Cerebrospinal fluid and hydrocephalus

Local B cell maturation and mast cell regulation of choroid plexus function in early life.

The paper uses single-cell sequencing to study immune cell development in the choroid plexus, showing B cell maturation and mast cell regulation impact brain development.

Multimodal MRI Insights into Glymphatic Clearance and Blood-Brain Barrier Integrity in Healthy Aging

This study uses multimodal MRI to assess age-related changes in BBB permeability and glymphatic clearance in healthy adults, finding reduced Kw, increased FW, and decreased DTI-ALPS in older individuals.

A Multi-omic Atlas of Human Choroid Plexus in Alzheimer's Disease

This study creates a multi-omic atlas of the choroid plexus in Alzheimer's disease, identifying disease-associated cell state transitions and functional impairments.

Genetically determined alterations in inflammation and infection-associated genes are associated with hydrocephalus in patients of African Ancestry

The paper identifies TMEM208 as a transcriptome-wide predictor of hydrocephalus in African ancestry patients, linking it to inflammation and infection pathways.

Skull Bone Marrow Drainage and Its Associations with Inflammation, Sleep Quality, and Cognitive Performance

The paper investigates skull bone marrow drainage patterns using gadolinium imaging and links them to systemic inflammation, sleep quality, and cognitive performance in neurological patients.

Maturation of the glymphatic system confers innate resistance of the brain to Zika virus infection

This study shows that the maturation of the glymphatic system reduces susceptibility to Zika virus infection in mice, suggesting a protective role in the brain.

Cerebrospinal fluid flow and clearance driven by lateral ventricle volume oscillations

This study shows that lateral ventricle volume oscillations drive CSF flow and clearance, influenced by cortical blood-volume changes and physiological drivers.

Evidence for reduced choroid plexus volume in the aged brain

This study finds a significant reduction in choroid plexus volume in aged mice using two MRI protocols, supporting previous histology findings of age-related structural changes.

Sex and gender differences in perivascular space in early adolescence

This study examines sex and felt-gender differences in perivascular space (PVS) volume and count in adolescents, finding that felt-gender improves model fit for PVS count and both sex and felt-gender are associated with PVS volume and count.

Multi-omics Profiling of the Lateral Ventricle Choroid Plexus Reveals Developmental Cellular Remodeling, Early Immune Gene Activation, and a Novel Epithelial Subtype

The paper performs multi-omics analysis of choroid plexus across development in mice and rats, identifying cellular remodeling, immune gene activation, and a novel epithelial subtype.

Choroid plexus sex differences in secretory signalling and immune compartments

The paper identifies sex differences in the choroid plexus across multiple cell types and secretory signaling in mice, with similar patterns observed in humans.

Advection versus diffusion in brain ventricular transport

This study uses computational modeling and experiments to show that cilia drive advection of large particles while diffusion is key for small solute transport in brain ventricles.

Characterizing a hallmark of glymphatic insufficiency: Wasteosomes accumulate in periventricular white matter hyperintensities and exhibit complex relationships with mixed pathology, sclerotic index and perivascular space

The paper examines wasteosome accumulation in periventricular white matter hyperintensities and links it to vascular and pathological features in a mixed diagnostic cohort.

Structural Validation of the Intermediate Leptomeningeal Layer in the Human Central Nervous System

The paper identifies a fibrocellular intermediate leptomeningeal layer in the human CNS using anatomical and ultrastructural analysis, showing it divides the subarachnoid space into compartments and has immune-related features.

Quantitative evaluation of normal cerebrospinal fluid flow in the Sylvian aqueduct and perivascular spaces of the middle cerebral artery and circle of Willis via 2D phase-contrast MR imaging

This study measures CSF flow in the circle of Willis and middle cerebral artery using phase-contrast MRI, establishing baseline parameters and showing differences compared to the Sylvian aqueduct.

Cholinergic basal forebrain neurons regulate vascular dynamics and cerebrospinal fluid flux

The paper shows that cholinergic basal forebrain neurons influence vascular-CSF coupling and glymphatic flux in mice, suggesting a neurovascular mechanism for waste clearance in the brain.

A Novel Microsurgical Rat Model of Cervical Lymph Node-to-Vein Anastomosis (LNVA) for Studying Brain Lymphatic Outflow

This paper establishes a rat model for cervical lymph node-to-venous anastomosis to study brain lymphatic clearance and its role in neurodegeneration.

Relationships between measures of neurovascular integrity and fluid transport in aging: a multi-modal neuroimaging study

This study examines relationships between MRI-based measures of neurovascular integrity and fluid transport in older adults, finding age-related changes and stable inter-relationships among these metrics.

Biomarkers in cerebrospinal fluid sediments

The paper investigates whether discarded CSF sediments contain potential biomarkers for neurodegenerative diseases by analyzing CSF pellets and identifying disease-relevant proteins.

CSF pressure in fetal mice in utero: External factors pressurize the intraventricular space

The paper measures intraventricular CSF pressure in fetal mice in utero and shows it is influenced by external factors.

One night of sleep deprivation reduces spatially patterned human brain clearance: implications for simulated tau propagation

This study shows that sleep deprivation reduces brain clearance rates but preserves their spatial pattern, affecting tau propagation differently in a computational model.

Sequential emergence and contraction of epithelial subtypes in the prenatal human choroid plexus revealed by a stem cell model

Apolipoprotein-L1 G1 variant contributes to hydrocephalus but not to atherosclerosis in apolipoprotein-E knock-out mice

The paper investigates the role of APOL1 variants in cardiovascular and neurological diseases using mice, finding APOL1-G1 contributes to hydrocephalus but not atherosclerosis.

Total cerebral blood volume changes drive macroscopic cerebrospinal fluid flux in humans

A distinctive subset of microglia positioned at the paraventricular zone are dedicated to cleaning the cerebrospinal fluid

The paper identifies a subset of microglia in the paraventricular zone that clean cerebrospinal fluid by phagocytosing exogenous particles and prevents ventriculomegaly when removed.

The aging human brain exhibits reduced cerebrospinal fluid flow during sleep due to both neural and vascular factors

This study shows that aging reduces cerebrospinal fluid flow during sleep, linked to neural and vascular changes, and associated with gray matter atrophy.

CILIATED CELL DOMAINS WITH LOCALLY COORDINATED CILIARY MOTION GENERATE A MOSAIC OF MICROFLOWS IN THE BRAIN'S LATERAL VENTRICLES

The paper investigates flow patterns in the brain's lateral ventricles, revealing local microflows generated by clustered ciliated cells with varying polarity alignment.

In-silico molecular enrichment and clearance of the human intracranial space

This paper develops an in-silico model of human intracranial molecular transport using mixed-dimensional modeling and MRI data, showing how CSF flow and PVS size affect tracer enrichment.

Sleep increases propagation speed of physiological brain pulsations

The paper measures CSF flow velocity during sleep and finds it increases due to stronger vasomotor and respiratory pulsations, while cardiovascular speed remains unchanged.

Loss of Elp3 impairs the maturation tempo of brain ependymal cells

This study shows that loss of Elp3 in mouse forebrain causes microcephaly and hydrocephalus due to impaired ependymal cell maturation and cilia dysfunction.