Reproductive System and Pregnancy

An atlas of transcriptional dynamics in maternal blood over the course of healthy pregnancy

The paper presents a longitudinal transcriptomic atlas of maternal peripheral blood during healthy pregnancy, identifying 720 pregnancy-specific genes and nine transcriptional modules associated with immune and metabolic changes.

Preimplantation factor (PIF) is an endogenous inhibitor of potassium channel KV1.3 regulating neutrophil function during pregnancy

The paper identifies PIF as a placenta-derived peptide that inhibits KV1.3 channels in neutrophils, altering their function during pregnancy.

A cross-sectional examination of immune adaptations during pregnancy in the ECHO Cohort

This study examines how circulating inflammatory proteins change with gestational age in pregnancy and identifies associations with maternal and fetal characteristics.

Impact of vitamin D deficiency on defective endometrial decidualization and the repressive role of vitamin D receptor (VDR) in the epigenomic network

This study shows that vitamin D receptor (VDR) regulates endometrial decidualization by modulating chromatin accessibility and gene expression, with implications for fertility and uterine disorders.

Microbial-derived D-lactate and LPS shape growth and inflammatory signalling in endometrial glandular epithelium

This study investigates how microbial compounds D-lactate and LPS affect endometrial epithelial function using organoids, showing distinct gene expression changes related to growth and inflammation.

Single-cell Analysis of Paired FFPE Placentas Reveals Trophoblast Reprogramming and Immune Dysregulation in Chronic Villitis of Unknown Etiology

The paper develops an FFPE-compatible single-nucleus RNA sequencing strategy to analyze paired placentas from VUE pregnancies, revealing immune dysregulation and trophoblast reprogramming.

Implantation failure linked to altered uterine NK cells in PCOS-like mice

The paper shows that in a PCOS-like mouse model, altered uterine NK cells contribute to implantation failure through disrupted maturation and compensatory changes in NK cell subsets.

Single cell mapping of the human endometrium and first trimester decidua identifies distinct epithelial and stromal cell contributions to fertility

The paper maps the human endometrium and first trimester decidua using single-cell RNA sequencing to identify gene expression changes linked to fertility and implantation.

Genetic survey of biomarkers across pregnancy identifies pregnancy-specialized immune regulation

The paper conducts a genetic analysis of immune biomarkers across pregnancy timepoints, identifying heritable and genome-wide significant associations and highlighting timepoint-specific and pregnancy-unique findings.

Murine implantation chamber formation precedes natural and artificial decidualization

This study shows that implantation chamber formation precedes decidualization in mice, whether induced by natural or artificial stimuli.

HOXA10 is a Temporal Switch in Controlling Decidual Inflammation and Its Dysregulation is Associated with Early Pregnancy Loss

This study identifies HOXA10 as a temporal switch regulating decidual inflammation, showing its dysregulation contributes to early pregnancy loss in mice and humans.

Human embryo implantation involves Syncytin-2/MFSD2A-mediated heterokaryon formation with maternal endometrium

The paper shows that human embryo implantation involves Syncytin-2/MFSD2A-mediated cell fusion between blastoids and endometrial epithelial cells, preventing implantation when MFSD2A is knocked out.

Programmed downregulation of METTL3 is essential for decidualization in both humans and mice

This study shows that reducing METTL3 is necessary for decidualization in humans and mice by maintaining HAND2 expression through m6A modification.

Dynamic Spiral Artery Remodeling in Early Human Pregnancy: An Analysis of Specimens Collected with a Standardized Protocol

A standardized protocol was developed to classify maternal-fetal interface specimens and quantify spiral artery remodeling dynamics in early human pregnancy from gestational weeks 5 to 10.

Cellular and Immune Adaptations at the Maternal-Fetal Interface in Bats

This study uses single-nucleus RNA sequencing and organoids to identify unique placental cell types and immune adaptations in Jamaican fruit bats, revealing species-specific gene programs and attenuated antiviral responses in trophoblasts.

HOXA10-TWIST2 Antagonism Drives Partial Epithelial-to-Mesenchymal transition for Embryo Implantation

The paper identifies a HOXA10-TWIST2 antagonistic circuit that drives partial epithelial-to-mesenchymal transition in the endometrium, essential for embryo implantation.

Pre-implantation non-steroidal anti-inflammatory drug treatment disrupts mouse embryo spacing and post-implantation chamber morphogenesis

This study shows that pre-implantation NSAID treatment in mice disrupts embryo spacing and implantation chamber formation, leading to pregnancy loss.

Comparative analysis of rhesus macaque and human placental organoids highlights evolutionary differences in placentation

This study compares rhesus macaque and human placental organoids to identify evolutionary differences in trophoblast gene expression and differentiation pathways.

The Chromosome 19 miRNA Cluster Guards Trophoblasts Against Overacting Innate Immunity

The paper investigates the role of C19MC microRNAs in trophoblasts, showing they suppress innate immune activation by interfering with TLR3.

Uterine ERBB3 signaling is critical to cultivate stromal environment for functional gland branching

The paper shows that ERBB3 signaling in the uterine stroma is essential for gland branching and fertility, mediated through the ERBB3-IGF1-IGF1R pathway.

Placental immune factors change during the first half of healthy pregnancy

The paper compares gene expression in the first and second trimesters of healthy human pregnancy, identifying immune-related genes that change during placental development.

Genetic Variants in Recurrent Euploid Pregnancy Loss

The paper identifies genetic variants in 30 families with unexplained euploid pregnancy loss, finding monogenic causes in 25% of cases and expanding understanding of early human lethality.

Uterine immune dysregulation after asynchronous transfer induced embryonic apoptosis in mice

This study shows that asynchronous embryo transfer in mice causes uterine immune dysregulation, leading to embryonic apoptosis through DNA damage repair failure and TNFR-mediated pathways.

Excessive immune responses in preterm placental villi compromise trophoblast health

The paper examines immune cell composition and function in placental villi, finding that excessive T cells and cytokines in preterm cases impair trophoblast health.

RO8191, a new compound for initiating embryoimplantation in mice

RO8191 induces embryo implantation in mice by activating the STAT3 pathway and initiating decidualization in specific knockout models.

Cholesterol sulfate prevents maternal-fetal conflict by locally modulating immune reactivity

This study shows that cholesterol sulfate prevents maternal-fetal immune conflict by modulating immune reactivity in pregnant mice and humans.

Extracellular Matrix Reorganization During Endometrial Decidualization

The paper investigates the expression, spatial distribution, and reorganization of extracellular matrix components during endometrial decidualization using imaging and in vitro models.

Fetal inflammatory signals regulate maternal investment in a pregnant marsupial

The paper investigates how fetal inflammatory signals in marsupials influence maternal investment, finding that IL-1 and IL-6 inhibition increases fetal biomass but reduces litter survival.

Obesogenic diet alters decidual differentiation and cell-cell communication in the mouse uterus

This study uses single-cell RNA sequencing to show how an obesogenic diet affects decidual differentiation and cell-cell communication in the mouse uterus.

Mechanosensitive channel PIEZO1 enhances endometrial decidualization via BECN1-dependent autophagy

This study shows that PIEZO1 enhances decidualization by promoting BECN1-dependent autophagy in response to ECM stiffness and cell contraction.