Reproductive Biology and Fertility

Pre-implantation mouse embryo movement under hormonally altered conditions

This study examines how altered hormonal environments affect pre-implantation mouse embryo movement in different diapause models, finding that both estrogen and progesterone influence embryo movement patterns.

The central role of pyruvate metabolism on the epigenetic and molecular maturation of bovine cumulus-oocytes complexes.

This study examines how pyruvate metabolism affects histone acetylation and gene expression in bovine oocytes during in vitro maturation.

CHK1-CDC25A-CDK1 regulate cell cycle progression in early mouse embryos to protect genome integrity

This study identifies CHK1's role in regulating cell cycle progression in early mouse embryos to maintain genome integrity and prevent aneuploidy.

OVGP1 is an oviductal fluid factor essential particularly for early embryonic development in golden hamsters

This study shows that OVGP1, an oviductal humoral factor, is essential for female fertility and early embryonic development in golden hamsters.

Pregranulosa cells engage a distinct transcriptional programme prior to cell-cycle dependent primordial follicle activation

The paper identifies a distinct transcriptional programme in pregranulosa cells before primordial follicle activation using single-cell RNA sequencing in mice.

Alternative culture systems for bovine oocyte in vitro maturation: liquid marbles and differentially shaped 96-well plates

This study evaluates two alternative culture systems for bovine oocyte in vitro maturation, finding no significant differences in meiotic resumption or embryo development compared to conventional 2D systems.

Maternal age, obesity and hyperglycaemia are associated with a delay in preimplantation development in a mouse model of type 2 diabetes

This study shows that maternal age and high fat diet reduce preimplantation embryo development in mice, with older age having a greater impact than diet.

Perivascular cells support folliculogenesis in the developing ovary

The paper identifies Nestin+ perivascular cells in mice as multipotent progenitors contributing to ovarian lineages and shows their role in folliculogenesis through Notch signaling.

Integration of mouse ovary morphogenesis with developmental dynamics of the oviduct, ovarian ligaments, and rete ovarii.

This study investigates the structural relationships between the ovary and surrounding tissues during mouse development, identifying key interactions that drive ovary morphogenesis.

Establishment of porcine ovarian follicles treated with t-BHP for an in vitro aging model

This study uses t-BHP to induce ovarian follicle senescence in pigs, showing increased ROS, Caspase-3, P53, Foxo1, and decreased SOD, establishing an in vitro aging model.

Murine blastocysts generated by in vitro fertilization show increased Warburg metabolism and altered lactate production

This study shows that IVF-generated murine blastocysts exhibit increased Warburg metabolism and altered lactate production compared to naturally conceived embryos.

A single cell atlas of the cycling murine ovary

This study constructs a single-cell atlas of the murine ovary by analyzing >34,000 cells across the estrous cycle to characterize cell state dynamics and transcriptional changes.

Metabolic enhancement of mammalian developmental pausing

The paper identifies lipid metabolism as a key factor in developmental pausing, showing that enhancing fatty acid oxidation extends embryo survival during mTOR inhibition.

Translation control by maternal Nanog promotes oocyte maturation and early embryonic development

This study shows maternal Nanog controls oocyte maturation and early embryonic development by repressing eef1a1l2 transcription, which reduces translational activity and prevents ER stress.

Germ-cell specific eIF4E1B regulates maternal RNA translation to ensure zygotic genome activation

The paper shows that eIF4E1B regulates maternal mRNA translation to enable zygotic genome activation by protecting chromatin remodeling and reprogramming factor mRNAs from degradation.

Targeted deletion of uterine glandular Foxa2 induces embryonic diapause in mice

This study shows that uterine deletion of Foxa2 in mice leads to embryonic diapause, with persistent Msx1 expression and altered estrogenic effects on uterine quiescence.

Evidence for intercellular bridges and radial patterning of meiotic initiation in the human fetal ovary

This study uses 3D analysis to show radial meiotic initiation and intercellular bridges in human fetal ovaries, with variation in meiotic cell numbers and asynchronous transitions between mitotic and meiotic stages.

Transcriptome analysis of human preimplantation embryo reveals expressed waves associated with blastulation failure based on embryonic grade and age

The paper analyzes transcriptomes of arrested human embryos to identify molecular markers associated with blastulation failure and developmental stages.

Mouse oocytes develop in cysts with the help of nurse cells

The paper identifies nurse cells in mouse oocyte cysts that support oocyte development through cytoplasmic transfer and conserved mechanisms across species.

A standardized approach for case selection and genomic data analysis of maternal exomes for the diagnosis of oocyte maturation and early embryonic developmental arrest in IVF

The paper develops a methodology for selecting IVF cases with oocyte maturation defects and preimplantation embryo lethality, using whole-exome sequencing and bioinformatics to identify causative genetic variants.

Production of Offspring from Azoospermic Mice with Meiotic Failure: Precise Biparental Meiosis within Halved Oocytes

This study shows that reducing ooplasmic volume in oocytes improves meiotic accuracy and embryo development, enabling offspring production from azoospermic mice with spermatocyte arrest.

The regulatory landscapes of human ovarian ageing

This study uses single-nuclei multi-omics analysis to identify molecular and cellular changes in human ovarian ageing and links genetic variants to age at natural menopause.

Machine Learning Reveals The Effect of Maternal Age on The Mouse Pre-Implantation Embryo Developmental Timing

The paper uses machine learning to analyze embryo developmental timing and shows that maternally aged embryos lose temporal regulation, impacting viability.

The Requirement of Ubiquitin C-Terminal Hydrolase L1 (UCHL1) in Mouse Ovarian Development and Fertility

This study shows UCHL1 is essential for ovarian folliculogenesis, estrous cyclicity, and fertility in female mice.

Lhx9 haploinsufficiency alters transcription in the adult mouse ovary, causing subfertility and abnormal epithelium

Lhx9 haploinsufficient mice show subfertility, altered steroid gene expression, and abnormal ovarian surface epithelium.

The PAF1 complex cell-autonomously promotes oogenesis in Caenorhabditis elegans

This study shows that the PAF1 complex is required for oogenesis in C. elegans by promoting oocyte maturation gene expression.

Persistent pervasive transcription in RNA exosome depleted oocytes results in loss of female fertility

This study shows that depletion of Dis3 in oocytes leads to persistent transcription and fertility loss due to disrupted RNA processing and epigenetic changes.

The addition of antibiotics to embryo culture media caused altered expression of genes in pathways governing DNA integrity in mouse blastocysts

This study shows that adding antibiotics to mouse embryo culture media alters gene expression related to DNA integrity, potentially compromising genomic stability.

Temporal and spatial dynamics mapping reveals follicle development regulated by different stromal cell populations

The paper maps temporal and spatial dynamics of follicle development in mice by analyzing single-cell and spatial transcriptomes, revealing distinct stromal cell populations with specific roles in follicle development.

HIF1A modulate glycolysis function to governs mouse ovarian microenvironment metabolic plasticity in aging single cell resolution

This study uses single-cell RNA-seq to analyze age-related changes in mouse ovarian microenvironment metabolism, identifying HIF1A's role in modulating glycolysis and other metabolic pathways.