Renal cell carcinoma treatment

Bisantrene potentiates tyrosine kinase inhibitor activity in clear cell renal cell carcinoma

This study shows bisantrene enhances the effectiveness of tyrosine kinase inhibitors in ccRCC by sustaining AKT inhibition and overcoming TKI resistance.

Dual Inhibition of CDK4/6 and mTORC1 Establishes a Preclinical Strategy for Translocation Renal Cell Carcinoma

This study identifies CDK4/6 and mTORC1 pathway activation in tRCC and shows that their dual inhibition synergistically suppresses tRCC cell growth in vitro and xenografts in vivo.

Spatial analysis reveals a novel inflammatory tumor transition state which promotes a macrophage-driven induction of sarcomatoid renal cell carcinoma

The paper identifies a transcriptional transition state in ccRCC cells that drives sarcomatoid transformation and enhances immunotherapy response via macrophage and T-cell interactions.

A systems-level machine learning approach uncovers therapeutic targets in clear cell renal cell carcinoma

This paper develops a machine learning framework for therapeutic target discovery in ccRCC, identifying 16 targets and novel mechanisms with superior efficacy to standard-of-care drugs.

Angiogenic and Immune Predictors of Neoadjuvant Axitinib Response in Renal Cell Carcinoma with Venous Tumour Thrombus

The paper assesses neoadjuvant axitinib response in RCC with VTT using multiparametric analysis and identifies angiogenic and immune predictors of treatment response.

Machine Learning-Enhanced Extraction of Protein Signatures of Renal Cell Carcinoma from Proteomics Data

The paper uses proteomics data and machine learning to identify protein signatures distinguishing renal cell carcinomas from normal tissues and different subtypes.

Deep visual multi-omics profiling reveals mechanisms that underlie cancer cell differentiation and aggressiveness in clear cell renal cell carcinoma

This study uses AI-based image analysis and multi-omics profiling to link morphological features with molecular changes in ccRCC, identifying unique molecular profiles in aggressive rhabdoid tumors.

Identification of a novel papillary renal cell carcinoma molecular subtype characterized by HIF-pathway over-activation

This paper identifies a novel molecular subtype of papillary renal cell carcinoma (pRCC) characterized by HIF-pathway overactivation, associated with poor prognosis and distinct biological features.

DNA methylation subtypes inferred from transcriptomes guide sunitinib and immunotherapy selection in renal cancer

The paper identifies DNA methylation subtypes from transcriptomes to guide sunitinib and immunotherapy selection in renal cancer, finding hyper-methylated tumors respond better to atezolizumab plus bevacizumab.

Fibroblast Activation Protein Defines an Aggressive, Immunosuppressive EMT-associated Tumor Subtype in Highly Inflamed Localized Clear Cell Renal Cell Carcinoma

The paper identifies FAP-expressing EMT-associated cancer cells in highly inflamed localized ccRCC as an aggressive, immunosuppressive subtype linked to poor prognosis and metastasis.

Long-read Spatial Transcriptomic Profiling of Patient-derived ccRCC Tumoroids Reveals Heterogeneity in Isoform and Gene Expression

The paper uses long-read spatial transcriptomics on ccRCC tumoroids to reveal gene and isoform expression heterogeneity, identifying distinct functional tumor clusters and isoform-specific patterns.

Characterization of alternative mRNA splicing associated with tumor thrombus in clear-cell renal cell carcinoma

The paper analyzes RNAseq data to identify alternative splicing patterns associated with tumor thrombus formation in clear-cell renal cell carcinoma.

Epigenomic signatures as circulating and predictive biomarkers in sarcomatoid renal cell carcinoma

The paper identifies epigenomic signatures in sarcomatoid renal cell carcinoma (sRCC) that predict response to immune checkpoint inhibitors and are detectable in plasma, enabling non-invasive diagnosis.

Integrative Analysis of Germline Rare Variants in Clear and Non-Clear Cell Renal Cell Carcinoma

This study identifies germline rare variants associated with clear and non-clear cell RCC, accounting for population stratification, and finds distinct risk patterns and somatic associations.

Identification Cure Hub Genes of Chromophobe Cell Renal Carcinoma : A study based on Weighted Gene Co-expression Network Analysis (WGCNA) and the Cure Defective Models

This study identifies hub genes associated with cure in chromophobe cell renal carcinoma using WGCNA and the defective Gompertz model, finding ten genes with strong predictive value.

CHPF boosts proliferation and invasion of clear cell renal cell carcinoma

This study investigates the role of CHPF in ccRCC, finding it promotes proliferation and invasion, suggesting it as a prognostic marker and therapeutic target.

Comprehensive Analysis of the Expression and Prognosis for PSMBs in Clear Cell Renal Cell Carcinoma

This study evaluates the expression and prognostic significance of PSMBs in clear cell renal cell carcinoma, identifying PSMB4 and PSMB10 as potential therapeutic targets and biomarkers.

Cellular And Molecular Effects Of Understudied Kinase Pregnancy Upregulated Non-Ubiquitous Calcium-Calmodulin Dependent Kinase (PNCK) In Renal Cell Carcinoma.

This study identifies PNCK as a differentially overexpressed kinase in RCC, showing its role in cell proliferation, apoptosis, and disease progression, suggesting it as a potential drug target.

Establishment of a Prognostic Prediction and Drug Selection Model for Patients with Clear Cell Renal Cell Carcinoma by Multi-Omics Data Analysis

The paper develops a prognostic model and drug selection framework for clear cell renal cell carcinoma using multi-omics data from TCGA, identifying high- and low-risk patient subtypes with significant survival differences.

Multi-regional characterisation of renal cell carcinoma and microenvironment at single cell resolution

A multi-regional single-cell study of kidney tumours reveals clonotypic heterogeneity, immune cell exhaustion, and potential therapeutic targets through transcriptomic and exomic analysis.

Screening and identification of key biomarkers in clear cell renal cell carcinoma based on bioinformatics analysis

This study identifies 10 hub genes associated with ccRCC tumorigenesis and prognosis through bioinformatics analysis of gene expression data.

Patient stratification of clear cell renal cell carcinoma using the global transcription factor activity landscape derived from RNA-seq data

This study stratifies clear cell renal cell carcinoma patients using transcription factor activity derived from RNA-seq data to predict prognosis and identify subtypes with distinct biomarkers and pathways.

Classification of clear cell renal cell carcinoma based on PKM alternative splicing

The paper identifies two ccRCC subtypes based on PKM alternative splicing and proposes drug repurposing for each subtype.