Circadian rhythm and melatonin

The brain clock portal system: SCN-OVLT

The paper describes a new portal system connecting the suprachiasmatic nucleus (SCN) and organum vasculosum of the lamina terminalis (OVLT) in the brain, suggesting new routes for secreted signals and redefining brain communication pathways.

Integration of brief light flashes varying in intensity and duration by the human circadian system

This study investigates how varying light intensity and duration affect the human circadian system using full-field flashes and measures circadian phase shifts and melatonin suppression.

A transcriptomic taxonomy of Drosophila circadian neurons around the clock

The paper characterizes Drosophila circadian neurons using single-cell RNA sequencing, identifying 17 cell categories with time-dependent gene expression patterns.

TMT-Opsins differentially modulate medaka brain function in a context-dependent fashion

This paper investigates how TMT-opsins modulate medaka brain function differently in various contexts, revealing non-additive interactions and behavioral impacts.

The risks of using the chi-square periodogram to estimate the period of biological rhythms

This study shows the chi-square periodogram (CSP) underestimates biological rhythm periods, especially in short time-courses, and recommends using alternative methods like the Lomb-Scargle periodogram.

Genome-wide screening of circadian and non-circadian impact of Neat1 genetic deletion

The paper identifies mRNAs regulated by Neat1 deletion in rat pituitary cells, revealing both circadian and non-circadian effects and their association with key biological processes.

Machine Learning to Summarize and Provide Context for Sleep and Eating Schedules.

This study uses machine learning to analyze sleep and eating schedules from 500 participants, proposing a framework to classify chronotypes and assess circadian misalignment for health guidance.

Global cognitive performance is not influenced by diurnal rhythm

The paper investigates whether diurnal rhythm affects cognitive performance in healthy adults and finds no significant effect of testing time on cognitive test results.

Evidence that pain sensitivity is rhythmic in humans, mainly driven by the endogenous circadian system and little by sleep

The paper shows that human pain sensitivity follows a circadian rhythm, primarily driven by the endogenous circadian system rather than sleep.

A Genome-wide microRNA screen identifies the microRNA-183/96/182 cluster as a modulator of circadian rhythms

This study identifies miR-183/96/182 as a circadian modulator through a genome-wide miRNA screen and validates its function in vitro and in vivo.

Multiple random phosphorylations in clock proteins provide long delays and switches

The paper models how multiple random phosphorylations in clock proteins generate delays and switches necessary for circadian oscillations.

Genome-wide correlation analysis reveals Rorc as potential amplitude regulator of circadian transcriptome output

The paper identifies Rorc as a key regulator of circadian transcriptome amplitude variation across mouse tissues by analyzing publicly available circadian transcriptome datasets.

Selective human tau protein expression in different clock circuits of the Drosophila brain disrupts different aspects of sleep and circadian rhythms

This paper expresses human tau proteins in specific Drosophila clock circuits and shows how it disrupts sleep and circadian rhythms in different ways.

Nonsense mediated decay and a novel protein Period-2 regulate casein kinase I in an opposing manner to control circadian period in Neurospora crassa

This study identifies Period-2 and Nonsense Mediated Decay as regulators of CKI levels, affecting circadian period in Neurospora crassa.

Global Age-Specific Patterns of Cyclic Gene Expression Revealed by Tunicate Transcriptome Atlas

The paper identifies age-specific circadian gene expression patterns in Botryllus schlosseri and links them to aging phenotypes and pathways.

High frequency neuronal bursting is essential for circadian and sleep behaviors in Drosophila

The paper identifies the hyperpolarization-activated cation current Ih as essential for circadian and sleep behaviors in Drosophila by enabling high-frequency neuronal bursting in lateral ventral neurons.

CK2 inhibits TIMELESS nuclear export and modulates CLOCK transcriptional activity to regulate circadian rhythms

The paper identifies TIM phosphorylation sites in Drosophila and shows that CK2-dependent phosphorylation of TIM(S1404) regulates nuclear export and circadian rhythms, with implications for human FASPS.

Characterization of mWake expression in the murine brain

The paper characterizes mWake expression in the adult mouse brain, identifying its presence in neurons and non-neuronal cells across multiple brain regions and providing single-cell RNA sequencing analysis of hypothalamic mWake+ cells.

The CBP KIX domain regulates long-term memory and circadian activity

This study shows that the CBP KIX domain is essential for long-term memory and circadian rhythms by regulating CREB and CLOCK target genes.

Regulation of olfactory associative memory by the circadian clock output signal Pigment-dispersing factor (PDF)

This study shows that Pigment-dispersing factor (PDF) signaling is essential for olfactory associative memory in Drosophila, with distinct effects on appetitive and aversive memory based on circadian timing.

The projections of ipRGCs and conventional RGCs to retinorecipient brain nuclei

This study shows conventional RGCs innervate ipRGC-recipient nuclei beyond the suprachiasmatic nucleus, revealing distinct stratification patterns and innervation differences.

Mice hypomorphic for Pitx3 define a minimal dopamine neuron population sufficient for entraining behavior and metabolism to scheduled feeding

The paper confirms that Pitx3ak mice do not entrain behavioral and metabolic rhythms to light-dark cycles but can entrain to feeding schedules, suggesting a minimal dopamine neuron population is sufficient for food entrainment.

Automated Feature Extraction from Population Wearable Device Data Identified Novel Loci Associated with Sleep and Circadian Rhythms

The paper develops unsupervised methods to extract sleep and circadian features from wearable data, identifies 53 novel genetic loci associated with sleep, circadian rhythms, and related traits.

The circadian hippocampus and its reprogramming in epilepsy: impact for chronotherapeutics

The paper identifies daily oscillating transcripts in the hippocampus of control and epileptic mice, showing distinct circadian patterns and implications for drug timing.

Cold induced chromatin compaction and nuclear retention of clock mRNAs resets the circadian rhythm

The paper shows that cold exposure causes chromatin compaction and nuclear retention of circadian clock transcripts, which resets the circadian rhythm upon rewarming.

Leptin-receptor neurons in the dorsomedial hypothalamus regulate the timing of circadian rhythms in feeding and metabolism in mice

This study identifies DMH leptin receptor-expressing neurons as critical for regulating circadian rhythms in feeding and metabolism in mice.

Early detection of daylengths with a feedforward circuit coregulated by circadian and diurnal cycles

The paper develops a mathematical model to explain how eS6 phosphorylation integrates circadian and diel signals to detect daylength changes.

MOSAIC: A Joint Modeling Methodology for Combined Circadian and Non-Circadian Analysis of Multi-Omics Data

MOSAIC improves circadian rhythm detection in proteomic data by integrating transcriptomic information, outperforming existing methods and revealing non-circadian trends.

Sexually dimorphic influence of the circadian clock gene Bmal1 in the striatum on alcohol intake

This study shows that Bmal1 deletion in striatal neurons affects alcohol intake differently in male and female mice, with males showing increased intake and females decreased intake.

Mathematical Analysis of Robustness of Oscillations in Models of the Mammalian Circadian Clock

The paper analyzes the robustness of oscillations in a circadian clock model by modifying parameter constraints and feedback loops to achieve realistic biological parameters.