Gut microbiota and health

Effects of alcohol on gut microbiome in adolescent and adult MMTV-Wnt1 mice

This study investigates how alcohol affects the gut microbiome in adolescent and adult MMTV-Wnt1 mice and their wild-type counterparts, showing reduced microbiome richness and altered composition.

Evaluating effects of antibiotics across preclinical models of the human gastrointestinal microbiota

This study evaluates how different antibiotics affect gut microbiota in two preclinical models, showing varied impacts across taxa and highlighting model-specific differences in antibiotic susceptibility.

In vitro metabolic interaction network of a rationally designed nasal microbiota community

The paper develops a microbial consortium to study nasal microbiota metabolic interactions and finds that most interactions are negative, driven by sugar co-depletion and leading to competitive hierarchies.

ATOMIC: A graph attention neural network for ATOpic dermatitis prediction on human gut MICrobiome

ATOMIC predicts atopic dermatitis using a graph attention network incorporating microbial co-expression networks and genomic data from gut microbiome samples.

A high-throughput microbial glycomics platform for prebiotic development

The paper develops a high-throughput platform to identify gut microbial accessible carbohydrates (MACs) using engineered Bacteroides thetaiotaomicron strains, enabling prebiotic development.

The gut microbiota and sleep in infants: a focus on diurnal rhythmicity patterns

This study examines links between gut microbiota diversity and sleep rhythmicity in infants, finding that higher alpha diversity correlates with more robust sleep rhythms.

Dysbiosis-associated gut bacterium Ruminococcus gnavus varies at the strain level in ability to utilize key mucin component sialic acid

The paper identifies strain-level variation in Ruminococcus gnavus's ability to metabolize sialic acid, revealing diverse metabolic pathways linked to mucin degradation and potential roles in IBD.

Lifestyle transition from rural to urban setting changes the gut bacterial profile in an ethnic community of northeast India

This study examines how urban migration affects the gut microbiome of the Mishing ethnic community in northeast India, finding changes in microbial diversity and functional profiles linked to dietary shifts.

Vancomycin-resistant enterococci colonise the antibiotic-treated intestine by occupying overlapping but distinct nutrient- and metabolite-defined intestinal niches

This study shows that VRE colonize the antibiotic-treated intestine by occupying distinct nutrient-defined niches, using specific nutrients and resisting inhibitory metabolites.

Arylsulfamates inhibit colonic Bacteroidota growth through a sulfatase-independent mechanism

The paper shows arylsulfamates inhibit Bacteroides growth on sulfated glycans via a lipid kinase, not carbohydrate sulfatases, and identifies resistance mechanisms.

Modulating Cardiac-Gut Microbiome Interaction Post-Myocardial Infarction with Engineered Bacteria

This study shows engineered bacteria can improve survival and cardiac function after myocardial infarction by enhancing gut barrier integrity and reducing inflammation.

Microbial Scl1 Activates TGFBR1 receptor kinase signalling to Drive Fibrosis-Inflammation Axis in Alcohol-Associated Liver Disease

The paper identifies Streptococcal Scl1 as a bacterial protein that activates TGFβR1 signaling, driving fibrosis-inflammation in alcohol-associated liver disease through gut microbiota alterations.

Gut Microbiota Succession and Metabolic Pathway Remodeling in the Progression of Type 2 Diabetes Mellitus in Adult Rats

This study examines gut microbiota succession and metabolic pathway changes in adult rats during T2D progression and recovery, showing that interventions like β-tocotrienol and metformin restore microbial diversity and metabolic functions.

Identification and predictive machine learning models construction of gut microbiota associated with lymph node metastasis in colorectal cancer

This study identifies gut microbiota differences associated with lymph node metastasis in CRC and develops predictive machine learning models using these features.

Longitudinal dynamics of ethanol-resistant microbes and sporulation in the human gut

This study examines ethanol-resistant gut bacteria and their sporulation dynamics in humans over six months, finding that resistance correlates with persistence and inter-individual transmission.

Diet, Climatic Conditions, and Sex Affect the Mycobiome of Wild Common Marmosets (Callithrix jacchus)

This study investigates how diet, climate, and sex influence the gut mycobiome of wild common marmosets, finding that environmental factors are more strongly correlated with mycobiome composition than host factors.

Characterizing Bacterial and Archaeal Microbiomes of Urban Long-Tailed Macaques in Singapore

This study characterizes the bacterial and archaeal microbiomes of urban long-tailed macaques in Singapore using 16S amplicon metabarcoding, revealing distinct community structures in oral and gut microbiomes.

Gut Microbial Utilization of the Alternative Sweetener, D-Allulose, via AlsE

This study shows that only a limited number of gut bacteria can metabolize D-allulose via AlsE, suggesting its potential as a low-impact sweetener.

Revisiting the Fungal ITS2 Sequencing Data from the Human Microbiome Project

This paper identifies batch effects and primer mismatches in the Human Microbiome Project's ITS2 sequencing data.

Influence of perinatal ampicillin exposure on maternal fecal microbial and metabolic profiles

This study examines how maternal ampicillin exposure during pregnancy and postpartum affects fecal microbiome and metabolic profiles, linking these changes to increased offspring weight gain.

A three-country analysis of the gut microbiome indicates taxon associations with diet vary by location and strain

The paper analyzes gut microbiome data from three countries to show diet-microbiota associations vary by location and strain.

Strain-specific galactose utilization by commensal E. coli mitigates Salmonella establishment in the gut

The paper shows that specific E. coli strains reduce Salmonella colonization by utilizing galactose, offering insights for microbiota-based infection control strategies.

The Association Between Prevotella copri and Advanced Fibrosis in the Progression of Metabolic Dysfunction-Associated Steatotic Liver Disease

This study identifies Prevotella copri as a driver of MASLD progression by promoting hepatic steatosis and fibrosis through lipid accumulation and impaired intestinal tight junctions.

Gut microbiota dysbiosis induced by brain tumor modulates the efficacy of immunotherapy

This study shows that gut microbiota dysbiosis caused by brain tumors affects immunotherapy efficacy, and tryptophan supplementation or Duncaniella dubosii colonization can restore microbiota and improve survival.

The gut microbiome shapes pharmacology and treatment outcomes for a key anti-inflammatory therapy

This study shows that the gut microbiome affects methotrexate pharmacology in mice and contributes to interindividual variation in drug metabolism and treatment outcomes.

Social stress causes gut dysbiosis in male, female, and aggressor mice

This study examines how chronic social defeat stress affects gut microbiome composition in male, female, and aggressor mice, finding stress-induced dysbiosis with sex-specific correlations.

Comprehensive Survey of Gut Microbiome Associations with Health Conditions in the Human Phenotype Project

This study maps gut microbiome associations with 37 health conditions using the Human Phenotype Project 10K cohort, identifying significant microbial abundance patterns linked to favorable health states.

Gut microbial diversity and inferred capacity to produce short-chain fatty acids are tied to acute stress reactivity in healthy adults

Microbiome variations in osteoarthritis reflect aging and metabolic factors, not the disease

This study analyzes microbiome data from multiple OA cohorts and finds no significant differences between OA patients and controls, attributing microbiome changes to age and BMI instead of OA.

MITScan: Score-Based Genome-Wide Association Analysis of the Microbiome and Host Transcriptome

MITScan performs genome-wide association analysis between microbiome and host transcriptome using zero-inflated negative binomial models, achieving computational efficiency with score tests and permutation methods.