Wei Li

DNACSE: Enhancing Genomic LLMs with Contrastive Learning for DNA Barcode Identification

DNACSE improves DNA barcode identification by fine-tuning DNA language models with contrastive learning, achieving higher accuracy and clustering performance than existing methods.

A stem cell knockout village reveals lineage rewiring and a non-canonical islet cell fate in monogenic diabetes

This study uses a knockout village framework to analyze how mutations in diabetes genes alter pancreatic beta cell development, revealing non-canonical cell fate shifts and identifying ISL1 as a key regulator.

Elevated neuronal TAF15 expression leads to FTD-like phenotype

This study shows that elevated TAF15 expression in neurons causes oxidative stress, neurotoxicity, and FTD-like behaviors, which can be reversed by antioxidants.

Ligase-mediated programmable genomic integration (L-PGI): an efficient site-specific gene editing system that overcomes the limitations of reverse transcriptase-based editing systems

This paper introduces L-PGI, a ligase-mediated gene editing system that enables efficient and precise genomic integration in both dividing and nondividing cells, overcoming limitations of reverse transcriptase-based methods.

The Generalizability of Cortical Area Parcellations Across Early Childhood

This study parcellates the cerebral cortex in toddlers using functional connectivity and shows high reproducibility across ages, with area boundaries more similar to adults than neonates.

Genome-wide profiling of highly similar paralogous genes using HiFi sequencing

The paper develops Paraphase, a HiFi-based method to resolve highly similar paralogous genes, revealing genetic diversity and de novo events in segmental duplications.

Beyond enumeration: Phenotype independent "labeling-capture-release" process enabling precise detection of circulating tumour cells and downstream applications

This paper introduces a labeling-capture-release method for isolating circulating tumor cells from blood samples with high efficiency and accuracy, enabling downstream applications.

xOmicsShiny: an R Shiny application for cross-omics data analysis and pathway mapping

xOmicsShiny is an R Shiny application that enables cross-omics data analysis and pathway mapping with visualization and analytical tools.

Low RT-based Genome Editing Fidelity in Mouse Hepatocytes: Challenges and Solutions

The paper identifies low fidelity in RT-based genome editing in non-dividing mouse hepatocytes and proposes solutions using neonatal mice and transgenic models.

A novel bifunctional peptide VAMP mined from hemp seed protein hydrolysates improves glucose homeostasis by inhibiting intestinal DPP-IV and increasing the abundance of Akkermansia muciniphila

The paper identifies a novel tetrapeptide VAMP from hemp seed protein hydrolysates that inhibits DPP-IV and increases Akkermansia muciniphila abundance, improving glucose homeostasis in obese mice.

A small-molecule TrkB ligand improves dendritic spine phenotypes and atypical behaviors in female Rett syndrome mice

This study shows that the small-molecule TrkB agonist LM22A-4 improves dendritic spine morphology and reduces aggressive behaviors in female Rett syndrome mice.

A novel antidepressant acting via allosteric inhibition of GluN2D-incorporated NMDA receptors at GABAergic interneurons

The paper identifies YY-23, a compound that inhibits GluN2D-containing NMDARs in GABAergic interneurons, showing antidepressant effects in animal models.

Human Identical Sequences of SARS-CoV-2 Promote Clinical Progression of COVID-19 by Upregulating Hyaluronan via NamiRNA-Enhancer Network

This paper identifies human identical sequences in SARS-CoV-2 that upregulate hyaluronan via a miRNA-enhancer network, contributing to cytokine storm and ARDS in COVID-19, suggesting potential therapeutic strategies.

Structural variability and functional association in the epiphytic bacteria assemblies of freshwater macrophytes (Myriophyllum spicatum)

This study investigates how host macrophytes and water body conditions influence epiphytic bacterial community assembly in freshwater environments.

Dual functions of Intraflagellar Transport Protein IFT20 in spermiogenesis: formation of sperm flagella and removal of cytoplasm by autophagy

This study shows that IFT20 is crucial for sperm flagella formation and cytoplasm removal via autophagy in mice.

Global lengthening of 3′ untranslated regions of mRNAs by alternative cleavage and polyadenylation in cellular senescence

This study shows that alternative polyadenylation (APA) leads to longer 3' UTRs in senescent cells, affecting gene regulation through miRNA and RBP binding sites.

Progressive lengthening of 3′ untranslated regions of mRNAs by alternative cleavage and polyadenylation in cellular senescence of mouse embryonic fibroblasts

The paper investigates APA regulation in cellular senescence, finding genes in senescent cells preferentially use distal polyadenylation sites, associated with longer 3′ UTRs and senescence-related pathways.

Exploring functional variation affecting ceRNA regulation in humans

The paper identifies genetic variations affecting ceRNA regulation by analyzing RNA-seq data and GWAS results, revealing new regulatory mechanisms and disease associations.