Poxvirus research and outbreaks

Isoform-Resolved Temporal Remodeling of Transcriptome Architecture in Monkeypox Virus

The paper reanalyzes sequencing data to reconstruct full-length monkeypox virus transcripts and shows temporal changes in gene regulation and transcript structure.

Monkeypox virus M2 rewires nucleocytoplasmic transport to coordinate host translation suppression and immune evasion

This study identifies M2 as a multifunctional protein in monkeypox virus that blocks host gene expression by disrupting nucleocytoplasmic transport and altering signaling pathways, contributing to host shutoff and immune evasion.

Hairpin Architecture and Extended Sequence Context Shape APOBEC3 Mutagenesis in Monkeypox Virus at Different Genomic Scales

The paper reanalyzes APOBEC3 mutagenesis in MPXV genomes, showing mutations are enriched at TC motifs in hairpin loops and downstream guanine-rich sequences, with structural and sequence context playing distinct roles at different genomic scales.

The selection for cidofovir-resistant mutant vaccinia viruses is inhibited by coinfecting cidofovir-sensitive wildtypes

This study shows that coinfection of cidofovir-resistant and sensitive vaccinia viruses reduces the selection advantage of the resistant strain due to shared drug resistance traits.

Agentic-AI-ready genome-wide poxvirus-host interaction screen refined by a protein language model

The paper refines a genome-wide poxvirus-host interaction screen using a protein language model to improve hit prioritisation and provides the results as a community resource.

A human-derived two-antibody cocktail confers prophylactic and therapeutic protection against authentic Mpox virus.

This study identifies human two-antibody cocktails that neutralize Mpox virus in vitro and reduce viral loads in mice, offering potential therapeutic applications.

Single-dose Efficacy of a Next-Generation Mpox Vaccine Harnessing an Immunomodulatory Peptide

This paper develops a single-dose Mpox vaccine using an immunomodulatory peptide that enhances protection against orthopoxviruses without requiring adjuvants or multiple doses.

Atypical myxomatosis in European rabbits is caused by the recombinant myxoma virus involved in species jumping into hares

This paper investigates a new MYXV isolate, MYXV-Tol, which causes atypical myxomatosis in European rabbits and hares, showing it has evolved to cause a more severe, acute disease with distinct clinical features.

Comprehensive Profiling of Monkeypox Virus Antigens Identifies Potent Targets for Next-Generation mRNA Vaccine Development

This study identifies potent MPXV antigens for mRNA vaccine development by testing neutralizing antibodies against various surface proteins in mice.

First outbreak of Lumpy Skin disease in Catalonia, Spain, 2025-2026

The paper reports two LSDV genomes from the first LSD outbreak in Catalonia, Spain, placing them in clade 1.2 and linking them to recent European and African strains.

Architecture of a portal complex embedded in the poxvirus core

The paper determines the structure of the poxvirus portal complex and its pore, revealing their role in molecular transport and antiviral target potential.

Granularity screening identifies candidate genes involved in vaccinia virus induced LC3 lipidation

The paper uses an image-based screening approach to identify VACV genes that affect LC3 lipidation, revealing candidate viral membrane proteins involved in this process.

3,500 years of sheeppox virus evolution inferred from archaeological and codicological genomes

The paper reconstructs 3,500 years of sheeppox virus evolution using ancient genomes from archaeological and medieval parchment sources, showing divergence events and gene inactivation.

Historic and contemporary museum specimens implicate Northern Red-backed Vole (Clethrionomys rutilus) as borealpox host as early as 1990s

The study identifies Northern Red-backed Voles as potential BRPV hosts using museum specimens and field samples, showing BRPV presence since at least 1998.

Emergence of mpox in Guinea: sporadic clade IIa cases and a clade IIb upsurge

The paper reports the emergence of mpox in Guinea, identifying both clade IIa and IIb strains, with clade IIb associated with sustained human-to-human transmission.

Adaptive Remodeling of the MPXV B21R Receptor-Binding Domain Enhances DC-SIGN Interaction and Identifies Conserved CTL Targets for T-Cell Vaccine Development

This study analyzes the global epidemiology of Mpox and identifies mutations in the B21R protein that enhance DC-SIGN interaction and suggest T-cell vaccine targets.

Oral Administration of the carboxylic acid ester prodrug NHC SN_9 protects mice from lethal Orthopoxvirus challenge: Implications for the Treatment of Monkeypox

This study evaluates the antiviral efficacy of SN_9, a prodrug of NHC, against orthopoxviruses in mice, showing significant survival and reduced disease severity.

MPXV Clade IIb virus infection in mice leads to prolonged viral replication, macrophage infiltration, and decreased spermatogenesis in the testes.

Lower pathogenicity but similar genital shedding of monkeypox virus clade Ib compared to clade Ia in a rodent model

Structure and functional analyses of Vaccinia virus entry- fusion complex component J5 protein

The paper determines the NMR structure of J5 protein and identifies functional residues critical for EFC integrity and membrane fusion in Vaccinia virus entry.

Evolutionary Variation of Poxvirus Genome Architecture

This study analyzes poxvirus genome architecture across the family, finding correlations between genome size, coding density, GC-content, and protein distribution, with implications for viral evolution and biology.

ISG15 Differentially Modulates Clade Ib and II MPXV Infection in MEF cells

This study shows ISG15 modulates Clade Ib and II MPXV infection differently in MEF cells, with clade-specific effects on viral replication and immune evasion.

Enhanced mouse virulence of mpox virus clade Ib over clade IIb despite genomic changes caused by human-to-human transmission

This study compares the virulence of mpox virus clade Ib and IIb, finding clade Ib is more virulent in mice despite genomic changes from human-to-human transmission.

High genetic diversity of mpox virus (MPXV) in three different rodent species in the Democratic Republic of the Congo (DRC)

The paper identifies MPXV diversity in three rodent species in the DRC, showing multiple clades and proximity to human populations.

In situ cryo-electron tomography of vaccinia virus exit from infected cells

This study uses cryo-electron tomography and SIM to analyze vaccinia virus egress, revealing septin and clathrin roles in viral spread and release.

Comment on "Inverted repeats in the monkeypox virus genome are hot spots for mutation"

The paper reanalyzes MPXV mutation data and finds no statistically significant enrichment of APOBEC-signature mutations in cruciform structures formed by inverted repeats.

Highly efficient anogenital transmission of clade Ia mpox virus associated with increased shedding.

This study investigates mpox virus transmission in prairie dogs, finding that anogenital mucosal routes lead to high shedding and efficient transmission.

Development of a replication-defective MPXV platform for fundamental and therapeutic research

This paper develops a replication-defective MPXV platform for antiviral research and virology studies by engineering particles that recapitulate key viral life cycle stages without requiring high-containment facilities.

Pathogenicity and transmissibility of Monkeypox virus in dormice

This study evaluates MPXV pathogenicity and transmissibility in African dormice, finding high susceptibility, lethal infections, and both direct and limited airborne transmission.

Establishing a Digital PCR-Based Reference Measurement Procedure for Monkeypox Virus: An Inter-laboratory Assessment and Standardization Study

This paper establishes a ddPCR-based reference measurement procedure for MPXV quantification, demonstrating high precision and inter-laboratory consistency.