Epilepsy research and treatment

G protein-coupled potassium channels implicated in mouse and cellular models of GNB1 Encephalopathy

This study identifies GNB1 mutations causing neurodevelopmental disorder and shows ethosuximide effectively treats symptoms in mouse and cellular models.

Early Ictal Recruitment of Midline Thalamus in Mesial Temporal Lobe Epilepsy

The paper investigates the role of midline thalamus in mesial temporal lobe seizures, finding it is recruited early in seizure initiation and propagation.

To: Editor-in-ChiefA theory of neocortical seizure spread: Insights from statistical physics

The paper develops a mathematical model of seizure spread using statistical physics methods to explain how macroscopic seizure properties emerge from microscopic neuronal clusters.

Critical slowing as a biomarker for seizure susceptibility

This study identifies critical slowing as a biomarker for seizure susceptibility using long-term iEEG recordings from epilepsy patients.

Effects of single cage housing on stress, cognitive and seizure parameters in the rat and mouse pilocarpine models of epilepsy

This study examines the effects of individual housing on stress, cognitive, and seizure parameters in rat and mouse epilepsy models, finding increased stress and seizures in singly housed animals.

Pyridox(am)ine 5’-phosphate oxidase deficiency induces seizures in Drosophila melanogaster

This study establishes Drosophila models of PNPO deficiency, showing seizures and lethality linked to low PLP levels, and demonstrates functional conservation between human and fly PNPO.

Dysmorphic neuron density underlies intrinsic epileptogenicity of the centre of cortical tubers

This study shows that resecting only the center of cortical tubers in TSC patients eliminates seizures without functional deficits, as the center has higher dysmorphic neuron density.

Seizures cause sustained microvascular constriction associated with astrocytic and vascular smooth muscle Ca2+ recruitment

The paper shows seizures cause prolonged microvascular constriction in mice, linked to astrocytic and vascular smooth muscle Ca2+ changes, and COX-2 dependency.

Diagnostic Yield And Treatment Impact Of Targeted Exome Sequencing In Early-Onset Epilepsy

This study evaluates the diagnostic yield and treatment impact of targeted whole-exome sequencing in early-onset epilepsy, finding a 34% diagnostic rate with faster diagnosis and cost savings when used early.

Early detonation by sprouted mossy fibers enables aberrant dentate network activity

The paper shows that sprouted mossy fibers in temporal lobe epilepsy can initiate recurrent network activity despite short-term depression due to high initial glutamate release and lack of adenosine inhibition.

Targeted gene sequencing in 6994 individuals with neurodevelopmental disorder with epilepsy

The paper analyzes genetic variants in 6,994 individuals with neurodevelopmental disorder with epilepsy to assess diagnostic yield and identify ultra-rare variants in associated genes.

Potentiating α2 subunit containing perisomatic GABAA receptors protects against seizures in a mouse model of Dravet Syndrome

The paper shows that targeting α2 subunit-containing GABAA receptors with AZD7325 reduces seizures in Dravet syndrome mice without sedation.

Modulation of electrocorticographic seizure features predicts response to closed-loop brain stimulation

The paper identifies indirect electrophysiological effects of RNS stimulation that predict improved seizure control in epilepsy patients.

KCC2 overexpression prevents the paradoxical seizure-promoting action of somatic inhibition

This study shows that overexpressing KCC2 in principal neurons prevents PV+ interneurons from promoting seizures during seizure onset.

Prevalence of Depression among Epileptic Patients and its Association with Drug Therapy: A Systematic Review and Meta-Analysis.

This study conducts a systematic review and meta-analysis to determine the prevalence of depression among epileptic patients in sub-Saharan Africa and its association with drug therapy.

A Role for Gαz in regulating seizure susceptibility

This study investigates the role of Gαz in seizure susceptibility by analyzing Gz-null mice and finding increased seizure susceptibility and electrographic seizure activity.

Controlling seizure propagation in large-scale brain networks

This paper develops a seizure control strategy using patient-specific brain network models to predict and modulate seizure propagation patterns in epilepsy patients.

Evaluating Invasive EEG Implantations in Medically Refractory Epilepsy with Functional Scalp EEG Recordings and Structural Imaging Data

This paper introduces a method combining scalp EEG and imaging data to improve EZ localization in MRE patients, showing better overlap with successful implantations.

BRAFV600E Expression in Mouse Neuroglial Progenitors Increase Neuronal Excitability, Cause Appearance of Balloon-like cells, Neuronal Mislocalization, and Inflammatory Immune response.

This study investigates how BRAFV600E mutation affects neuronal excitability and histopathological features in mouse cortical slices, showing increased excitability and balloon-like cell formation.

Region-specific differences and areal interactions underlying transitions in epileptiform activity

The paper shows that epileptiform activity transitions in vitro arise from shifts in ictal sources, with hippocampal activity entraining other cortical areas through non-synaptic mechanisms.

The mGlu7 receptor provides protective effects against epileptogenesis and epileptic seizures

This study investigates the protective effects of mGlu7 receptor activation against epileptogenesis and seizures using a drug in two mouse models.

Human and Rodent Temporal Lobe Epilepsy is Characterized by Changes in O-GlcNAc Homeostasis that can be Reversed to Dampen Epileptiform Activity

This study shows that O-GlcNAc homeostasis is disrupted in TLE and that inhibiting OGA can reverse these changes and reduce seizures.

High interictal connectivity within the resection zone is associated with favorable post-surgical outcomes in focal epilepsy patients

Chemicogenetic recruitment of specific interneurons suppresses seizure activity

This study uses chemicogenetic techniques to selectively enhance inhibitory interneurons in the hippocampus, finding that PV interneurons most effectively suppress seizure activity in vitro and in vivo.

Adaptation and inhibition control pathological synchronization in a model of focal epileptic seizure

This paper develops a neural mass model incorporating spike-frequency adaptation to study seizure dynamics, showing adaptation and inhibition control pathological synchronization in epilepsy.

Opposing effects of prostaglandin receptor EP2 signaling in mouse immune cells and neurons after status epilepticus

The paper identifies opposing effects of EP2 receptor signaling in immune cells and neurons after status epilepticus, showing immune cell EP2 is harmful while neuronal EP2 is protective.

Asynchronous suppression of visual cortex during absence seizures

The paper examines neuronal activity in the visual cortex of stargazer mice during absence seizures, finding asynchronous suppression of most neurons.

Role of inhibitory control in modulating spread of focal ictal activity

The paper investigates how inhibitory control affects the spread of focal ictal activity in a rodent model, showing that localized inhibition defects can lead to both classical and epileptic network propagation.

Levetiracetam and Rufinamide are effective at supressing spike and wave seizure activity in an in vitro model of absence epilepsy.

This study evaluates the effectiveness of Levetiracetam and Rufinamide in reducing spike-and-wave seizure activity in an in vitro absence epilepsy model.

Degenerate time-dependent network dynamics anticipate seizures in human epileptic brain

The paper identifies a pre-seizure critical phase with reduced network variability and global connectivity reduction in human epileptic brain recordings.