Microtubule and mitosis dynamics

Septins regulate cytokinesis and multicellular development in the closest living relatives of animals

This study shows that septins regulate cytokinesis and multicellular development in Salpingoeca rosetta, a choanoflagellate closely related to animals.

A Distinct Interphase Microtubule State Marks Host Cell Permissiveness to Chlamydia pneumoniae Entry

CYB-4/CDK-1 coordinates timing of meiotic entry, chromosome morphogenesis and oocyte maturation in C. elegans

This study identifies CYB-4 as a meiosis-specific cyclin that coordinates meiotic entry, chromosome structure, and oocyte maturation with CDK-1 in C. elegans.

Auxin-inducible degron-mediated protein depletion in Diplonema papillatum

This study introduces an auxin-inducible degron system in Diplonema papillatum to enable conditional protein depletion and assesses its effects on key cellular processes.

Patronin condensation integrates recognition, protection and organization of microtubule minus ends

This study shows that Drosophila Patronin forms condensates at microtubule minus ends through a prion-like domain, integrating recognition, protection, and organization of these ends.

Tracing the dynamic recruitment trajectory of Optineurin between the centrosome and other macromolecular assemblies, signifying its role in cell cycle progression

This study tracks Optineurin's movement between the centrosome and cytokinetic structures during cell division, revealing its microtubule-dependent trafficking and role in cell cycle progression.

Higher frequency of homologous chromosome pairing in adult endothelial cells as compared to neonatal endothelial cells

The paper compares homologous chromosome pairing in adult and neonatal endothelial cells, finding higher pairing frequency in adults.

Differential contributions of β tubulin isotypes to acentrosomal oocyte meiosis in C. elegans

The paper investigates how β-tubulin isotypes TBB-1 and TBB-2 contribute to acentrosomal spindle bipolarity and function in C. elegans oocytes.

A possible role for the kinetochore COMA complex in sensing the damage in stn1-sz2, a mutant of the Cdc13-Stn1-Ten1 telomeric complex

The paper investigates how the stn1-sz2 mutant of the CST complex causes mitotic-spindle-damage and identifies the COMA complex's role in sensing this damage through kinetochore interactions.

Taccalonolide AJ uncouples tubulin GTP hydrolysis from microtubule depolymerization

This study shows that taccalonolide AJ stabilizes microtubules through a mechanism distinct from paclitaxel, promoting a compacted, post-GTP hydrolysis state that resists depolymerization.

Dendritic Morphology Constrains Microtubule Dynamics and Organization

This study shows that dendritic morphology constrains microtubule dynamics and organization in Drosophila neurons, challenging the traditional view that microtubules shape cell morphology.

Multiple evolutionary routes to cytoskeletal arborization revealed by the rhizarian amoeba Filoreta ramosa

This study investigates cytoskeletal arborization in the rhizarian amoeba Filoreta ramosa, revealing multiple evolutionary routes to similar branched cellular architectures.

Therapeutic Stress-induced Activation of PGCC Life Cycle Drives the Resistance Acquisition and Structured Tissue Differentiation

This study tracks how therapeutic stress activates a PGCC life cycle, leading to resistance and tissue differentiation in cancer cells.

Targeting REV7 exposes a mitotic vulnerability in colorectal cancer cells

This study shows that targeting REV7 with C10 sensitizes colorectal cancer cells to microtubule disruption, revealing a mitotic vulnerability.

Greatwall Kinase regulates Acute Myeloid Leukaemia Cell Division through a Non-Canonical Mechanism

This study shows Greatwall kinase regulates AML cell division through a non-canonical pathway distinct from its role in solid tumors.

Excess p50 induces Arp1-dependent dynactin clusters containing the assembly factor VezA

The paper shows that excess p50 induces Arp1-dependent dynactin clusters containing VezA in A. nidulans, revealing a role for p50-Arp1 interactions in trapping VezA.

FXR proteins and BICD2 cooperate to promote dynein-mediated RNP transport and stress granule assembly

This study shows that FXR proteins and BICD2 work together to activate dynein for RNP transport and stress granule formation, revealing separable steps in dynein-mediated transport.

A meiotic B-type cyclin selectively drives mitotic progression and fidelity in cancer cells

This study shows cyclin B3-CDK1/2 drives mitotic progression and fidelity in cancer cells, with overexpression accelerating mitosis and depletion disrupting it in multiple cancer models.

Tubulin C-terminal tails are pH sensors that regulate microtubule function

The paper investigates how tubulin C-terminal tails respond to pH changes and shows their role in regulating microtubule interactions through protonation of glutamate residues.

Spatial separation provides the force-coupling mechanism for the spindle assembly checkpoint

This study shows that spatial separation of Aurora B from the outer kinetochore regulates MPS1 recruitment and SAC signaling during mitosis.

Dynamic microtubule-end structure governs multivalent kinetochore coupling by the Dam1c ring

This study shows that the Dam1 complex ring stabilizes kinetochore-microtubule attachments through a dynamic, disordered protein complex and microtubule structure, explaining force transduction and attachment stability.

Molecular and cellular characterization of the interaction between the Rho GAP RGA-3/4 and F-actin

This study investigates how RGA-3/4 regulates F-actin structure in vivo and in vitro, showing it directly binds and bundles F-actin, providing insights into its role in cortical excitability and cytokinesis.

A multivalent docking platform and Rcn1-mediated inhibition control the extent of calcineurin recruitment to the cell division site for the dephosphorylation of multiple cytokinetic proteins

This study identifies how calcineurin (CN) is recruited to the cytokinetic ring in fission yeast and shows that Rcn1 inhibits CN to regulate cytokinesis.

Whole genome duplication through mitotic slippage causes nuclear instability

The paper investigates how different routes to whole-genome duplication (WGD) affect nuclear stability, finding that mitotic slippage uniquely causes nuclear instability.

Resource limitation rewires chromosome instability and ploidy evolution across in vitro and in vivo cancer models

This study models how resource limitations and chromosomal instability influence ploidy evolution in cancer cells across in vitro and in vivo settings.

An internal scaffold supports microtubule architectural diversity in Xenopus spermatids

The paper identifies an internal scaffold in Xenopus spermatid microtubules that supports structural diversity and nuclear reshaping during spermiogenesis.

Cnidarian oocytes reveal conserved actin-driven mechanisms of female meiosis

The paper identifies conserved actin-driven mechanisms in jellyfish oocytes that facilitate meiosis, suggesting ancient origins in metazoans.

Distinct Tubulin C-Terminal Tails Control the Efficiency of a Microtubule Severing Machine

This study investigates how different tubulin CTT isotypes influence katanin structure and dynamics, revealing that inhibitory CTTs enhance pore narrowing and flexibility, while non-inhibitory CTTs disrupt coordination.

Uncoupling microtubule lifetime, stability and post-translational modifications.

The paper measures microtubule turnover and PTMs in mouse cells, finding that PTMs do not accumulate with age or correlate with stability.

Meiotic kinetochore reconstitution identifies chromosome segregation factors

This study reconstitutes vertebrate meiotic kinetochores to identify conserved factors essential for chromosome segregation in mammalian oocytes.