Neuroscience and Neuropharmacology Research

Neuronal glutamate transporter EAAT3 regulates hippocampal GABAergic plasticity and reversal learning

This study shows that overexpression of EAAT3 in hippocampal principal neurons impairs LTD and reversal learning, suggesting EAAT3 regulates synaptic plasticity and cognitive flexibility.

Astrocytic chordin-like 1 (Chrdl1) is re-engaged early after ischemic stroke to regulate region-dependent GluA2 levels and neuronal vulnerability

This study identifies Chrdl1's role in regulating neuronal vulnerability after ischemic stroke by stabilizing GluA2 and limiting apoptosis, with region-dependent effects.

Calcium-dependent synaptic proteomics reveals EGFR signaling at active synapses

The paper develops a method to profile synaptic proteomes under physiological conditions and identifies EGFR signaling as a key activity-dependent process at synapses.

Single-particle tracking reveals neuronal activity-dependent shuttling of ARC/ARG3.1 protein between cytoplasmic clusters and the nucleus

This study uses single-particle tracking to show that ARC/ARG3.1 protein shuttles between cytoplasmic clusters and the nucleus in response to synaptic activation.

δ2-Protocadherins organize parallel indirect basal ganglia circuits

This study identifies PCDH17 and PCDH10 as molecular organizers of two distinct indirect basal ganglia circuits that regulate task learning and sensorimotor habituation.

Visual deprivation in adulthood engages presynaptic plasticity of thalamocortical synapses

This study shows that adult mice can exhibit reversible presynaptic plasticity at thalamocortical synapses through visual deprivation and light reintroduction.

Astrocyte-expressed STAT3 regulates glutamate homeostasis and binge ethanol drinking in mice

This study shows that astrocyte-expressed STAT3 maintains glutamate transporter levels and promotes ethanol consumption in male mice.

Dissecting the molecular triggers of early and late long-term potentiation

The paper investigates the molecular mechanisms of early and late long-term potentiation (LTP) by manipulating CaMKII activity and shows that L-LTP can occur without CaMKII activation.

Fascin in Dendritic Protrusions is Required for Synaptic Plasticity

This study shows fascin is present in dendritic spines and regulates synaptic plasticity, challenging previous assumptions about its role in neurons.

Network Topology reveals disrupted AMPA receptor stabilization leads to an impaired LTD in epileptic synapses

The paper identifies a core module of proteins involved in synaptic plasticity in epileptic synapses using network analysis and validates findings with patient transcriptomic data.

NMDA receptor hypofunction on GABAergic interneurons results in input-specific Excitatory/Inhibitory imbalance in pyramidal neurons of medial prefrontal cortex.

This study shows that NMDA receptor hypofunction in GABAergic interneurons causes pathway-specific excitatory/inhibitory imbalance in mPFC pyramidal neurons, affecting only ventral hippocampal inputs.

GluD1 Modulates GluN2B-containing NMDAR Function and Plasticity at Subicular Synapses

This study shows GluD1 is essential for maintaining GluN2B-containing NMDAR function, synaptic plasticity, and memory, with implications for neuropsychiatric disorders.

Dendritic spines implement specific connectivity and support neuronal ensembles in cortical circuits

The paper investigates the structural and functional roles of dendritic spines in cortical circuits, showing they support neuronal ensembles through specific connectivity patterns and synaptic organization.

Adolescent Alcohol Exposure Disrupts Astrocyte-Synaptic Structural And Functional Coupling In The Male Dorsal Hippocampus

This study shows that adolescent alcohol exposure disrupts astrocyte-synaptic coupling in male rats, leading to persistent behavioral impairments that can be partially reversed by astrocyte activation.

Functional and structural characterization of dendritic spine pathology in a mouse model of tauopathy

The paper examines how tauopathy affects dendritic spine function and structure in mice, finding that spines in tau mutants are hypoactive and less tuned compared to controls.

Activity-dependent homeostatic synaptic plasticity widens the temperature range of synaptic transmission

This study shows that homeostatic synaptic plasticity increases AMPA receptor levels in motoneurons during hibernation, enhancing synaptic transmission at cool temperatures and enabling motor behavior restart after inactivity.

Mice with impaired synaptic facilitation exhibit deficits in cognitive flexibility

This study shows that mice lacking Synaptotagmin-7, which is required for synaptic facilitation, have impaired cognitive flexibility in dynamic reward tasks but not in stable ones.

Generation and validation of an Acan-Cre mouse line to selectively label Class-B excitatory neurons of the cerebellar nuclei

The paper generates and validates an Acan-Cre mouse line that selectively labels Class-B excitatory neurons in the cerebellar nuclei for functional studies.

Global Nernstian astrocytic depolarization breaks down during local synaptic input

The paper models astrocyte electrophysiology to show that localized potassium stimuli disrupt Nernstian behavior, with responses governed by conductance ratios and synaptic input specificity.

Single shot low-dose radiation durably and focally increases cortical excitability: a potential therapy for neuronal circuit disorders?

This study shows that low-dose radiation increases cortical excitability in mice, suggesting potential therapeutic use for neuronal circuit disorders.

Decoding spine nanostructure in cultured neurons derived from mouse models of neuropsychiatric disorder reveals a schizophrenia-linked role for Ecrg4

The paper analyzes dendritic spine nanostructure in mouse models of neuropsychiatric disorders, identifying schizophrenia and autism-related spine morphology changes and a role for Ecrg4 in spine dynamics.

Neuronal and astrocytic adaptations in the lateral habenula during withdrawal from chronic ethanol

This study examines neuronal and astrocytic changes in the lateral habenula during ethanol withdrawal in rats, finding reduced neuronal firing and impaired glutamate clearance.

Intrinsic excitability of rat hippocampal granule cells increases along the dorsal-to-ventral axis

This study examines the electrophysiological properties of rat hippocampal granule cells along the dorsoventral axis, finding increased excitability and blade-specific firing rate differences.

C3 and CD47 mediate sensory-motor circuit refinement during spinal cord development

This study identifies C3 and CD47 as dual mechanisms refining spinal sensory-motor circuits by eliminating inappropriate synapses during development.

HSF1 controls transcriptional programs that establish thalamostriatal shaft synaptic architecture and preserve cognitive flexibility

This study identifies HSF1's role in regulating thalamostriatal synapses and cognitive flexibility by controlling transcriptional programs and actin dynamics.

A Polarized Histamine-GABA Core-Rim Architecture within Synaptic Vesicles

The paper identifies a novel core-rim vesicular architecture in GABAergic neurons using ultrastructural analysis, challenging traditional models of transmitter packaging.

Selective impairment of long-term depression in accumbal D1R+ MSNs involves calcium-permeable AMPARs in early Alzheimer's disease

This study identifies a cell-type-specific synaptic mechanism in the nucleus accumbens linking early Aβ accumulation to circuit dysfunction in early Alzheimer's disease.

Disruption of the Homer1 coiled-coiled domain by a novel de novo human HOMER1 variant impairs protein scaffolding, calcium signalling, and synaptogenesis

This paper identifies a novel de novo HOMER1 variant that disrupts protein scaffolding, calcium signaling, and synaptogenesis, contributing to neurodevelopmental disorders.

Ophthalmate tripeptide is a signaling molecule that regulates striatal neurotransmission

This study identifies ophthalmate as a striatal neuromodulator that interacts with dopamine and selectively modulates GABA and glutamate release in motor pathways.

Synaptic input-selective homeostasis safeguards developing cortical neurons toward setpoint activity

The paper shows developing cortical neurons achieve activity setpoints through input-selective synaptic remodeling, overcoming perturbations by selectively strengthening excitation and reducing inhibition.