F. Wang

Genome-Wide Mapping of Cisplatin Damaged Gene Loci

This study maps cisplatin-damaged gene loci and identifies key pathways and targets, revealing SPAG9 as a potential therapeutic target for testicular cancer.

Single-cell transcriptome analysis of the immunosuppressive effect of differential expression of tumor PD-L1 on responding TCR-T cells

The paper assesses how tumor PD-L1 levels impact TCR-T cell function and anti-PD-(L)1 efficacy using single-cell RNA sequencing and cellular assays.

Crystal structure of steroid reductase SRD5A reveals conserved steroid reduction mechanism

The paper reports the crystal structure of PbSRD5A and provides biochemical insights into the conserved mechanism of steroid 5-reductase catalysis.

An Antioxidant Enzyme Therapeutic for COVID-19

This paper describes a catalase-based therapeutic for COVID-19 that reduces oxidative stress and cytokine production in human and animal models without toxicity.

Single-cell screening of SARS-CoV-2 target cells in pets, livestock, poultry and wildlife

The paper screens SARS-CoV-2 target cells across 11 animal species using single-cell transcriptomes, finding higher proportions in cats and detecting them in multiple pig cell types.

Structure Basis for Inhibition of SARS-CoV-2 by the Feline Drug GC376

The paper determines the structure of SARS-CoV-2 Mpro and shows how GC376 inhibits its catalytic site, supporting its use as an antiviral drug.

Bidirectional introgression between Betula tianshanica and Betula microphylla and its implications for conservation

The paper uses molecular markers and ecological niche models to study introgression between Betula tianshanica and Betula microphylla, finding bidirectional gene flow with implications for conservation.

Polycomb contraction differentially regulates terminal human hematopoietic differentiation programs

The paper shows that H3K27me3 chromatin state changes are critical for terminal differentiation in human hematopoiesis, being retained in lymphoid cells but lost in monocytes and erythroblasts.

Electron microscopic observation of infected CCB and whole genome analysis of Koi herpesvirus isolate GY01

The paper describes electron microscopy of KHV GY01 infected cells and whole genome analysis to study its characteristics and phylogenetic relationships with other KHV strains.

YTHDF1 drives intestinal immune response against bacterial infection

This study identifies YTHDF1 as a key regulator of intestinal immune responses against bacterial infection by modulating TRAF6 mRNA translation through m6A methylation.

Optimizing mevalonate pathway for squalene production in Yarrowia lipolytica

This study engineers Yarrowia lipolytica to produce squalene by optimizing the mevalonate pathway, achieving a 28-fold increase in squalene yield.

Systematic analysis of aberrances of ferroptosis reveals its potential functional roles in cancer

This study systematically analyzes ferroptosis in cancer using TCGA data, finding that ferroptosis-related genes are aberrantly expressed and that FPI is associated with prognosis and drug sensitivity.

Metabolomic markers of colorectal tumor with different clinicopathological features

The paper identifies metabolic subtypes of colorectal cancer using metabolomics and finds correlations between these subtypes and clinical outcomes.

Inhibition of the av integrin-TGF-b axis improves natural killer cell function against glioblastoma stem cells

The paper shows that inhibiting the integrin-TGF-β axis enhances NK cell function against glioblastoma stem cells, suggesting it as a therapeutic target.

Potentiating the anti-tumor response of tumor infiltrated T cells by NAD+ supplementation

NAD+ supplementation enhances T cell activation and tumor-killing capacity in immunotherapies.

A role for keratins in supporting mitochondrial organization and function in skin keratinocytes

This study shows that keratins K6 and K16 regulate mitochondrial structure, function, and dynamics in keratinocytes, contributing to oxidative stress in pachyonychia congenita.

Reactive oxygen species as important regulators of cell division

This study investigates the role of reactive oxygen species (ROS) in plant cell division and cold stress adaptation, finding that ROS influence cell wall stiffness and regulate division rates in Brassica napus.

TipQAD: an automated tool for quantifying apical fluorescence dynamics in tip-growing cells

TipQAD quantifies spatiotemporal fluorescence dynamics in tip-growing cells, providing accurate measurements of FP-labeled proteins in cytoplasm and plasma membrane.

Clonal Evolution of Acute Myeloid Leukemia Revealed by High-Throughput Single-Cell Genomics

This study uses single-cell DNA sequencing to analyze clonal diversity in AML, revealing mutation co-occurrence, mutual exclusivity, and evolutionary patterns linked to treatment resistance and poor prognosis.

Integrated profiling of single cell epigenomic and transcriptomic landscape of Parkinson's disease mouse brain

This study profiles single-cell epigenomic and transcriptomic data from Parkinson's disease mouse brain to identify early biomarkers and cellular contributions to disease pathology.

The photoreceptor UVR8 mediates the perception of both UV-B and UV-A wavelengths up to 350 nm of sunlight with responsivity moderated by cryptochromes

This study shows UVR8 mediates UV-B and UV-A responses in Arabidopsis, with CRYs required for longer UV-A wavelengths, and highlights the need for plant-specific UV waveband definitions.

A Refined View of Airway Microbiome in Chronic Obstructive Pulmonary Disease at Species and Strain-levels

The paper analyzes the airway microbiome in COPD patients at species and strain levels, revealing intra-genus diversity linked to inflammatory phenotypes and clinical outcomes.

Two distinct mechanisms of small molecule inhibition of LpxA acyltransferase essential for lipopolysaccharide biosynthesis

The paper identifies two distinct mechanisms by which small molecules inhibit LpxA acyltransferase, a key enzyme in lipopolysaccharide biosynthesis.

Two distinct mechanisms of small molecule inhibition of LpxA acyltransferase essential for lipopolysaccharide biosynthesis

This study identifies two small-molecule inhibitors of LpxA, revealing distinct inhibition mechanisms and highlighting compound 2's improved properties for antibacterial development.

Seasonal Variation in the Internet Searches for Cancer Recurrence: An Infodemiological Study

This study uses internet search data to show seasonal variation in cancer recurrence queries, with peaks in early summer (northern hemisphere) and late summer (southern hemisphere).

Allosteric coupling between alpha-rings of the 20S proteasome

The paper shows that ATPase binding at one end of the 20S proteasome allosterically opens the opposite gate, promoting symmetric and asymmetric proteasome configurations.

SPOP Promotes Ubiquitination and Degradation of MyD88 to Suppress the Innate Immune Response

This study shows SPOP promotes ubiquitination and degradation of MyD88, suppressing innate immune responses and reducing susceptibility to Salmonella typhimurium infection.

Bone morphogenetic protein 9 induces osteogenic differentiation of germ cell 1 spermatogonial cells

This study shows BMP9 induces osteogenic differentiation in GC-1spg cells through upregulated markers and in vivo bone formation.

Amino and PEG-Amino Graphene Oxide Grids Enrich and Protect Samples for High-resolution Single Particle Cryo-electron Microscopy

This paper introduces amino and PEG-amino functionalized graphene oxide grids to improve sample concentration, distribution, and protection for cryo-EM.

On the delay in propagation of action potentials

The paper reanalyzes experimental data to show that action potential propagation delays are small compared to signal duration, suggesting a new physical model for neural signal communication.