Extracellular vesicles in disease

Circulating Small Extracellular Vesicle RNA Profiling for the Detection of T1a stage Colorectal Cancer and Precancerous Advanced Adenoma

This study identifies sEV-RNAs that distinguish T1a stage colorectal cancer and advanced adenoma from normal controls using liquid biopsy.

Therapeutic potential of red blood cell-derived extracellular vesicles in reducing neuroinflammation and protecting against retinal degeneration.

Pseudomonas aeruginosa infection increases palmitoyl carnitine release by host-derived extracellular vesicles

This study identifies palmitoyl carnitine (PAMC) as a metabolite upregulated in host-derived extracellular vesicles during Pseudomonas aeruginosa infection, which modulates immune responses and bacterial growth.

Comprehensive Phenotyping of Extracellular Vesicles in Blood of Healthy Humans - Insights into Cellular Origin and Biological Variability

The paper quantifies circulating extracellular vesicles (EVs) in healthy humans, showing high inter-individual variability and identifying platelets as the main source of tetraspanin+ EVs.

Depletion-assisted multiplexed cell-free RNA sequencing reveals distinct human and microbial signatures in plasma versus extracellular vesicles

The paper develops DETECTOR-seq to analyze fragmented cell-free RNAs in plasma and extracellular vesicles, revealing distinct RNA distributions and potential biomarkers for cancer detection.

Emerging role of mesenchymal stem cell-derived extracellular vesicles to ameliorate hippocampal NLRP3 inflammation induced by binge-like ethanol treatment in adolescence

This study shows that mesenchymal stem cell-derived extracellular vesicles reduce hippocampal NLRP3 inflammasome activation and inflammation in adolescent mice after binge ethanol treatment.

Lipogenic Lung Fibroblast-derived Extracellular Vesicles Mitigate Cigarette Smoke-Induced Chronic Obstructive Pulmonary Disease Pathologies through LAT1-mediated Alveolar Type II Cell Restoration

This study shows that lipogenic lung fibroblast-derived extracellular vesicles reduce COPD pathologies by restoring alveolar type II cells via LAT1-mediated mechanisms.

Prostate Cancer Reshapes the Secreted and Extracellular Vesicle Urinary Proteomes

The paper quantifies secreted and extracellular vesicle (EV) urinary proteomes in men with and without prostate cancer, showing their stability and utility in distinguishing malignant from benign lesions.

Assessment of brain-derived extracellular vesicle enrichment for blood biomarker analysis in age-related neurodegenerative diseases: An international overview

The paper assesses BEV-enrichment protocols for blood biomarkers in neurodegenerative diseases and identifies CNS-specific proteins for enrichment and biomarker use.

Proteomic Profiling of Mesenchymal Stem Cell-Derived Extracellular Vesicles: Impact of Isolation Methods on Protein Cargo

This study compares protein cargo differences in mesenchymal stem cell-derived extracellular vesicles isolated by three methods, finding method-specific impacts on proteome composition and biological function.

Auto-loaded TRAIL-exosomes derived from induced neural stem cells for brain cancer therapy

The paper demonstrates that TRAIL-loaded exosomes from induced neural stem cells effectively target and kill brain cancer cells in vitro and in vivo.

EV-Checklist: A fast documentation tool for enhancing transparency and accessibility in extracellular vesicle research.

EV-Checklist is a digital tool that streamlines documentation for extracellular vesicle research, improving transparency and accessibility by generating a concise PDF table for manuscripts.

Proteomic analysis to classify extracellular vesicles and plasmodesmata in Arabidopsis cell culture supernatants

The paper identifies and distinguishes extracellular vesicle and plasmodesmata proteins in Arabidopsis cell culture supernatants using proteomic and imaging analyses.

SLAMseq reveals transfer of RNA from liver to kidney in the mouse

The paper uses SLAMseq to detect RNA transfer from liver to kidney in mice, finding increased transfer after liver injury.

Unveiling the Secrets of Extracellular Vesicles in Urban Water Systems: Understanding the Link Between Human and Environmental Health

This study investigates extracellular vesicles in urban water systems to link human activities with microbial community impacts on public health and river biodiversity.

Full-length tRNAs lacking a functional CCA tail are selectively sorted into the lumen of extracellular vesicles

The paper identifies that full-length tRNAs with truncated CCA tails are selectively sorted into extracellular vesicles, suggesting a new mechanism for EV cargo selection.

The DNA-repair protein APE1 participates with hnRNPA2B1 to motif-enriched and prognostic miRNA secretion

The paper identifies APE1-dependent miRNAs secreted via exosomes, showing their prognostic significance in cancer and their regulation by APE1 and hnRNPA2B1.

iPSC-derived healthy human astrocytes selectively load miRNAs targeting neuronal genes into extracellular vesicles

The paper identifies miRNAs selectively loaded into extracellular vesicles from healthy human astrocytes and links them to neurodevelopmental disorders.

Altered Expression of microRNAs Implicated in Hematopoietic Dysfunction in the Extracellular Vesicles of Bone Marrow-Mesenchymal Stromal Cells in Aplastic Anemia

The paper identifies differentially expressed miRNAs in EVs from AA BM-MSC and links them to altered HSPC gene expression and pathways involved in cell cycle and hematopoiesis.

Novel multiparametric bulk and single extracellular vesicle pipeline for adipose cell-specific biomarker discovery in paired human biospecimens

The paper develops a multiparametric pipeline to isolate and characterize adipose-derived extracellular vesicles from human biospecimens, identifying cell-specific biomarkers and pathways associated with obesity.

Proteome of human glioblastoma and meningioma tissue small extracellular vesicles

This study isolates and characterizes small extracellular vesicles directly from human brain tumor tissue, identifying novel proteins and pathways associated with these vesicles.

A New Large-Scale Extracellular Vesicle Production Strategy for Biomedical Drug Development

This paper introduces a novel large-scale EV production strategy with upstream fed-batch suspension cell culture and downstream chromatographic purification for clinical applications.

Extracellular vesicles isolated from frozen and fresh human melanoma tissue are similar in purity and protein composition

Identification of markers for the isolation of neuron-specific extracellular vesicles

The paper identifies NRXN3 as a neuron-specific marker for isolating extracellular vesicles from biofluids and develops methods to isolate these vesicles for neurological disease research.

Neonatal enteroids absorb extracellular vesicles from human milk-fed infant digestive fluid

This study isolates extracellular vesicles from human milk and neonatal digestive fluid and shows they are taken up by intestinal epithelial cells.

Benchmarking transcriptional deconvolution methods for estimating tissue- and cell type-specific extracellular vesicle abundances

The paper benchmarks deconvolution methods to estimate tissue- and cell type-specific extracellular vesicle abundances in biological fluids and identifies accurate methods.

Differentiation of Large Extracellular Vesicles in Oral Fluid: Combined Protocol of Small Force Centrifugation and Pattern Analysis

The paper develops a protocol to subclassify large extracellular vesicles in oral fluid based on physicochemical properties using sedimentation patterns and clustering analysis.

Arc mediates intercellular synaptic plasticity via IRSp53-dependent extracellular vesicle biogenesis

This study shows Arc EVs mediate intercellular synaptic plasticity through IRSp53-dependent biogenesis, leading to loss of surface AMPA receptors in neighboring dendrites.

Proteome and phospholipidome interrelationship of synovial fluid-derived extracellular vesicles in equine osteoarthritis: An exploratory multi-omics study to identify composite biomarkers

Small non-coding RNA content in plasma-derived extracellular vesicles distinguish ataxic SCA3 mutation carriers from pre-ataxic and control subjects