Gut microbiota and health

Translational control of innate barrier defense by the gut microbiota

The gut microbiota enhances translation of innate barrier defense proteins through HDAC5-mediated activation of mTORC1 signaling.

The South American MicroBiome Archive (saMBA): Enriching the healthy microbiome concept by evaluating uniqueness and biodiversity of neglected populations

The paper creates saMBA, a large gut microbiome archive from South America, revealing high biodiversity and uniqueness, and highlights the need for more diverse microbiome research.

Ablation of polysaccharide breakdown in Bacteroides thetaiotaomicron prevents cross-feeding and growth of Salmonella Typhimurium in the mouse gut

This study shows that inhibiting polysaccharide breakdown in Bacteroides thetaiotaomicron reduces cross-feeding and growth of Salmonella Typhimurium in mice.

Sulfoquinovose is exclusively metabolized by the gut microbiota and degraded differently in mice and humans

This study shows that sulfoquinovose is not metabolized by mice or humans but is degraded by gut microbiota, with differences in degradation pathways between mice and humans.

Adolescent girls at familial risk for depression with more advanced adrenarche have altered gut microbiota

The paper examines gut microbiota differences between high- and low-risk adolescents for depression, finding sex-specific links with adrenarche and Prevotella abundance.

Zinc and Cobalt exposure influence Akkermansia muciniphila growth and short-chain fatty acid metabolism

This study examines how zinc and cobalt exposure affects Akkermansia muciniphila growth and short-chain fatty acid production, finding that high cobalt levels reduce growth while zinc increases propionate production.

Gut Microbiota Regulates Exercise-induced Hormetic Modulation of Cognitive Function

The paper shows that moderate exercise improves cognitive function and neurogenesis in mice, but these benefits disappear with higher intensity or duration, and that gut microbiota changes mediate these effects.

Portal bile acids and microbiota along the murine intestinal tract exhibit sex differences in physiology

The paper examines sex differences in gut microbiota and bile acid composition in mice, finding distinct microbial diversity and portal bile acid profiles between males and females.

Microbial Diversity and Ecological Structure of the Gut Microbiota in Children and Adults from an Indigenous Mexican Community

This study examines gut microbiota diversity in an Indigenous Mexican community, finding age and sex-related differences and highlighting unique microbial profiles not commonly seen in Western populations.

Causal relationships between gut microbiome and hundreds of age-related traits: evidence of a replicable effect on ApoM protein levels

The paper investigates causal relationships between gut microbiome traits and age-related phenotypes, finding significant associations with ApoM protein levels and other plasma proteins.

The Impact of Parabacteroides distasonis Colonization on Hosts' Microbiome, Metabolome, Immune Responses, and Diabetes Onset

This paper investigates how Parabacteroides distasonis colonization affects the microbiome, immune responses, and diabetes onset in NOD mice, finding it induces insulitis and activates specific T-cells without causing broad inflammation.

Territorial behavior as a route of social microbial transmission in an asocial mammal

This study shows that territorial intrusions in red squirrels facilitate microbial transmission, increasing gut microbial diversity and similarity among socially associated individuals.

Human gut microbiota subspecies carry implicit information for in-depth microbiome research

This paper defines human gut microbiota at subspecies resolution, identifies disease-associated subspecies, and shows that subspecies-level analysis improves CRC diagnosis compared to species-level methods.

Metagenomic estimation of absolute bacterial biomass in the mammalian gut through host-derived read normalization.

This paper estimates absolute bacterial biomass in the gut using host-derived read normalization from metagenomic data, showing it tracks antibiotic treatment response in mice and humans.

Using low pass whole metagenome sequencing for gut microbiome profiling in an Argentine urban population

This study uses low-pass whole metagenome sequencing to analyze gut microbiome functional capacity and diversity in an Argentine urban population, finding reduced alpha-diversity and impaired metabolic potential in the unscreened cohort.

Rapid remodeling of the human gut microbiome in response to short-term animal product restriction

This study examines how short-term animal product restriction alters the human gut microbiome and host plasma biology in a religiously motivated dietary group.

Maternal diet alters offspring early life host-microbiota communication through goblet cells, resulting in long-lasting diseases susceptibility

This study shows maternal diet affects offspring microbiota and health through goblet cells, leading to long-term disease susceptibility.

Human gut microbiome gene co-expression network reveals a loss in taxonomic and functional diversity in Parkinson's disease

This study uses multi-omics data to reveal reduced taxonomic and functional diversity in the gut microbiome of Parkinson's disease patients.

Butyrate preserves entorhinal-hippocampal spatial coding and blood brain barrier integrity in mice with depleted gut microbiome

This study shows that butyrate supplementation prevents cognitive impairments and blood-brain barrier damage in mice with gut microbiome depletion caused by antibiotics.

Environmental and Maternal Imprints on Infant Gut Metabolic Programming

The paper examines how environmental and maternal factors influence infant gut metabolism through microbiome and metabolome profiling in Bangladeshi mother-infant pairs.

Dual human milk oligosaccharide-fibre utilisation drives gut microbiome selection during weaning

The paper investigates how dual utilization of human milk oligosaccharides and dietary fibers influences gut microbiome selection during weaning.

Protein Malnutrition Facilitates Intestinal Colonization with Highly Resistant Klebsiella pneumoniae

This study shows that protein malnutrition in mice increases susceptibility to intestinal colonization by carbapenem-resistant Klebsiella pneumoniae, likely through reduced secondary bile acids.

Blood-borne immune cells carry low biomass DNA remnants of microbes in patients with colorectal cancer or inflammatory bowel disease

The paper identifies bacterial DNA remnants in blood immune cells of CRC and IBD patients, suggesting microbial translocation via intestinal barrier defects.

Genome scale metabolic modelling of human gut microbes to inform rational community design

This study uses genome-scale metabolic models to design microbial communities that enhance butyrate production through DRC supplementation, showing improved resilience and intervention effectiveness.

Diversity of motility gene signatures distinguishes commensal Clostridiathat elicit divergent host immune responses

The paper identifies distinct motility gene signatures in Clostridia that correlate with divergent immune responses, showing one group promotes inflammation while another induces tolerance.

Extensive novel diversity and phenotypic associations in the dromedary camel microbiome are revealed through deep metagenomics and machine learning

The paper uses deep metagenomics and machine learning to analyze dromedary camel gut microbiomes, revealing novel microbial diversity and strong predictive associations with diet and lifestyle.

Environmental factors drive bacterial degradation of gastrointestinal mucus

This study shows that environmental factors, not glycan utilization, drive bacterial degradation of gastrointestinal mucus, with protease activity and nutrient/oxygen conditions playing key roles.

Examining the composition of gut microbiota in a South African population: a comparative study between type 2 diabetes mellitus patients and non-diabetic individuals

This study compares gut microbiota composition between type 2 diabetes mellitus patients and non-diabetic South Africans, finding distinct microbial profiles and associations with inflammation markers.

Integrative genomic reconstruction reveals heterogeneity in carbohydrate utilization across human gut bifidobacteria

This study reconstructs carbohydrate utilization pathways in human gut bifidobacteria, revealing strain-specific metabolic capabilities and validating them experimentally.

Mucus-associated microbiota consortia: Insights from the advanced TIM-2muc model

The paper introduces TIM-2muc, a novel in vitro model that mimics the mucus-associated microbiome, showing it closely resembles the in vivo MAM and enables non-invasive study of both MAM and luminal microbiome.