MicroRNA in disease regulation

Highly-connected, non-redundant microRNAs functional control in breast cancer molecular subtypes

The paper identifies non-redundant microRNAs in breast cancer subtypes and links them to cancer-related biological functions through co-expression networks.

High-throughput miRNA-sequencing of the human placenta: expression throughout gestation

This study uses high-throughput miRNA-sequencing to analyze miRNA expression in first and third trimester human placentae, identifying differentially expressed and stable miRNAs across gestation.

MiR-124 synergism with ELAVL3 enhances target gene expression to promote neuronal maturity

The paper identifies miR-124's role in promoting neuronal maturity by enhancing target gene expression through interaction with ELAVL3.

Comprehensive machine-learning-based analysis of microRNA-target interactions reveals variable transferability of interaction rules across species

The paper uses machine learning to analyze miRNA-target interactions across species, finding that transferability depends on seed family composition and evolutionary distance.

PQN-59 antagonizes microRNA-mediated repression and functions in stress granule formation during C. elegans development

This paper identifies pqn-59 as a factor that antagonizes miRNA-mediated repression and promotes stress granule formation in C. elegans, contributing to regulatory bistability in developmental gene networks.

The stem cell-specific protein TRIM71 inhibits maturation and activity of the pro-differentiation miRNA let-7 via two independent molecular mechanisms

This study identifies two independent mechanisms by which TRIM71 inhibits let-7 miRNA maturation and activity, impacting developmental and oncogenic processes.

miRNA activity inferred from single cell mRNA expression

The paper estimates miRNA activity from single-cell RNA sequencing data by analyzing motif enrichment, validated on bulk and single-cell datasets.

An in silico integrative analysis of hepatocellular carcinoma omics databases shows the dual regulatory role of microRNAs either as tumor suppressors or as oncomirs

The paper performs an in-silico analysis of HCC omics data to show microRNAs can act as both tumor suppressors and oncomirs through complex regulatory interactions.

The Great Deceiver: miR-2392's Hidden Role in Driving SARS-CoV-2 Infection

The paper identifies miR-2392 as a miRNA involved in SARS-CoV-2 infection, showing its role in inflammation, glycolysis, and hypoxia, and develops a miRNA-based therapeutic targeting it.

A non-canonical microRNA derived from the snaR-A non-coding RNA targets a metastasis inhibitor

The paper identifies a Drosha-independent miRNA, miR-snaR, derived from the snaR-A non-coding RNA, which promotes cancer cell migration by targeting NME1.

Systematic in vivo quantification of microRNA affinities

The paper systematically quantifies microRNA affinities in vivo using mouse embryonic stem cells and finds that miRNA target affinities vary widely and correlate with expression levels.

Tumor IsomiR Encyclopedia (TIE): a pan-cancer database of miRNA isoforms

The paper introduces TIE, a database of miRNA isoforms from tumor samples, demonstrating their functional relevance and providing tools for analysis.

GW182 Proteins Restrict Extracellular Vesicle Mediated Selective Export of Used miRNAs In Mammalian Cancer Cells

The paper shows that GW182 proteins restrict the export of used miRNAs via extracellular vesicles in cancer cells, independent of HuR, and that this process is linked to miRNA turnover and cellular senescence.

Exploration of endogenous miRNA-200b/c activity and regulation through a functional dual fluorescence reporter

The paper uses a fluorescent sensor and CRISPR-Cas9 screening to study miR-200b/c activity and regulation during EMT, identifying upstream regulators and a role for metabolic enzymes.

miTAR: a hybrid deep learning-based approach for predicting miRNA targets

The paper introduces miTAR, a hybrid deep learning model for miRNA target prediction, achieving higher accuracy than existing methods on two datasets.

Endoribonuclease activity of XRN-2 is critical for RNA metabolism and survival of Caenorhabditis elegans

This study characterizes the endoribonuclease activity of XRN-2 in C. elegans, showing its critical role in miRNA turnover and survival of dauer worms, and its importance in rRNA maturation for translation.

Tissue micro-RNAs associated with colorectal cancer prognosis: a systematic review

This study identifies differentially expressed tissue micro-RNAs associated with prognosis in colorectal cancer through a systematic review of 115 articles.

A cohort of Caenorhabditis species lacking the highly conserved let-7 microRNA

The paper identifies Caenorhabditis species lacking the let-7 microRNA and shows the heterochronic gene network remains functional without it.

The developmentally-timed decay of an essential microRNA family is seed sequence-dependent

The paper shows that the decay of the mir-35 miRNA family in C. elegans is seed sequence-dependent and selectively regulates all members of the family during development.

miRCoop: Identifying Cooperating miRNAs via Kernel Based Interaction Tests

miRCoop identifies synergistic miRNA pairs that induce strong repression on target mRNAs when combined, using kernel-based interaction tests and applies it to kidney tumor data to find 66 putative triplets.

A multifaceted microRNA turnover complex from Caenorhabditis elegans

The paper identifies a microRNA turnover complex in C. elegans and shows it can switch between ATP-dependent and ATP-independent modes of operation.

feamiR: Feature selection based on Genetic Algorithms for predicting miRNA-mRNA interactions

feamiR uses genetic algorithms to select features for predicting miRNA-mRNA interactions, improving accuracy by analyzing seed, compensatory, and flanking regions.

From miRNA target gene network to miRNA function: miR-375 might regulate apoptosis and actin dynamics in the heart muscle via Rho-GTPases-dependent pathways

Viral miRNAs Confer Survival in Host Cells by Targeting Apoptosis Related Host Genes

The paper identifies that viral miRNAs target host apoptosis-related genes to suppress cell death, enhancing viral survival.

Chameleon microRNAs in breast cancer: their elusive role as regulatory factors in cancer progression

The paper identifies 112 miRNA combinations that accurately distinguish healthy breast tissue from breast carcinoma using a machine learning approach that generates sets of equivalent predictive models.

Translation is required for miRNA-dependent decay of endogenous transcripts.

The paper shows that translation is required for miRNA-dependent transcript decay, as non-translated lncRNAs are minimally affected by miRNA loss, while translated transcripts are destabilized.

A pan-cancer atlas of somatic mutations in miRNA biogenesis genes

The paper analyzes somatic mutations in miRNA biogenesis genes across cancer types and identifies their impact on miRNA levels and patient survival.

Hypoxia-induced miR-92a regulates p53 signalling pathway and apoptosis by targeting calcium-sensing receptor in Genetically Improved Farmed Tilapia (Oreochromis niloticus)

This study shows miR-92a regulates apoptosis in tilapia liver under hypoxia by targeting CaSR, reducing p53 and caspase-3/8 expression and alleviating liver damage.

MicroRNA-210 Knockout Alters Dendritic Density and Behavioural Flexibility

This study shows that miR-210 knockout increases dendritic density and behavioural flexibility in mice by altering neuronal metabolism and oxidative stress.

miR-218 in adolescence predicts and mediates vulnerability to stress

This study shows that miR-218 expression in adolescence predicts and mediates vulnerability to stress in adulthood by regulating Dcc expression in the medial prefrontal cortex.