H. Yu

Bovine milk glycoproteins inhibit SARS-CoV-2 and influenza virus co-infection

This study shows that galactosylated glycoproteins from bovine milk inhibit both SARS-CoV-2 and influenza virus by blocking their interaction with ACE2.

CUR(E)ating a New Approach to Study Fungal Effectors and Enhance Undergraduate Education through Authentic Research

This paper describes a CURE course focused on fungal effectors that enhances undergraduate education through authentic research and real-world problem-solving.

Brainstem Dbh+ Neurons Control Chronic Allergen-Induced Airway Hyperreactivity

This study identifies Dbh+ neurons in the brainstem as critical for chronic allergen-induced airway hyperreactivity through molecular, anatomical, and functional analyses.

Cancer relevance of circulating antibodies against LINE-1 antigens in humans

The paper detects higher levels of anti-LINE-1 protein antibodies in cancer patients compared to healthy individuals, suggesting potential diagnostic value for early cancer detection.

Chromosome-level genomes of multicellular algal sisters to land plants illuminate signaling network evolution

The paper sequenced four Zygnematophyceae algal genomes to study signaling network evolution, finding expanded genes for multicellularity and environmental response.

Single-cell transcriptomic landscape deciphers novel olfactory neuroblastoma subtypes and intratumoral heterogeneity

This study uses single-cell RNA sequencing to identify novel subtypes and intratumoral heterogeneity in olfactory neuroblastoma.

Nanofluidic Device for Manipulation and Modification of DNA by Proteins

The paper introduces a nanofluidic device that enables real-time combinatorial exchange of buffers and dynamic DNA manipulation to study protein-DNA interactions.

Pretrained language models and weight redistributionachieve precise kcat prediction

This paper introduces PreKcat, a model that accurately predicts kcat values using pretrained language models and weight redistribution, outperforming existing methods.

Physiological adaptation of sulfate reducing bacteria in syntrophic partnership with anaerobic methanotrophic archaea

This study examines the metabolic adaptations of sulfate-reducing bacteria in syntrophic partnerships with methanotrophic archaea, revealing unique evolutionary changes in protein pathways.

An FcRn-targeted mucosal vaccine against SARS-CoV-2 infection and transmission

This study develops an FcRn-targeted mucosal vaccine that reduces SARS-CoV-2 infection and transmission in mice and hamsters by inducing protective immune responses in the airways.

Proliferative Exhausted CD8 T Cells Exacerbate Long-lasting Anti-tumor Effects in Human Papillomavirus Positive Head and Neck Squamous Cell Carcinoma

The paper identifies a proliferative exhausted CD8+ T cell cluster in HPV-positive HNSCC that correlates with better patient survival and suggests potential therapeutic implications.

CD3e-immunotoxin spares CD62L(lo) Tregs and reshapes organ-specific T-cell composition by preferentially depleting CD3e(hi) T cells.

Matrix Softening Controls Stretch-Induced Cellular Memory and Fibroblast Activation

This study shows that matrix softening influences stretch-induced cellular memory and fibroblast activation, with a model predicting activation levels based on ECM properties.

Controllable self-replicating RNA vaccine delivered intradermally elicits predominantly cellular immunity

This paper develops a temperature-controlled self-replicating RNA vaccine that elicits cellular immunity and can be used as a pan-coronavirus booster.

DNA capture and loop extrusion dynamics by cohesin-NIPBL

This study uses high-speed AFM to show cohesin-NIPBL captures DNA through arm extension and initiates loop extrusion without ATP hydrolysis, revealing mechanisms of DNA binding and loop formation.

Development of highly potent non-covalent inhibitors of SARS-CoV-2 3CLpro

This study develops a potent non-covalent inhibitor of SARS-CoV-2 3CLpro, showing effective antiviral activity in human cells and animal models.

Dissecting the subtropical adaptation traits and cuticle synthesis pathways via the genome of the subtropical blueberry Vaccinium darrowii

This paper reports the genome assembly of Vaccinium darrowii, identifies adaptation traits, and delineates cuticle biosynthesis pathways to aid blueberry breeding.

Characterization of a KDM5 Small Molecule Inhibitor with Antiviral Activity against Hepatitis B Virus

This study identifies a KDM5 inhibitor with anti-HBV activity in vitro but not in vivo, highlighting challenges in translating epigenetic therapies to viral infections.

A non-destructive approach for measuring rice panicle-level photosynthetic responses using 3D-image reconstruction

This paper develops a non-destructive method to measure rice panicle-level photosynthetic responses using 3D imaging and gas exchange analysis, revealing differential responses to heat stress between two rice genotypes.

Topological defects govern mesenchymal condensations, offering a morphology-based tool to predict cartilage differentiation

The paper shows that topological defects in cellular swirl patterns predict cartilage differentiation potential of mesenchymal stromal cells.

Alteration of Soil Bacteriome by Prolonged Exposure to Metal Oxide Nanoparticles

This study examines how prolonged exposure to metal oxide nanoparticles affects soil bacterial communities, finding reduced diversity and shifts in bacterial abundance and taxonomy.

Adipokine C1q/Tumor necrosis factor-related protein 3 (CTRP3) Attenuates Intestinal Inflammation via Histone Deacetylase Sirtuin 1 (SIRT1)/NF-κB Signaling

This study shows that CTRP3 reduces intestinal inflammation in colitis models and IBD patients by modulating SIRT1/NF-κB signaling to suppress pro-inflammatory cytokines.

Profiling the size-dependent heterogeneity of membrane proteins in a mixed population of small extracellular vesicle for potential cancer diagnosis

This study profiles size-dependent membrane protein heterogeneity in small EVs to improve cancer diagnosis accuracy using a novel single EV enumeration approach.

Cell transcriptomic atlas of the non-human primate Macaca fascicularis

The paper presents a single-cell transcriptomic atlas of Macaca fascicularis, identifying cell interactions and disease associations.

Inflammation induced Vascular Smooth Muscle Cell expressing Angiopoietin-like 2 to promote the development of abdominal aortic aneurysm

This study shows that Angptl2 in vascular smooth muscle cells promotes abdominal aortic aneurysm development under inflammation.

Structure of phage lambda Red-beta(177) annealase shows how it anneals DNA strands during single-strand annealing homologous DNA recombination

This paper determines the structure of Red-beta annealase using cryo-EM and proposes a mechanism for DNA strand annealing during homologous recombination.

Lipolysis of bone marrow adipocytes is required to fuel bone and the marrow niche during energy deficits

This study shows that BMAd lipolysis is essential for maintaining myelopoiesis, bone mass, and bone regeneration during energy deficits.

Fragment-Based Ligand Generation Guided By Geometric Deep Learning On Protein-Ligand Structure

The paper develops a method to expand small fragment-like molecules bound to protein pockets into larger drug-like molecules using geometric deep learning.

Intergenerational transfer and sex differences of DNA methylation patterns in the Pacific oyster (Crassostrea gigas)

This study investigates DNA methylation inheritance in Pacific oysters, finding that half of parental methylation differences are passed to offspring and revealing sex-specific methylation patterns linked to Rho signaling.

Sex-specific transcription and DNA methylation landscapes of the Asian citrus psyllid, a vector of huanglongbing pathogens.

The paper identifies the X chromosome of the Asian citrus psyllid and compares transcription and DNA methylation between male and female adults, finding sex-specific patterns and no direct link between methylation and gene expression.