Neurogenesis and neuroplasticity mechanisms

This study shows that human spinal cord differentiation in vitro is faster than in vivo and stalls when grafted into a different species, highlighting the role of extrinsic signals.

This study uses single-cell RNA sequencing to reveal transcriptional heterogeneity in ventricular zone cells of the embryonic mouse forebrain, showing spatial and temporal gene expression differences.

This study identifies YME1L as a mitochondrial protease that regulates metabolic state transitions in adult neural stem cells, ensuring self-renewal and preventing premature differentiation.

The paper shows that miR-200a regulates mesodermal cell fate during spinal cord regeneration by repressing brachyury expression in axolotls.

The paper shows that clusters of Neurofascin A on axons predict node of Ranvier positions before myelination, independent of myelin sheath growth.

This study uses iterative immunofluorescence imaging to analyze age-related changes in the dentate gyrus niche, identifying reorganization and microenvironmental changes affecting neurogenesis in mice.

This study uses cerebral organoids to show that TSC2 mutations cause over-proliferation of caudal late interneuron progenitors, leading to Tuberous Sclerosis Complex.

The paper isolates side populations from adult neurogenic niches and identifies them as endothelial cells rather than neural stem cells.

This study identifies a subpopulation of astrocyte progenitors in the neonatal brain regulated by Sonic hedgehog signaling, contributing to cortical astrocyte development.

This study shows that WDR81 loss of function disrupts endosomal trafficking of EGFR, reduces MAP kinase activation, and causes microcephaly by impairing radial glial progenitor proliferation.

The paper shows that the embryonic brain and scalp tissues mechanically interact, with the scalp recoiling to confine and fold the brain during development.

This study investigates interneuron migration defects in Timothy syndrome using human forebrain assembloids and identifies pharmacological targets to rescue migration abnormalities.

The paper shows that modulating the Sonic Hedgehog pathway in trisomic NPCs rescues gene expression dysregulation associated with Down syndrome.

This study identifies Klf9 as a transcriptional regulator that suppresses symmetric self-renewal of radial-glial neural stem cells in the adult hippocampus.

The paper shows that vision selectively drives the specification of upper-layer glutamatergic cell types in the mouse visual cortex through gene expression regulation.

The paper shows that EAAT1 facilitates glutamate-induced self-renewal of adult hippocampal NSCs through lipogenesis, highlighting a non-canonical mechanism of niche sensing.

This study uses single-cell RNA-Seq to analyze early chick hypothalamic development, revealing that hypothalamic cells originate from prethalamic-like progenitors and identifying novel molecular regulators.

This study shows that including vascular cells with neural precursor cells improves graft survival and vascularization after stroke.

The paper identifies a transcription factor network and enhancers involved in cortical regional patterning using mouse embryonic data.

This study shows that AP2gamma deficiency in mice reduces hippocampal neurogenesis and causes lasting behavioral deficits from juvenile to adult stages.

The paper uses single-cell RNA sequencing to study how transcriptional changes during neurogenesis lead to the sequential generation of distinct septal neuron types.

The paper develops a protocol to generate human cerebellar granule cells from pluripotent stem cells and identifies molecular differences in their development compared to mice.

The paper identifies a temporal patterning program in vertebrate neurons controlled by transcription factors and the TGFβ pathway, showing its role in generating neuronal diversity.

The paper examines how the birthdate of CA1 pyramidal neurons correlates with their diversity in the ventral hippocampus, showing that early-born neurons have distinct features.

The paper analyzes transcriptomic changes in Gli1-deficient neural stem cells during demyelination to identify mechanisms enhancing remyelination.

This study identifies BMP/Id1 signaling as critical for maintaining NSC quiescence and regenerative capacity in adult zebrafish telencephalon, with Her4.1 as a key downstream target.

The paper investigates the role of Lis1 in generating basal radial glia-like cells in the mouse, showing that Lis1 depletion prevents their formation and disrupts brain development.

The paper uses single-cell RNA-sequencing to identify dynamic molecular signatures during cortical arealization in the human brain, revealing gene expression patterns that define distinct cortical areas.

The paper identifies Foxf2 and Olig2 as key transcription factors regulating striatal compartmentation and neuronal differentiation through RNA- and ATAC-seq analysis of murine striosomes and matrix.