Epilepsy research and treatment

DIFFERENTIAL MEMORY IMPAIRMENT ACROSS RELATIONAL DOMAINS IN TEMPORAL LOBE EPILEPSY

This study assesses memory impairments in temporal lobe epilepsy patients across episodic, semantic, and spatial domains using behavioral tests and statistical analysis.

Altered synaptic connectivity in an in vitro human model of STXBP1 encephalopathy

The paper demonstrates an in vitro human brain model to study STXBP1 haploinsufficiency's effects on synaptic connectivity and cortical development.

A Taxonomy of Seizure Spread Patterns, Speed of Spread, and Associations With Structural Connectivity

The paper develops deep learning algorithms to quantify seizure spread beyond onset zones and finds associations with structural connectivity and surgical outcomes.

The genomic landscape across 474 surgically accessible epileptogenic human brain lesions

This study identifies somatic and germline genetic variants in 474 epileptogenic brain lesions, revealing associations with specific epilepsy subtypes and informing clinical genetic screening.

A hyperthermic seizure unleashes a surge of spreading depolarizations in Scn1a deficient mice

This study shows that hyperthermic seizures in Scn1a deficient mice trigger increased spreading depolarizations, which may contribute to epileptic encephalopathy.

Antisense oligonucleotide therapy for KCNT1 encephalopathy

This study demonstrates that antisense oligonucleotide therapy reduces seizures and improves survival in a KCNT1 mouse model of encephalopathy.

kcna1a mutant zebrafish as a model of episodic ataxia type 1 and epilepsy

This paper uses zebrafish kcna1a-/- mutants to model EA1 and epilepsy, showing ataxia-like behaviors, brain hyperexcitability, and responsiveness to carbamazepine.

Differential regulation of gene expression pathways with dexamethasone and ACTH after early life seizures

The paper investigates how ACTH and dexamethasone affect gene expression pathways in rats after early-life seizures, showing ACTH normalizes expression while Dex does not.

Developmental instability of CA1 pyramidal cells in Dravet Syndrome

This study investigates how loss of Scn1a affects CA1 pyramidal cell development and homeostatic plasticity in a Dravet Syndrome model before seizures occur.

Local neuronal excitation and global inhibition during epileptic fast ripples in humans.

The paper characterizes neuronal responses to fast ripples in human epilepsy, showing local excitation and global inhibition across brain networks.

Low-cost platform for multi-animal chronic local field potential video monitoring with graphical user interface (GUI) for seizure detection and behavioral scoring

The paper presents a low-cost platform for multi-animal chronic seizure monitoring with real-time synchronization of video and local field potential data, along with a user-friendly GUI for seizure detection and behavioral scoring.

Lateralized phenotypic differences after intrahippocampal kainic acid injection in female mice

This study shows that injecting kainic acid into the left or right hippocampus of female mice leads to different reproductive endocrine and cellular outcomes, despite similar estrous cycle disruptions.

Evaluating the efficacy of prototype antiseizure drugs using a preclinical pharmacokinetic approach

The paper evaluates the pharmacokinetics of antiseizure drugs in rodent models to assess their efficacy and duration of action.

A personalizable autonomous neural mass model of epileptic seizures

This paper introduces a laminar neural mass model that realistically reproduces SEEG recordings during epileptic seizures and demonstrates its ability to capture key electrophysiological features.

Magnetogenetic closed-loop reduction of seizure activity in a rat model of epilepsy

This study demonstrates that magnetogenetics using the EPG gene in inhibitory interneurons can reduce seizure frequency and delay onset in a rat epilepsy model.

De novo missense variants in SLC32A1 cause a neurodevelopmental disorder with epilepsy due to impaired GABAergic neurotransmission

This study identifies de novo missense variants in SLC32A1 as a cause of a neurodevelopmental disorder with epilepsy, showing they impair GABAergic neurotransmission through two mechanisms.

Galanin Analogs Prevent Seizure-Induced Respiratory Arrest

This study shows that galanin agonists prevent seizure-induced respiratory arrest in mice, suggesting they could be a potential therapy for SUDEP.

Seizures, behavioral deficits and adverse drug responses in two new genetic mouse models of HCN1 epileptic encephalopathy

This study presents two genetic mouse models of HCN1 epileptic encephalopathy, showing seizure susceptibility and adverse drug responses, highlighting the need for tailored therapies.

Localized network hyperconnectivity leads to hyperexcitability after injury

The paper shows that hyperconnected local networks formed by homeostatic rewiring after brain injury lead to hyperexcitability and seizure-like activity.

Elevated photic response is followed by a rapid decay and depressed state in ictogenic networks

The paper compares zebrafish epilepsy models to identify conserved and divergent features of neural and behavioral activity, finding that photic stimulation reliably evokes seizures with a characteristic depressed state.

Focal seizures are organized by feedback between neural activity and ion concentration changes

The paper develops a biophysically realistic computational model to simulate focal seizures, showing how ionic dynamics drive seizure initiation and termination patterns observed in human and animal data.

On the Mental Status of Stargazer Mice

This study examines the neurobehavioral phenotype of Stargazer mutant mice, revealing a syndrome with ataxia, hyperactivity, and behavioral abnormalities linked to Cacng2 disruptions.

Transcriptome profiling implicates a role for Wnt signaling during epileptogenesis in a mouse model of temporal lobe epilepsy

This study identifies dynamic transcriptional changes in the hippocampal dentate gyrus of a mouse model of temporal lobe epilepsy, highlighting dysregulation of the Wnt signaling pathway during the latent period of epileptogenesis.

Longitudinal structural change of gray matter before and after hemispherotomy

This study examines GMV changes and behavioral outcomes in pediatric patients after hemispherotomy, finding that contralateral cerebellum GMV decreases correlate with behavioral improvement in right hemispherotomy patients.

Cortical Parvalbumin-positive Interneuron Development and Function are Altered in the APC Conditional Knockout Mouse Model of Infantile Spasm Syndrome

This study shows that APC conditional knockout mice exhibit altered parvalbumin-positive interneuron development and inhibitory synaptic dysfunction, contributing to ISS-like phenotypes.

The SCN1A Philadelphia variant - a gain-of-function mutation causing an early-onset epileptic encephalopathy

This paper identifies and characterizes the SCN1A p.R1636Q gain-of-function variant, showing it causes early-onset epileptic encephalopathy with distinct clinical and electrophysiological features.

The Interictal Suppression Hypothesis in Focal Epilepsy: Electrographic and Structural Evaluation

The paper tests the interictal suppression hypothesis in focal epilepsy using electrographic and structural data to identify seizure onset zones and develop a classification model with high accuracy.

Acute inhibition of the STA3 signaling pathway during epileptogenesis prevent GABAergic cells loss and imprinting of epileptic state: an in-vitro proof

This study shows that inhibiting STAT3 signaling during epileptogenesis prevents epileptic activity, cell loss, and inflammatory glial states in an in vitro model.

Robust, long-term video EEG monitoring in a porcine model of post-traumatic epilepsy.

This paper describes a long-term video EEG monitoring system in a porcine model of post-traumatic epilepsy, demonstrating its utility for studying epileptogenesis over 14 months.

Characterizing the diversity of L2/3 human neocortical neurons in epilepsy

This study characterizes the diversity of L2/3 human neocortical pyramidal neurons in epileptic foci, comparing MCD and non-MCD cases and examining the effects of 4-AP on their intrinsic properties.