C. Chen

Recurrent hybridization and gene flow shaped Norway and Siberian spruce evolutionary history over multiple glacial cycles

This study examines the evolutionary history of Norway and Siberian spruce, revealing recurrent hybridization and gene flow across glacial cycles, with distinct genetic clusters and refugia shaping their distribution.

A role for JAK2 in mediating cell surface GHR-PRLR interaction

This study investigates the spatiotemporal dynamics of GHR and PRLR on breast cancer cells using dSTORM, revealing that PRLR-GHR interaction is essential for ligand-induced changes in receptor surface availability.

Rapid Development of a Mucosal Nanoparticle Flu Vaccine by Genetic Engineering of Bacteriophage T4 using CRISPR-Cas

This study develops a mucosal nanoparticle flu vaccine using CRISPR-Cas to engineer bacteriophage T4, showing it induces both mucosal and systemic immunity in mice.

A mathematical model for velocity-selective arterial spin labeling

The paper develops a mathematical model for velocity-selective arterial spin labeling (VSASL) to analyze key concepts and predict performance characteristics.

Ubiquitin phosphorylation accelerates protein aggregation and promotes neurodegeneration in the aging brain

This study shows that phosphorylated ubiquitin (pUb) increases with age and contributes to neurodegeneration by impairing proteasomal function and accelerating protein aggregation.

NUCLEOPORIN1 mediates proteasome-based degradation of ABI5 to regulate Arabidopsis seed germination

This study identifies NUP1's role in Arabidopsis seed germination by mediating proteasome-dependent degradation of ABI5.

Comprehensive catalogs for microbial genes and metagenome-assembled genomes of the swine lower respiratory tract microbiome identify the relationship of microbial species with lung lesions

The paper constructs gene catalogs and metagenome-assembled genomes from the swine lower respiratory tract microbiome and identifies associations between microbial species and lung lesions.

The balance between shear flow and extracellular matrix in ovarian cancer-on-chip

This study uses an ovarian tumor-on-chip to investigate how extracellular matrix and shear stress influence tumor cell migration and phenotype, showing ECM's dominant role in migration modes and EMT transition.

Identifying novel radioprotective drugs via salivary gland tissue chip screening

This paper uses a salivary gland tissue chip to screen drugs for radioprotection, identifying novel candidates with nonantioxidant mechanisms.

Juvenile niches select between two distinct development trajectories and symbiosis modes in vent shrimps

The paper shows that juvenile vent shrimps develop into two distinct forms based on symbiosis establishment during subadult transition, influenced by dietary availability.

BRD4 directs mitotic cell division by inhibiting DNA damage

This study shows BRD4 is essential for normal cell growth by regulating cell cycle genes and preventing DNA damage during replication and mitosis.

Identification and Characterization of CtUGT3 as the Key Player of Astragalin Biosynthesis in Safflower

This study identifies CtUGT3 as the key UGT enzyme responsible for astragalin biosynthesis in safflower through metabolomics, transcriptome analysis, and biochemical experiments.

An uncanonical CDK6 activity inhibits cilia function by suppressing axoneme polyglutamylation

This study identifies CDK6 as a regulator of axoneme polyglutamylation by phosphorylating FIP5, leading to impaired cilia function and ciliopathies, and shows CDK6 inhibitors can restore cilia function.

Genome-wide association studies reveal a rapidly evolving candidate avirulence effector in the Cercospora leaf spot pathogen Cercospora beticola

This study identifies a rapidly evolving avirulence effector gene, AvrCR4, in Cercospora beticola using GWAS, showing its association with virulence to the resistance gene BvCR4.

NRF2 activators inhibit influenza A virus replication by interfering with nucleo-cytoplasmic export of viral RNPs in an NRF2-independent manner

This paper shows NRF2 activators inhibit influenza A virus by blocking nuclear export of viral RNPs, independent of NRF2 signaling, through interaction with XPO1 and KEAP1.

Syntheses of Pyrimidine-Modified Seleno-DNAs as Stable Antisense Molecules

This paper synthesizes seleno-modified DNA oligonucleotides and shows they resist nuclease digestion while maintaining RNase H activity.

SIV clearance from neonatal macaques following transient CCR5 depletion

This study shows that targeted depletion of CCR5-expressing cells in neonatal macaques using bispecific antibodies can lead to long-term SIV remission and apparent cure.

Conformational dynamics of the μ-opioid receptor determine ligand intrinsic efficacy

The paper uses biophysical techniques to show how ligand-induced conformational changes in the μ-opioid receptor affect its signaling efficacy.

Functional analysis of Salix purpurea genes support roles for ARR17 and GATA15 as master regulators of sex determination

This study functionally characterizes candidate sex determination genes in Salix purpurea using Arabidopsis, supporting ARR17 and GATA15 as master regulators and identifying downstream transcription factors.

Metabolic Reprogramming via targeting ACOD1 promotes polarization and anti-tumor activity of human CAR-iMACs in solid tumors

This study shows that targeting ACOD1 enhances the pro-inflammatory state and anti-tumor activity of human CAR-iMACs in solid tumors.

Integrin beta4 promotes DNA damage drug resistance in triple-negative breast cancer via TNFAIP2/IQGAP1/Rac1

This study identifies the Integrin β4/TNFAIP2/IQGAP1/RAC1 pathway as a mechanism for DNA damage drug resistance in triple-negative breast cancer.

MdMYB44-like positively regulates salt and drought tolerance via the MdPYL8-MdPP2CA module in apple

This study identifies a regulatory loop involving MdMYB44-like, MdPYL8, and MdPP2CA that enhances salt and drought tolerance in apple by modulating ABA signaling.

Analytical Comparability to Evaluate Impact of Manufacturing Changes of ARX788, an Anti-HER2 ADC in Late-Stage Clinical Development

The paper evaluates the impact of manufacturing changes on ARX788, an anti-HER2 ADC, using ICH Q5E guidelines and shows no adverse effect on product quality.

Development of monoclonal antibody-based blocking ELISA for detecting SARS-CoV-2 exposure in animals

This paper develops a monoclonal antibody-based blocking ELISA for detecting SARS-CoV-2 exposure in animals, achieving high sensitivity and specificity across multiple species.

Mucus production, host-microbiome interactions, hormone sensitivity, and innate immune responses modeled in human cervix chips

This paper develops human cervical Organ Chip models to study mucus production, host-microbiome interactions, and immune responses, showing they mimic in vivo conditions and respond to microbiome changes.

Lack of neutralizing antibodies against the current circulating influenza viruses during the Omicron outbreak in Hong Kong

The paper reports low neutralizing antibody levels against influenza A H1N1 and H3N2 viruses in adults during the Omicron outbreak, emphasizing the need for influenza vaccination.

UPF3A is a ubiquitously expressed NMD factor among mouse tissues

The paper quantifies UPF3A and UPF3B expression in mouse tissues, finding UPF3A is ubiquitously expressed, contradicting previous assumptions of limited expression.

Radioprotective drug screening in a salivary gland tissue chip.

The paper develops a tissue chip platform to screen radioprotective drugs for salivary gland protection and identifies lead compounds with potential radioprotective effects.

Epoxyeicosatrienoic acids and sEH inhibition prevent cardiac dysfunction in CVB3-induced myocarditis by positively regulating type I interferon signaling

This study shows that EETs and sEH inhibitors prevent CVB3-induced myocarditis by enhancing type I interferon signaling and improving viral resistance.

Homeostatic control of an iron repressor in a GI tract resident

The paper shows that Hap43, an iron-responsive transcription factor, is degraded under high iron conditions in C. albicans, leading to antioxidant gene activation and enhanced gut colonization.