Neuroscience and Neuropharmacology Research

Deletion of Neuroligins from Astrocytes Does Not Detectably Alter Synapse Numbers or Astrocyte Cytoarchitecture by Maturity

This study shows that deleting neuroligins from astrocytes does not affect synapse numbers or astrocyte structure in mice or human neuron co-cultures.

Sex-specific organization and synaptic signaling in prefrontal-hypothalamic circuitry

This study examines sex-specific differences in prefrontal-hypothalamic circuitry in rats, revealing sex differences in neuronal excitability, synaptic connectivity, and stress-activated neurons.

Brain-wide mapping and synaptic localization of C1QL3 using a novel epitope-tagged knock-in mouse

This paper introduces a novel epitope-tagged knock-in mouse model to study C1QL3 localization and function in the brain.

A progressive reduction in basal phosphorylation of glutamate receptors along postweaning development accompanies maturation of hippocampal theta-burst-induced LTP.

This study examines changes in synaptic protein phosphorylation and LTP maturation during postweaning development in rat hippocampal slices.

Adgrd1 deficiency reveals increased hippocampal vulnerability and selective behavioral alterations in mice

This study shows that Adgrd1 deficiency in mice leads to reduced nest-building, decreased exploratory behavior, and increased hippocampal vulnerability through molecular and circuit-level changes.

Cryo-EM Structures of Apo, Agonist- and Antagonist-Bound Heteromeric Kainate Receptors

The paper determines cryo-EM structures of GluK2/GluK5 kainate receptors in apo and ligand-bound states, revealing conformational differences and subtype-specific antagonist effects.

CaMKII T286 autophosphorylation is not propagated at basal Ca2+ levels and is required only for the induction phase of LTP

This study shows that CaMKII T286 autophosphorylation does not propagate at basal Ca2+ levels and is only required during the early phase of LTP induction.

Prolonged developmental programming of somatostatin neurons defines adolescent remodeling of the prelimbic, but not barrel, cortex

The paper compares the developmental maturation of somatostatin-expressing interneurons in the prelimbic and barrel cortices, finding prolonged remodeling in the prelimbic cortex.

Metabotropic Glutamatergic Signaling Adaptively Controls Trans-thalamic Communication

The paper models how mGluRs modulate trans-thalamic communication by altering neuronal dynamics in thalamic and cortical neurons, enhancing sensory information processing and decision-making.

A causal spatial role for apical dendrites in the cortex

The paper demonstrates that apical dendrites in L5 neurons of the mouse visual cortex drive responses to large stimuli rather than suppress them, with extended synaptic inputs.

Astrocytes instructively regulate neuronal translation

This study shows astrocytes regulate neuronal translation through secreted proteins, with implications for neurodegenerative diseases.

Modeling phase separation dynamics of SynGAP and PSD-95 in postsynaptic densities

The paper models phase separation dynamics of SynGAP and PSD-95 in postsynaptic densities using a multicomponent framework to show how association kinetics and interactions affect activity-dependent partitioning.

Stable excitatory-inhibitory synapse balance despite dynamic turnover

The paper develops methods to track excitatory and inhibitory synapses and finds their densities remain steady during maturation despite dynamic turnover.

Dlx5/6 regulate perineuronal net-synapse coupling and stabilize adult cortical Parvalbumin neurons networks

This study shows that Dlx5/6 regulate perineuronal net homeostasis and synaptic organization in adult cortical PV interneurons, linking extracellular matrix stability to network dynamics.

CNIH3 is a molecular signature of slow AMPA receptors

The paper identifies CNIH3 as a molecular marker for slow AMPA receptors in specific hippocampal regions and demonstrates its role in modulating synaptic responses.

Electrophysiological properties and synaptic activity of the mouse hippocampal CA1 neurons during postnatal development

This study examines the postnatal development of electrophysiological properties and synaptic activity in mouse hippocampal CA1 neurons, revealing sex-dependent differences and functional connectivity changes.

A novel, complex-spike burst-dependent form of BCM-like metaplasticity regulates the induction of behavioral timescale synaptic plasticity

The paper investigates how inducing behavioral timescale plasticity (BTSP) at one set of synapses affects plasticity at other synapses, revealing a burst-dependent form of BCM-like metaplasticity.

Geometry-based dynamics of the postsynaptic density explain protein capture by an actin-spine-geometry-dependent synaptic tag

The paper models how actin and spine geometry influence synaptic tagging and capture, showing that PSD remodeling and curvature-mediated PRP recruitment underlie late-phase potentiation.

Functional relevance of mobile and clustered CaV2.1 channels in central synapses

The paper shows that mobile CaV2.1 channels enhance neurotransmitter release reliability at higher frequencies and are inhibited by GABABR activation.

Teneurins Are SPARCL1 Receptors

This study identifies teneurins as SPARCL1 receptors and shows that SPARCL1 enhances synapse formation by binding to teneurins via its follistatin-like domain and activating synapse formation via its Ca2+-binding domain.

Calcium-binding protein expression alone is insufficient to identify and classify GABAergic neurons in macaque cortex

The paper evaluates the use of calcium-binding proteins for classifying GABAergic neurons in macaque cortex and finds that this scheme is invalid due to high non-GABAergic expression and inability to distinguish subpopulations.

Synaptic and Extrasynaptic NMDA Receptors Oppositely Regulate Dendritic Syntaphilin Intrusion in Multiple Sclerosis

The paper investigates how synaptic and extrasynaptic NMDA receptors regulate dendritic Syntaphilin intrusion in inflammatory MS, showing opposing effects on neurodegeneration.

Serotonin Engages Divergent 5-HT Receptor Pathways for Cell Type-Resolved Modulation of Prefrontal Layer 5 Microcircuits

This study investigates how serotonin modulates different cell types in the prefrontal cortex through distinct receptor pathways, revealing cell-type-specific effects on excitability and synaptic transmission.

Striatal cholinergic and dopaminergic driven astrocyte Ca2+ activity is disrupted in Parkinsonian mice

The paper shows that striatal ACh and DA drive astrocyte Ca2+ activity, which is disrupted in Parkinsonian mice, suggesting astrocytes as a therapeutic target.

Astrocyte Store-Released Calcium Modulates Visual Cortex Synapse Development and Circuit Function.

This study shows that astrocytic IP3R2-mediated calcium signaling is essential for glutamatergic synapse maturation and visual circuit function in the mouse visual cortex.

Astrocyte TrkB.T1 deficiency disrupts glutamatergic synaptogenesis and astrocyte-synapse interactions.

This study shows that astrocyte TrkB.T1 is essential for synapse formation and astrocyte-synapse interactions, with loss of TrkB.T1 reducing synapse density and interactions.

Noradrenergic Depletion by DSP-4 Reduces Morphological Complexity of Hippocampal Astrocytes

This study shows that noradrenergic depletion reduces astrocyte morphological complexity in the hippocampus, but β-adrenergic activation does not restore it, suggesting distinct roles for adrenergic signaling in astrocyte structure and density.

An internal PDZ-binding motif in Densin-180 promotes activity-dependent SHANK scaffold remodelling

This study identifies an internal PDZ-binding motif in Densin-180 that promotes SHANK scaffold remodelling through activity-dependent interactions.

Dorso-Ventral and Night-Day Regulation of Extracellular K+ Dynamics in Mouse Hippocampal Astrocytes

The paper investigates how extracellular K+ dynamics in mouse hippocampal astrocytes vary by dorsoventral region and circadian time, revealing regional and temporal differences in K+ buffering capacity.

Evolutionary diversification of lipid logistics shapes synaptic maturation in primates

This study compares human and chimpanzee neurons to show that human neurons have altered lipid metabolism and trafficking, contributing to delayed synaptic maturation during brain development.