Neurogenesis and neuroplasticity mechanisms

The paper shows that reduced ventral oligodendrocyte precursor cells lead to increased dorsal OPCs with abnormal morphology and function in the spinal cord.

This study shows that motor learning after partial remyelination enhances remyelination by increasing oligodendrogenesis and myelin sheath generation.

This study shows ephrin-B2 regulates the timing and number of neuronal production in the developing neocortex through juxtacrine signaling on neural progenitors.

This paper develops vascularized human cortical organoids that model cortical development and show synaptic activity and integration potential in vivo.

The paper models the progression of human neural stem cells in vitro, showing they transition through organizer states before committing to cortical excitatory or inhibitory neuronal fates.

This study shows human glial progenitor cells can remyelinate both congenitally and acutely demyelinated adult CNS regions, extending lifespan and restoring function in mouse models.

The paper investigates the dynamics of adult neural stem cells in zebrafish, showing a hierarchical organization with reservoir and operational stem cells and an upstream progenitor population supporting long-term neurogenesis.

This study shows that brain-synthesized estrogens affect cortical neuron migration differently in male and female mice through Cyp19a1 knockdown.

This study shows that Nwd1 regulates purinosome formation in neural stem/progenitor cells, affecting neuronal differentiation and migration in the developing cerebral cortex.

The paper profiles miRNAs in mouse cortical progenitors and neurons, identifying miR-486-5p as a novel regulator of neurogenesis.

The paper identifies a conserved enhancer module regulating id1 expression in zebrafish neural stem cells, showing BMP signaling controls NSC quiescence and proliferation.

This study shows that transferring BCG-induced T lymphocytes into immune-deficient mice increases hippocampal cell proliferation and reduces anxiety-like behavior.

This study shows Sox9 regulates basal progenitor proliferation and gliogenesis in the developing neocortex through ECM induction and integrin signaling.

The paper shows that Crumbs2 (CRB2) mediates dorsal collapse in the spinal cord by promoting cell delamination and ventricular layer remodelling.

This paper characterizes Zswim5 expression in mouse cortical interneuron progenitor domains and migration pathways, showing its correlation with postmitotic cells and potential role in neurogenesis and migration.

This study shows that microglia are necessary for the functional development of adult-born neurons in the olfactory bulb by promoting excitatory synapse formation.

The paper characterizes cell types and circuit organization within neocortical radial clones using single-cell RNA-sequencing and electrophysiological recordings, finding that clones contain diverse cell types and exhibit specific connectivity patterns.

The paper shows that Gsx2 and Ascl1 physically interact in the mouse lateral ganglionic eminence, inhibiting Ascl1-driven neurogenesis and promoting progenitor expansion.

The paper shows that recombination of one floxed gene does not reliably predict recombination of another floxed gene in single neural stem cells, suggesting potential for false conclusions in cell autonomous studies.

The paper identifies two functionally distinct subgroups of OPCs in zebrafish spinal cord, showing activity-dependent proliferation and differentiation.

This study characterizes neurogenic niches in the telencephalon of juvenile and adult sharks using immunohistochemical markers, identifying distinct cell subtypes involved in neurogenesis.

The paper investigates the effect of arginase inhibition with norvaline on adult neurogenesis in Alzheimer's disease mice, finding increased neuronal survival and molecular markers of maturation.

The paper compares in vitro and in vivo transcriptomic and proteomic profiles of adult hippocampal NSPCs, finding discrepancies in secreted protein abundance and gene expression.

This study identifies Foxp1's role in maintaining apical radial glia identity and promoting deep layer cortical neuron production during neocortex development.

The paper shows that in juvenile killifish, accelerated brain growth is driven by a second type of progenitors rather than increased radial glia activity.

This study shows that Cyfip1 is critical for maintaining the adult subventricular zone niche by regulating B1 cell proliferation and adherens junction proteins.

This study examines how fluoxetine affects behavior and adult hippocampal neurogenesis in female mice across the estrous cycle, finding phase-specific effects.

This study shows TCF7L2 regulates thalamic neuron differentiation and electrophysiological features by controlling gene expression and cell migration.

This study shows PRDM16 regulates MGE progenitor proliferation and GABAergic interneuron production by repressing differentiation genes.