Chronic Obstructive Pulmonary Disease (COPD) Research

HHIP protein interactions in lung cells provide insight into COPD pathogenesis

The paper identifies HHIP protein interactions in lung cells, revealing new connections to COPD GWAS genes and providing insights into COPD pathogenesis.

Cigarette smoke induces PPP1R15A via oxidative stress to modulate inflammatory cytokine production by bronchial epithelial cells

This study shows cigarette smoke induces PPP1R15A through oxidative stress, which reduces pro-inflammatory cytokine production in bronchial epithelial cells.

Repeated cigarette smoke exposure attenuates the proliferation rate of primary human lung fibroblasts in vitro

This study shows that repeated cigarette smoke exposure reduces the proliferation of human lung fibroblasts more than single exposure, with early exposure offering some protection against later exposures.

KF4 anti-CELA1 Antibody and Purified α1-Antitrypsin Have Similar but Not Additive Efficacy in Preventing Emphysema in Murine α1-Antitrypsin Deficiency

This study evaluates KF4 anti-CELA1 antibody and purified α1-antitrypsin in preventing emphysema in AAT-deficient mice, finding similar efficacy with no additive benefit when combined.

Proteomic Networks and Related Genetic Variants Associated with Smoking and Chronic Obstructive Pulmonary Disease

The paper identifies proteomic networks and genetic variants associated with smoking and COPD phenotypes using multi-ethnic proteomic data and network-based GWAS.

The lung extracellular matrix protein landscape in severe early-onset and moderate chronic obstructive pulmonary disease.

The paper compares ECM protein expression in severe-early onset and moderate COPD to controls, identifying ECM signatures linked to disease severity and subtypes.

Exploring Inflammatory Dysregulation in Alveolar Macrophages: Implications for Novel Therapeutic Targets in Chronic Obstructive Pulmonary Disease

This study identifies novel therapeutic targets for COPD through meta-analysis of gene expression data and drug repurposing of FDA-approved drugs targeting CXCL9.

Identification of key genes and biological pathways in chronic obstructive pulmonary disease using bioinformatics and next generation sequencing data analysis

This study identifies differentially expressed genes and hub genes in COPD using NGS data and bioinformatics analysis, suggesting potential biomarkers and molecular targets.

Heterogeneity analysis of acute exacerbations of chronic obstructive pulmonary disease and a deep learning framework with weak supervision and privacy protection

The paper identifies heterogeneity in acute exacerbations of COPD using wearable data and develops a deep learning framework with weak supervision and privacy protection for early detection.

Genetic Regulators of Sputum Mucin Concentration and Their Associations with COPD Phenotypes

This study identifies genetic variants associated with sputum mucin concentrations and links one variant to COPD phenotypes like chronic bronchitis and acute exacerbations.

Somatic mutations in chronic lung disease are associated with reduced lung function

The paper finds that somatic mutations in diseased lung tissue correlate with reduced lung function and cell type proportions in COPD and IPF.

Multi-ancestry genome-wide association study improves resolution of genes, pathways and pleiotropy for lung function and chronic obstructive pulmonary disease

This study performs a multi-ancestry GWAS on lung function and COPD, identifying 559 genes and 29 pathways, and showing genetic risk scores are associated with COPD across ancestries.

De novo discovery of traits co-occurring with chronic obstructive pulmonary disease

This study identifies genetic variants and genes associated with COPD and co-occurring traits by integrating multi-omics data and gene regulatory networks.

Leveraging deep-learning on raw spirograms to improve genetic understanding and risk scoring of COPD despite noisy labels

This paper trains a deep neural network on noisy COPD labels to predict COPD status from spirograms, improving genetic discovery by identifying new loci and replicating existing ones.

Proteomic network analysis of bronchoalveolar lavage fluid in ex-smokers to discover implicated protein targets and novel drug treatments for chronic obstructive pulmonary disease

The paper identifies differentially expressed proteins in COPD patients' bronchoalveolar lavage fluid and uses network analysis to find potential drug targets and repurposable therapies.

Genetic associations and architecture of asthma-chronic obstructive pulmonary disease overlap

This study identifies eight novel genetic signals associated with asthma-COPD overlap through a genome-wide association analysis involving multiple cohorts.

HIF-1α Contributes to the Progression of Chronic Obstructive Pulmonary Disease

This study investigates the role of HIF-1 in COPD progression using digoxin as an inhibitor, showing its protective effects against inflammation and EMT through the HIF-1/TGF-β1/Smad3 pathway.

Smoking Interaction with a Polygenic Risk Score for Reduced Lung Function

This study investigates whether smoking modifies the effect of a polygenic risk score on reduced lung function, finding significant gene-by-smoking interactions in FEV1/FVC.

Transcription factors involved in stem cell maintenance are downstream of Slug/Snail2 and repressed by TGF-β in bronchial basal stem/progenitor cells from COPD

Integrative Omics Reveal Novel Protein Targets For Chronic Obstructive Pulmonary Disease Biomarker Discovery

The paper identifies proteins associated with lung function and COPD risk using integrative omics and Mendelian Randomization, finding 37 proteins with causal associations.

Characterization of a Disease-Associated NPNT Functional Splicing Genetic Variant in Human Lung Tissue via Long-Read Sequencing

The paper identifies a genetic variant in NPNT associated with COPD risk and lung function through splicing analysis using long-read sequencing.

The protective effect of club cell secretory protein (CC-16) on COPD risk and progression: a Mendelian randomisation study

This study uses Mendelian randomisation to show that higher serum CC-16 levels protect against COPD risk and progression, with genetic variants linked to CC-16 expression in lung tissue.

Peripheral blood microbial signatures in COPD

This study identifies peripheral blood microbial signatures associated with COPD and exacerbation phenotypes in smokers.

Alterations of multiple alveolar macrophage states in chronic obstructive pulmonary disease

This study uses single-cell RNA-seq and computational methods to analyze macrophage states in COPD patients, revealing transcriptional changes and metabolic shifts associated with the disease.

Novel Type 2-high gene clusters associated with corticosteroid sensitivity in COPD

The paper identifies a corticosteroid-sensitive gene cluster in COPD patients using asthma-derived transcriptomic signatures and links it to mast cell numbers and lung function improvement.

PulmonDB: a curated lung disease gene expression database

PulmonDB provides a curated database and R library for exploring gene expression in COPD and IPF, enabling differential expression analysis and hypothesis generation.

Widespread Sexual Dimorphism in the Transcriptome of Human Airway Epithelium in Response to Smoking

The paper identifies sex-specific transcriptomic responses to smoking in human airway epithelium, revealing sexually dimorphic gene modules associated with autophagy and immune response pathways.

Meta-analysis of Gene Expression Microarray Datasets in Chronic Obstructive Pulmonary Disease

This study performs a meta-analysis of gene expression microarray datasets to identify differentially expressed genes in COPD, finding 304 genes and a logistic regression model with 84% accuracy for disease prediction.

A Clinical Phenotyping Algorithm to Identify Cases of Chronic Obstructive Pulmonary Disease in Electronic Health Records

This paper develops a clinical phenotyping algorithm to identify COPD cases in EHRs using ICD codes, achieving high sensitivity and negative predictive value.

Opioids for breathlessness: Psychological and neural factors influencing response variability

This study investigates how psychological and neural factors influence variability in opioid response to breathlessness, finding negative affect and brain activity correlate with reduced efficacy.