genes in different cell types during brain development using single-cell RNA sequencing data.

The circadian oscillator analysed at the single-transcript level

The paper measures single-cell mRNA dynamics of core-clock genes in mouse fibroblasts and develops a probabilistic model to decompose mRNA variability, showing circadian phase is encoded post-transcriptionally.

Impaired clock gene expression and abnormal diurnal regulation of hippocampal inhibitory transmission and spatial memory in a mouse model of Alzheimers disease

This study shows that AD mouse models have impaired clock gene expression and disrupted diurnal regulation of hippocampal inhibitory transmission and spatial memory.

Type 1 dopamine receptor (D1R)-independent circadian food anticipatory activity in mice

This study investigates the role of D1R signaling in food anticipatory activity (FAA) in mice, finding that while D1R promotes FAA, other dopamine receptors also contribute.

Post-Transcriptional Circadian Regulation in Macrophages Organizes Temporally Distinct Immunometabolic States

The paper shows that circadian regulation in macrophages involves extensive post-transcriptional control of the proteome, influencing metabolic states and immune functions.

Oscillating and stable genome topologies underlie hepatic physiological rhythms during the circadian cycle

The paper investigates circadian rhythms in liver chromatin organization and transcription, finding both clock-controlled and clock-independent chromatin structures regulate physiological functions.

Phase Gradients and Anisotropy of the Suprachiasmatic Network

The paper examines the suprachiasmatic nucleus (SCN) to identify intermediate structures called phaseomes through phase differences and connectivity gradients, revealing anisotropy in network organization.

Moonstruck sleep: Synchronization of Human Sleep with the Moon Cycle under Natural Conditions

This study shows that human sleep timing synchronizes with the lunar cycle under natural conditions, with sleep onset delayed and duration shortened before the full moon.