Extracellular vesicles in disease

Dopey-dependent regulation of extracellular vesicles maintains neuronal morphology

The paper identifies a network involving DIP-2, SAX-2, PAD-1, and TAT-5 that regulates neuronal morphology by controlling extracellular vesicle release in C. elegans.

Unveiling the role of miRNAs from MSC-EVs in neuroinflammation and behavioral impairments induced by chronic alcohol consumption

This study investigates the effects of MSC-EVs on neuroinflammation and behavioral impairments caused by chronic alcohol consumption in mice, finding that MSC-EVs reduce inflammation and improve cognitive and addictive-like behaviors.

Rapid Assessment of Biomarkers on Single Extracellular Vesicles Using 'Catch and Display' on Ultrathin Nanoporous Silicon Nitride Membranes

This paper introduces CAD-LB, a microfluidic technique for rapid EV biomarker assessment, validated on nanoparticles, purified EVs, and clinical plasma samples.

Brain-derived exosomal hemoglobin transfer contributes to neuronal mitochondrial homeostasis under hypoxia

This study identifies exosomal hemoglobin transfer from non-neuronal cells to neurons under hypoxia as a mechanism to maintain mitochondrial homeostasis and protect against neurological injury.

Small RNAs in plasma extracellular vesicles define biomarkers of premanifest changes in Huntington's disease

The paper identifies small RNAs in plasma extracellular vesicles as biomarkers for premanifest changes in Huntington's disease, showing their association with cognitive performance and longitudinal progression.

Snorkel-tag Based Affinity Chromatography for Recombinant Extracellular Vesicle Purification

This paper introduces a Snorkel-tag system for affinity purification of extracellular vesicles using CD81 fused with tags and transmembrane domains, enabling non-destructive isolation and future applications in tracing and analyzing EVs.

Inflammatory pain resolution by mouse serum-derived small extracellular vesicles

This study shows that mouse serum-derived small extracellular vesicles can reduce inflammatory pain through opioid signaling and immunomodulation.

Simultaneous protein and RNA analysis in single extracellular vesicles, including viruses: SPIRFISH

SPIRFISH detects protein and RNA in single nanoparticles, revealing variability in structure and RNA packaging efficiency.

Droplet Sequencing Reveals Virulence Gene Clusters in Oral Biofilm Extracellular Vesicles

This paper introduces a microdroplet-based sequencing technique to analyze DNA content in individual bacterial extracellular vesicles, revealing gene clusters related to virulence and horizontal gene transfer in oral biofilms.

Quantitative proteomics reveals differential extracellular vesicle cargo from M1 and M2 monocyte-derived human macrophages

The paper uses quantitative proteomics to compare EV cargo between M1 and M2 macrophages, identifying 132 differentially expressed proteins and their functional roles in immune responses.

The nuclear speckles protein SRRM2 is a new therapeutic target molecule on the surface of cancer cells

The paper identifies SRRM2 as a surface-exposed cancer target and shows its utility in CAR-T cell therapy.

Cholesterol Metabolite 27-Hydroxycholesterol Enhances the Secretion of Cancer Promoting Extracellular Vesicles by a Mitochondrial ROS-Induced Impairment of Lysosomal Function

This study shows that 27-hydroxycholesterol increases EV secretion by impairing lysosomal function through mitochondrial ROS, and antioxidant treatment reverses this effect.

Glutamatergic regulation of miRNA-containing exosome precursor trafficking and secretion from cortical neurons

This study investigates how glutamatergic signaling affects exosome precursor trafficking and secretion in cortical neurons, showing increased exosome release but minimal changes in miRNA content.

Mechanical force of uterine occupation enables large vesicle extrusion from proteostressed maternal neurons

The paper shows that mechanical uterine distention enhances exopher extrusion from proteostressed C. elegans neurons, linking mechanical force to extracellular vesicle production and neurodegenerative disease mechanisms.

Mesenchymal stem cell-derived extracellular vesicles alleviate imiquimod-induced psoriasis symptoms in a mouse disease model

This study shows that mesenchymal stem cell-derived extracellular vesicles reduce psoriasis symptoms in a mouse model induced by imiquimod.

Identification of novel myokines and putative protein targets that mediate functional adaptations in response to chronic contractile activity induced skeletal muscle-extracellular vesicle treatment

The paper identifies novel proteins and pathways in skeletal muscle-derived extracellular vesicles following chronic contractile activity, suggesting their role in metabolic and anti-tumorigenic effects.

Endocytic BDNF secretion through extracellular vesicle-dependent secretory pathways in astrocytes

This study identifies an extracellular vesicle-dependent secretory pathway in astrocytes for resecretion of endocytosed BDNF, mediated by Vamp3-associated signaling.

Three-step scalable production of extracellular vesicles from pancreatic beta cells in stirred tank bioreactors promotes cell maturation and release of ectosomes with preserved immunomodulatory properties

This paper develops a three-step bioprocess using stirred tank bioreactors to produce extracellular vesicles from pancreatic beta cells, enhancing their maturation and immunomodulatory properties.

Unravelling the impact of TLR4 and sex on chronic alcohol consumption-induced lipidome dysregulation in extracellular vesicles

This study investigates how TLR4 and sex affect lipidome changes in EVs from chronically alcohol-exposed mice, identifying lipid subclasses linked to inflammation and EV biogenesis.

Mechanical stress and caveolin-1 control the release of extracellular vesicles with increased tumorigenic properties

This study shows mechanical stress increases EV release from cancer cells via caveolin-1, leading to more tumorigenic EVs that promote metastasis.

Dynamics of MicroRNA Secreted via Extracellular Vesicles During the Maturation of Embryonic Stem Cell-Derived Retinal Pigment Epithelium

This study profiles miRNA in extracellular vesicles secreted during the maturation of human embryonic stem cell-derived RPE cells to inform EV-based therapeutics.

Extracellular Vesicle-Mediated Delivery of HIF1a Reprograms Macrophages for resolutive response in Sepsis

This study delivers HIF1 via extracellular vesicles to reprogram hepatic macrophages, promoting pro-efferocytic and pro-survival macrophage subsets to enhance sepsis resolution.

The pro-apoptotic effect of chronic contractile activity-induced extracellular vesicles on Lewis Lung Carcinoma cells

This study shows that chronic contractile activity-induced skeletal muscle-derived extracellular vesicles reduce LLC cell viability and induce apoptosis and senescence.

The Hemopurifier removes extracellular vesicles and microRNAs from renal perfusates following controlled oxygenated rewarming of discarded donor kidneys

The paper demonstrates that the Hemopurifier reduces extracellular vesicles, dsDNA, and microRNAs in perfusates from discarded donor kidneys, suggesting potential benefits for kidney transplantation.

The Rubicon-WIPI axis regulates exosome biogenesis during aging

This study identifies the Rubicon-WIPI axis as a regulator of exosome biogenesis, showing its role in age-dependent exosome release and microRNA fate in mice.

Extracellular vesicle-mediated secretion of chlorophyll biosynthetic intermediates in the cyanobacterium Leptolyngbya boryana

This study characterizes extracellular vesicles (EVs) from cyanobacteria, showing they contain chlorophyll intermediates and may help manage their accumulation.

Keratinocyte-derived exosomes in painful diabetic neuropathy

This study investigates keratinocyte-derived exosomes in a mouse model of painful diabetic neuropathy, finding differences in their molecular content and showing retrograde trafficking to DRG neurons.

Characterizing the role of exosomal miRNAs in metastasis

This study identifies exosomal miRNAs that influence the pre-metastatic niche across multiple cancers, showing their association with survival and chemotherapy response.

Immunojanus Particles for low-volume and isolation-free unlabeled characterization of small Extracellular Vesicle in biofluids: Characterization of disease type by surface marker profiling

This paper introduces Immunojanus Particles (IJPs) for rapid, isolation-free detection and characterization of small extracellular vesicles (sEVs) in biofluids, showing high accuracy in disease type identification.

Circulating extracellular vesicle microRNAs mediate immune modulation of social behavior in mice

The paper shows that EV miRNAs from WT mice improve sociability in immunodeficient mice by modulating synaptic function and immune-neuron communication.