F. Wang

Improving the specificity of adenine base editor using high-fidelity Cas9

This study improves the specificity of adenine base editor ABE7.10 by replacing SpCas9 with high-fidelity Cas9 variants, showing reduced off-target activity in four test sites.

Molecular and cellular phenotypic differences distinguish murine syngeneic models from human tumors

This study identifies molecular and cellular differences between murine syngeneic tumor models and human tumors, highlighting limitations in using syngeneic models for immunotherapy research.

Reaction mechanisms of Pol IV, RDR2 and DCL3 drive RNA channeling in the siRNA-directed DNA methylation pathway

General and robust covalently linked graphene oxide affinity grids for high-resolution cryo-EM

This paper develops covalently linked graphene oxide affinity grids for cryo-EM, enabling high-resolution reconstructions by preventing particle denaturation and aggregation.

A role for Toxoplasma gondii chloroquine resistance transporter in bradyzoite viability and digestive vacuole maintenance

This study shows that the Toxoplasma gondii chloroquine resistance transporter (TgCRT) is essential for maintaining the digestive vacuole and bradyzoite viability, suggesting it as a potential target for treating chronic Toxoplasma infection.

Development of rice conidiation media for Ustilaginoidea virens

This paper develops rice tissue media to enhance conidiation of Ustilaginoidea virens, improving pathogenicity testing and genetic analysis for false smut resistance.

Comparative analysis of the Accelerated Aged seed transcriptome profiles of maize CSSLs (I178 and X178)

The paper compares transcriptome profiles of maize CSSLs I178 and X178 under accelerated ageing to identify genes and alternative splicing events associated with seed longevity.

A weighted sequence alignment strategy for gene structure annotation lift over from reference genome to a newly sequenced individual

GEAN improves gene structure annotation lift over from a reference genome to newly sequenced individuals by addressing alignment inconsistencies through a weighted dynamic programming algorithm.

Engineering acetyl-CoA metabolic shortcut for eco-friendly production of polyketides triacetic acid lactone in Yarrowia lipolytica

This paper engineers an acetyl-CoA metabolic shortcut in Yarrowia lipolytica to efficiently produce triacetic acid lactone from acetic acid, achieving a 8.5-fold increase in titer and 31.9% of theoretical yield.

Integrated RNA and metabolite profiling of urine liquid biopsies for prostate cancer biomarker discovery

The paper identifies urine-enriched RNAs and metabolites in prostate cancer patients and normal individuals, revealing altered glutamate metabolism and TCA cycle in cancer cells.

Integrated multi-omics analysis to study the effects of simulated weightlessness on rhesus macaques (Macaca mulatta)

This study uses multi-omics analysis to examine the effects of simulated weightlessness on rhesus macaques, identifying molecular changes in blood, muscle, brain regions, and fecal samples.

Classifying Non-Small Cell Lung Cancer Histopathology Types and Transcriptomic Subtypes using Convolutional Neural Networks

This study uses convolutional neural networks to classify non-small cell lung cancer histopathology types and transcriptomic subtypes using whole-slide images from The Cancer Genome Atlas.

The study on the mechanism of \"oil-spilling\" of wolfberry (Lycium barbarum)fruits during storage

The paper investigates the mechanism of 'oil-spilling' in wolfberry fruits during storage, finding that increased water content, reduced POD activity, and elevated MDA levels contribute to cell damage and lipid peroxidation.

Characterization and Variation of the Rhizosphere Fungal Community Structure of Cultivated Tetraploid Cotton

This study characterizes the rhizosphere fungal community structure of tetraploid cotton and finds it varies with soil type, cotton genotype, and developmental stage.

Quantitative Analysis of Interactive Behavior of Mitochondria and Lysosomes Using Structured Illumination Microscopy

The paper introduces an M-value to quantify mitochondria-lysosome contact and mitophagy using structured illumination microscopy, finding distinct M-value ranges for these processes.

NudCL2 is an Hsp90 cochaperone to regulate sister chromatid cohesion by stabilizing cohesin subunits

This study identifies NudCL2 as a cochaperone that stabilizes cohesin subunits by modulating Hsp90 ATPase activity, preventing mitotic defects and sister chromatid separation.

Root Colonization and Growth Promotion of Soybean, Wheat and Chinese Cabbage by Bacillus cereus YL6

This study shows that Bacillus cereus YL6 promotes growth of soybean, wheat, and Chinese cabbage by solubilizing phosphorus and producing plant hormones, while also colonizing plant roots.

Super-Resolution Tracking of Mitochondrial Dynamics with An Iridium(III) Luminophore

The paper develops an iridium(III) dye for tracking mitochondrial dynamics under structured illumination microscopy, revealing new insights into mitochondria-lysosome interactions.

Glycoprotein 3 of porcine reproductive and respiratory syndrome virus exhibits an unusual hairpin-like membrane topology

This paper investigates the membrane topology of GP3 in PRRSV, showing it has an unusual hairpin-like structure that explains its partial secretion from cells.

A simple and robust procedure for preparing graphene-oxide cryo-EM grids

This paper describes a method for preparing graphene-oxide cryo-EM grids that are suitable for high-resolution single particle cryo-EM.

Multi-hierarchical Profiling the Structure-Activity Relationships of Engineered Nanomaterials at Nano-Bio Interfaces

This study develops a multi-hierarchical nano-SAR assessment for Fe2O3 nanomaterials, revealing how their properties influence bio-effects like cell migration and inflammation.

Microtubule acetylation is required for mechanosensation in Drosophila

This study shows that microtubule acetylation via dTAT is essential for mechanosensation in Drosophila, affecting touch, gravity, and sound responses but not thermal sensing.

USP7 cooperates with NOTCH1 to drive the oncogenic transcriptionalprogram in T cell leukemia

This study identifies USP7 as a key driver of T-cell leukemia by stabilizing NOTCH1 and JMJD3, showing USP7 inhibition blocks leukemia growth and suggests it as a therapeutic target.

MicroRNAs from the parasitic plant Cuscuta campestris target host messenger RNAs

This study identifies microRNAs from the parasitic plant Cuscuta campestris that target host mRNAs, leading to mRNA cleavage and reduced accumulation, and suggests they may function as virulence factors.