Neuroscience and Neuropharmacology Research

Sex and experience dependent regulation of synaptic protein turnover

The paper identifies sex and experience-dependent regulation of synaptic protein turnover using SILAM in the hippocampus, finding sex-specific changes in ASD risk genes and experience-induced stabilization of PSD proteins.

Pyramidal neuron synapses in M2 exhibit properties intermediate between prefrontal cortex and M1 synapses

The paper compares synaptic properties of pyramidal neurons in M2 to those in M1 and PFC, finding M2 synapses exhibit intermediate characteristics between the two.

Transregional astrocyte-dependent metaplasticity in the hippocampus

The paper demonstrates transregional astrocyte-dependent metaplasticity in the hippocampus, showing that SO priming inhibits LTP in DG MML synapses via astrocytic TNF signaling and GluN2B receptor activation.

Satellite Glial Cells Drive Homeostatic Synaptic Structural Plasticity in Sympathetic Neurons

This study shows that satellite glial cells regulate synaptic plasticity in sympathetic neurons to maintain homeostasis, with disruptions observed in spontaneously hypertensive rats.

Specialized layer 5 cortical terminals target functional thalamic spines

The paper identifies specialized axo-spinous contacts between layer 5 cortical terminals and thalamic spines, showing their functional role in synaptic transmission and motor learning.

Increased CA3 burst activity in Doc2α and Syt7 knockout mice

This study shows that Doc2 and Syt7 knockout mice exhibit increased CA3 burst activity, suggesting their role in regulating network activity rather than neurotransmitter release.

Presynaptic Terminals Dynamically Modulate Spontaneous Release Frequency During Early Synaptic Plasticity Through and Entropic Force Framework

This study shows how presynaptic terminals modulate spontaneous release frequency during early synaptic plasticity using an entropic force framework, revealing changes in synaptic vesicle pool structure and effects of P301L tau.

Inhibition of delta-1 glutamate receptor current by extracellular protons

This study shows that GluD1R current is inhibited by extracellular protons in mouse serotonin neurons and that GluD1R-deficient mice show impaired CO2-induced behavioral responses.

Region- and layer-specific glutamatergic synapse development in the nascent cortical hierarchy

The paper examines region- and layer-specific glutamatergic synapse maturation in the developing cortex, finding that layers involved in higher-order circuits mature later, particularly in layer 1 during adolescence.

GluN2D-containing NMDA receptors support dentate granule cell excitability, synaptic plasticity, and memory

This study investigates the role of GluN2D-containing NMDA receptors in dentate granule cells, showing their importance in excitability, synaptic plasticity, and spatial memory.

Differential regulation of KCC2 function, trafficking, and degradation by Ca2+-dependent signaling pathways

This study shows that BDNF-TrkB and NMDAR signaling pathways synergistically regulate KCC2 function, trafficking, and degradation through distinct Ca2+-dependent mechanisms.

Astrocytic morphology in the Medial Habenula: sex differences and modulatory factors

This study examines sex-dependent astrocytic morphology in the medial habenula and its modulation by metabolic and inflammatory factors.

Learning Shapes the Energy Cost of Neural Tasks

The paper measures the energy cost of learning-based tasks in mice and finds that post-learning fuel consumption decreases, suggesting energy minimization during learning.

Localized mRNAs and protein synthesis in cortical layer 1

The paper identifies localized mRNAs and proteins in cortical layer 1 synapses, showing specialized transcriptomes and suggesting local translation supports layer-specific functions.

HCN1 channels in GABAergic amygdalar neurons underpin male-biased aggressive behaviors

The paper identifies HCN1 channels in GABAergic amygdalar neurons as a key driver of sex-specific aggression, showing that modulating HCN1 affects aggression levels in male and female mice.

Complementary δ2-protocadherin expression delineates parallel basal ganglia circuits in primates

The paper maps the expression of three δ2-protocadherin genes in primate basal ganglia, showing complementary patterns that align with functional subdivisions and suggest molecular codes for parallel circuits.

Single-cell analysis of sterol-induced Ca2+ signaling in human astrocytes by dynamic mode decomposition

This study uses dynamic mode decomposition to analyze Ca2+ signaling in human astrocytes, showing cholesterol affects Ca2+ dynamics by shifting activity toward oscillatory states or suppressing it.

The role of the glutamate-glutamine cycle in synaptic transmission during ischemia and recovery

This study develops a biophysical model of the glutamate-glutamine cycle during ischemia, showing that synaptic failure is due to EAAT dysfunction and sodium gradient collapse, not glutamate release or glutamine synthetase.

Subcellular Localization of Dopamine D1 and D2 Receptors in the Mouse Hippocampus

The paper uses electron microscopic immunocytochemistry to map the subcellular localization of D1R and D2R in the mouse hippocampus, revealing distinct synaptic and non-synaptic distributions.

Long-range inhibitory control of cholinergic network dynamics in the striatum.

The paper identifies a long-range inhibitory mechanism in striatal circuits that links synchronized cholinergic activity to pause generation during reinforcement learning.

Synaptic activity controls local exposure of an 'eat-me' signal via ANO3-ITPR1 signaling

The paper identifies ANO3-ITPR1 signaling as a caspase-independent mechanism for synaptic phosphatidylserine exposure, which controls synapse pruning during development and neurodegeneration.

Homeostatic regulation of neuronal activity: implications and feasibility of compartment-specific feedback

The paper investigates compartment-specific feedback mechanisms in neurons using computational models to show that local calcium signals can encode separate error signals for homeostatic regulation.

Structural basis for GluA1 AMPA receptor regulation by PRRT1/SynDIG4 in LTP

This study identifies PRRT1/SynDIG4's role in regulating GluA1 AMPA receptors during LTP by sequestering the GluA1 C-terminus via a lipid modification, thereby affecting CaMKII access and LTP induction.

Distinct nanoscale architectures of GABAergic inhibitory synapses predict diverse synaptic output

The paper compares nanoscale organization of GABAergic synapses in somatic and dendritic compartments, finding structural and functional differences that affect inhibitory strength and signaling.

Orientation-invariant morphometry reveals a continuum of dendritic spine forms in layer II pyramidal neurons of the petavoxel human connectome

This paper develops an orientation-invariant morphometry framework to analyze dendritic spines and finds they form a continuum rather than distinct subtypes.

The synaptic vesicle priming protein Munc13 mediates evoked somatodendritic dopamine release

This study investigates the role of Munc13 in evoked somatodendritic dopamine release in dopamine neurons, finding it essential for evoked but not spontaneous release.

SynaptoTagMe: A Toolkit for In Vivo Mapping and Modulating Neurotransmission at Single-Cell Resolution

SynaptoTagMe enables in vivo mapping and modulation of neurotransmission at single-cell resolution in C. elegans by fluorescently labeling and ablating vesicular transporters.

Btbd11 regulates glutamatergic synapse organization in GABAergic inhibitory interneurons

This study identifies Btbd11 as a regulator of glutamatergic synapse organization in GABAergic inhibitory interneurons, showing its role in phase separation and synaptic nanoarchitecture.

CRISPR/Cas9-based knockout screening revealed GSK3β as a regulator of axon initial segment structural plasticity

The paper uses CRISPR/Cas9 knockout screening in chick embryos to identify GSK3β as a regulator of axon initial segment structural plasticity during development.

ESCRT-0 regulates AMPA receptor currents and Ca2+- dependent signaling

This study shows that Hrs, an ESCRT-0 protein, modulates AMPA receptor currents and Ca2+-dependent signaling by sensing and responding to neuronal activity at synapses.