Neurogenesis and neuroplasticity mechanisms

This study shows THAP1 regulates oligodendrocyte maturation by controlling lysosomal degradation of glycosaminoglycans in OPCs.

The paper uses single-cell RNA sequencing to identify two distinct progenitor populations in zebrafish spinal cord pMN cells, one producing neurons and the other producing oligodendrocytes, marked by gsx2 expression.

This study identifies transcriptional and chromatin changes during astrocyte maturation in vivo and in culture, showing that extrinsic signals regulate intrinsic transcription factors to drive maturation.

The paper identifies Sox9 as a key regulator of neurogenic behavior in radial glial progenitors, showing its role in maintaining stem cell identity and generating upper-layer neurons.

The paper uses single-cell and single nucleus sequencing to identify two distinct adult neurogenic lineages in the mouse V-SVZ, marked by specific gene expression patterns.

The paper investigates the synaptic connectivity of Lpar1-EGFP subplate neurons in mouse somatosensory cortex, identifying two subtypes with distinct axonal projections and input patterns.

The paper identifies a TCF-4-dependent transcription factor network regulating commissure development in mice using scRNA-seq and bioinformatic analysis.

This study identifies Grem1 as a marker for neuroprogenitors generating cortical glutamatergic neurons and shows that its deletion causes cortical and behavioral defects in mice.

The paper identifies a unique molecular signature of Olig2-expressing astrocytes through transcriptome profiling and differential gene expression analysis.

This study shows that loss of Lhx2 in cortical progenitors leads to premature thalamocortical innervation due to altered subplate neuron development.

This study shows that increasing adult-born neurons improves memory precision and indexing, contributing to cognitive flexibility.

This study shows that increased neurogenesis in rats leads to forgetting of multiple types of hippocampus-dependent memories across different tasks.

This study uses single-cell RNAseq to analyze progenitor and neuronal diversity in the developing mouse cerebral cortex, revealing how spatial and temporal factors contribute to neuronal fate acquisition.

This study reveals that individual interfascicular oligodendrocytes selectively myelinate distant axons with consistent thicknesses and that adjacent sheaths show correlated thicknesses.

This paper develops a theoretical model explaining how adult-born dentate granule cells integrate into neural networks and support pattern separation through changes in GABAergic input.

The paper identifies multiple gliogenic domains in the adult V-SVZ by studying PDGFRβ-expressing NSCs and their release from quiescence.

This study shows that Fmrp regulates oligodendrocyte lineage cell specification and differentiation in zebrafish embryos, leading to increased OPCs and reduced OL differentiation in fmr1 mutants.

This study investigates how birth timing influences the wiring and physiological response properties of cerebellar granule cells by comparing early- and late-born cells using viral tracing and in vivo imaging.

The paper shows that endogenous neural progenitors modulate microglia and reduce demyelination in the cuprizone model by promoting phagocytosis of myelin debris.

The paper shows that Notch signaling regulates the fate of cerebellar progenitors to generate both excitatory and inhibitory neurons.

This study identifies BMPR-2 as a key regulator of dendrite stabilization in mitral cells through interactions with LIMK and neuronal activity.

This study identifies a signaling cascade involving WNT-PROX1-CCND1-ATOH1 that regulates cerebellar granule cell progenitor proliferation and immaturity.

This study identifies NFI factors as repressors of tanycyte-derived neurogenesis and shows their disruption promotes proliferation and neurogenesis in the hypothalamus.

This study shows that blocking hippocampal neurogenesis in rats reduces activation of the ventral dentate gyrus and causes aversion to delayed rewards.

The paper identifies miR-541 as an Eutherian-specific microRNA that regulates Satb2 translation during cortical development, revealing its role in timing neuronal identity.

This study shows that Arid1a is essential for subplate neuron function and cortical connectivity, with its loss causing axon miswiring and corpus callosum agenesis.

The paper uses modeling and experimental data to show that a signal recruits ependymal cells within a specific spatiotemporal window during axolotl spinal cord regeneration.

This study uses a viral labelling approach to analyze changes in transitional oligodendrocyte morphology under activity-dependent conditions and injury.

This study characterizes the development of the entorhinal cortex in pigs and mice, revealing a parallel lamination pattern during neurogenesis that differs from neocortical lamination.