G. Chen

Long noncoding RNA VENTHEART is required for cardiomyocyte specification and function

This study identifies VENTHEART as a lncRNA essential for cardiomyocyte specification, maturation, and function, with potential relevance to heart disease.

Remdesivir Metabolite GS-441524 Efficiently Inhibits SARS-CoV-2 Infection in Mouse Model

This study shows that GS-441524, a metabolite of remdesivir, effectively inhibits SARS-CoV-2 in cell cultures and mice, suggesting it may contribute to remdesivir's antiviral activity.

CD8+ T cell epitope variations suggest a potential antigen presentation deficiency for spike protein of SARS-CoV-2

The paper identifies HLA-A2 restricted T cell epitopes in SARS-CoV-2 spike protein and finds that variations in these epitopes may reduce T cell activation and contribute to immune escape.

Unique intramolecular oxidative rearrangement N-nitrosation mechanism of non-heam iron-containing enzyme SznF

This paper investigates the catalytic mechanism of SznF, revealing an unusual N-nitrosation pathway involving electron shuttling without high-valent iron species.

Infection and chronic disease activate a brain-muscle signaling axis that regulates muscle performance

This study identifies a brain-muscle signaling axis activated by infections and chronic diseases that reduces muscle performance through cytokine-dependent mechanisms.

Interactive regulation between aliphatic hydroxylation and aromatic hydroxylation of thaxtomin D in TxtC, a theoretical investigation

This paper investigates how TxtC catalyzes sequential hydroxylation of thaxtomin D, revealing that aliphatic hydroxylation is preferred due to lower energy barriers and conformational changes induced by intermediate hydroxyl groups.

The jasmine (Jasminum sambac) genome and flower fragrances

This study presents the first de novo genome of Jasminum sambac and identifies gene clusters and pathways involved in flower fragrance biosynthesis.

Association of CD44-/CD24- Breast Cancer Cells with Late Stage Tumor Recurrence

This study links CD44-/CD24- breast cancer cells to late-stage tumor recurrence and identifies RHBDL2 as a regulator of CSC conversion.

A-to-I mRNA editing in a ferric siderophore receptor improves competition for iron in Xanthomonas oryzae

This study shows that A-to-I RNA editing in Xanthomonas oryzae enhances iron uptake by modifying the xfeA gene, improving bacterial competitiveness in iron-limited environments.

Furfural residues as soil amendments for long-term seed corn production: effects on community composition and diversity of rhizosphere microbiota

This study examines how furfural residue amendments affect rhizosphere microbiota diversity and composition in long-term maize monocropping, showing increased beneficial microbes and reduced pathogens.

Ribonucleotide reductase, a novel target for gonorrhea

This study identifies two novel inhibitors of Neisseria gonorrhoeae that target ribonucleotide reductase, showing efficacy against multidrug-resistant strains in a mouse model.

ACE2-Targeting Monoclonal Antibody as Potent and Broad-Spectrum Coronavirus Blocker

This paper reports a monoclonal antibody, 3E8, that blocks multiple coronaviruses by targeting ACE2, showing broad-spectrum activity against SARS-CoV-2 variants and other coronaviruses.

The evolution of stomatal traits along the trajectory towards C4 photosynthesis

This study examines how stomatal traits evolve from C3 to C4 photosynthesis in Flaveria species, finding a stepwise change with significant shifts in stomatal density and size.

Activated Expression of Master Regulator MYB31 and of Capsaicinoid Biosynthesis Genes Results in Capsaicinoid Biosynthesis and Accumulation in the Pericarp of the Extremely Pungent Capsicum chinense

The paper shows that MYB31 activation and CBG expression in the pericarp of C. chinense leads to high capsaicinoid accumulation, explaining the extreme pungency of these peppers.

Transport of Alzheimer's Associated Amyloid-β Catalyzed by P-glycoprotein

This study shows P-glycoprotein actively transports amyloid-β proteins, suggesting a role in Alzheimer's disease progression.

Evolution of co-regulatory network of C4 metabolic genes and TFs in the genus Flaveria: go anear or away in the intermediate species?

This study constructs TF co-regulatory networks for C4 metabolic genes across four Flaveria species, revealing species-specific co-regulations and evolutionary rewiring of TF networks during C4 photosynthesis development.

A proof of concept for neutralizing antibody-guided vaccine design against SARS-CoV-2

A cocktail of neutralizing antibodies targeting SARS-CoV-2 spike protein's NTD and RBD, when used as immunogens in rabbits, elicited strong protective immune responses.

Alternate models of acute dyslipidemia reveal divergent pathways upon atherosclerosis initiation

This study uses two novel mouse models to show that different pathways lead to atherogenesis, with APOE inhibiting inflammation and CD8 T cells regulating aortic response.

Regulations of expressions of rat/human sulfotransferases (SULTs) by anti-cancer drug, nolatrexed and micronutrients.

This study examines how the anti-cancer drug nolatrexed and micronutrients like folic acid affect sulfotransferase (SULT) expressions in rats and HepG2 cells.

Long non-coding RNA LINC00152 plays an oncogenic role via targeting STAT3 and c-MYC signaling in esophageal adenocarcinoma

This study investigates LINC00152's role in esophageal adenocarcinoma, finding it promotes tumor progression via STAT3 and c-MYC signaling and suggests it as a biomarker and therapeutic target.

Dynamics of mcr-1 prevalence and mcr-1-positive Escherichia coli after the cessation of colistin use as a feed additive for animals in China: a prospective cross-sectional and whole genome sequencing based molecular epidemiological study

This study tracks the decline of mcr-1 prevalence and genetic changes in mcr-1-positive Escherichia coli after China banned colistin use in animal feed.

Enzyme stoichiometry indicates the variation of microbial nutrient requirements at different soil depths in subtropical forests

The study examines enzyme activities and microbial nutrient limitation across soil depths in subtropical forests, finding co-limitation by C and P rather than N.

Transcriptional Differences of Peanut (Arachis hypogaea L.) Seeds in the Fresh-harvest, After-ripened and Just-germinated States: insights into regulatory networks of seed dormancy-release and germination

This study identifies transcriptional changes in peanut seeds during dormancy release and germination, revealing key pathways and hormone-related genes involved in these processes.

Infection risk and extensive parental care govern the molecular evolution of Toll-like receptors in birds.

This study examines the molecular evolution of Toll-like receptor genes in birds, finding that positive selection is linked to migration, parental care, and body size.

Diverse noncoding mutations contribute to deregulation of cis-regulatory landscape in pediatric cancers

This study identifies and characterizes noncoding mutations in pediatric cancers using a computational framework and experimental validation, revealing their role in deregulating cis-regulatory landscapes.

Phylogeny, transposable element and sex chromosome evolution of the basal lineage of birds

This study investigates sex chromosome evolution in paleognath birds, finding that tinamous have higher substitution rates and unique evolutionary strata without chromosomal inversion.

Considering founding and variable genomes is critical in studying polyploid evolution

The paper compares subgenome asymmetry in artificial and natural allopolyploid genotypes, finding that variable genome components influence subgenome differences and suggest their consideration in polyploid evolution studies.

Evolutionary changes of phosphoenolpyruvate transporter (PPT) during the emergence of C4 photosynthesis

This study examines evolutionary changes in the phosphoenolpyruvate transporter (PPT) during C4 photosynthesis emergence, identifying shifts in expression, light responsiveness, and cis-element acquisition in PPT1.

Biocontrol of PGPR strain Bacillus amyloliquefaciens Ba168 against Phytophthora nicotianae on tobacco

This paper evaluates the biocontrol potential of PGPR strain Ba168 against tobacco black shank caused by Phytophthora nicotianae, showing it is effective but slightly less than a chemical mixture.

Use of solvent extraction-indigenous microbial degradation technology to repair soils contaminated by high concentrations of mechanical oil

This study uses solvent extraction combined with indigenous microbial degradation to remediate oil-contaminated soil, showing improved soil quality and plant growth.