Per- and polyfluoroalkyl substances research

PPARα genotype impacts bone quality and perfluorooctanoic acid-induced effects

This study examines how PPAR genotype affects bone quality and PFOA-induced effects in mice, finding PPAR-dependent changes in bone parameters and osteoblast activity.

Early-life PFAS exposure induces systemic metabolic alterations in plasma and brain in mice

This study shows that early-life PFAS exposure causes sex-dependent metabolic changes in plasma and brain of mice, with females showing more extensive alterations.

Mechanism-guided Discovery of Fluoroacetate Dehalogenase (FAcD) Variants for Enzymatic PFAS Defluorination

The paper presents DeFluorX, a pipeline using Boltz-2 to identify FAcD variants for PFAS defluorination by analyzing geometric and energetic factors in enzyme-PFAS complexes.

TFA-defluorinating microbial consortium achieved with analogue enrichment

This study identifies a microbial consortium capable of degrading trifluoroacetate (TFA) by enriching for microorganisms that can metabolize structurally similar compounds.

Volatile Metabolic Signatures Reveal Early Pulmonary Responses to PFAS Exposure

This study identifies volatile organic compound (VOC) changes in lung cells exposed to PFAS, linking them to metabolic and transcriptional alterations.

Exposure to a mixture of long-chain PFAS disrupts ovarian follicle development, ovulation, and luteinization in female mice

This study shows that exposure to a mixture of long-chain PFAS disrupts ovarian function in female mice, affecting follicle development, ovulation, and luteal function.

Human Lactoferrin is a Novel PFAS Target: Implications for Neo-natal Immune Function and Protein Stability

This study shows that PFAS bind and destabilize human lactoferrin, affecting its thermal stability and potentially impacting immune function.

Acute Exposure to Perfluorooctanoic Acid (PFOA) During Cardiomyogenesis disrupts Transcriptional and Electrophysiological Profiles in Differentiated Myocytes

This study shows that PFOA exposure during cardiomyocyte differentiation alters gene expression and electrophysiological function in hiPSC-CM, with effects lasting after exposure stops.

Prenatal exposure to PFAS and multimodal structural brain development across childhood

This study examines the impact of prenatal PFAS exposure on childhood brain development using MRI data, finding associations with cortical surface area and white matter microstructure changes.

Plant functional defects experienced upon growth under Per-/Poly-fluoroalkyl substances (PFAS) conditions

This study examines the effects of PFAS on mung bean growth, showing chemical-specific impacts on development, water dynamics, and immune responses.

Exposure Duration Shapes the Hepatic Response to GenX: Divergent Acute and Chronic Transcriptomic Profiles Reveal Non-Monotonic Dose Effects and Increased Sensitivity in Human Liver Spheroids

Per-and polyfluoroalkyl substances (PFAS) driven reorganization of brain metabolism is impacted by resident microbiota

This study shows that gut microbiota modulates PFAS-induced metabolic changes in the brain across different regions and tissues.

Oral exposure to Perfluorooctanoic acid disrupts the microbiota-gut-liver axis and enhances the severity of chemically induced colitis in mice.

This study shows that early-life PFOA exposure disrupts the gut-liver axis and worsens DSS-induced colitis in male mice but not in genetically predisposed Il10 KO mice.

Aerobic GenX Defluorination by a Wastewater Cladosporium halotolerans Strain with a Genomically Expanded Haloacid Dehalogenase Repertoire

This paper identifies a wastewater Cladosporium halotolerans strain capable of aerobically degrading GenX, a PFAS, through a genomically expanded haloacid dehalogenase repertoire and a phased transcriptional program.

Integrative computational toxicology reveals PFOS and PFHxS associated inflammatory keratinocyte niches in psoriasis through exposure transcriptomics, single-cell spatial mapping and token-aware virtual perturbation

Tracing PFAS Transfer from Mother to the Fetoplacental Unit: Insights from Trimester-Specific Maternal Serum Profiles

The paper examines PFAS transfer from mother to fetoplacental unit using trimester-specific maternal serum profiles and finds early-to-mid gestation measures are most predictive of fetal exposure.

PFOA exposure amplifies normal developmental gene expression programs in the African Killifish, Nothobranchius furzeri

This study shows PFOA exposure amplifies normal developmental gene expression programs in African killifish, with greater effects post-hatching than during embryonic stages.

Exposure to perfluorooctanoic acid accelerates Drosophila melanogaster juvenile development and disrupts mitochondrial metabolism

This study shows PFOA exposure accelerates Drosophila melanogaster juvenile development and disrupts mitochondrial metabolism, leading to increased sensitivity to environmental stress.

Global patterns and predictors of PFAS contamination in odontocetes

This study assesses global PFAS contamination in odontocetes by analyzing 713 liver samples, finding genus and location as strongest predictors, with higher concentrations in males and younger individuals and increasing trends in the Pacific.

High-throughput protein target mapping enables accelerated bioactivity discovery for ToxCast and PFAS compounds

The paper uses high-throughput affinity-selection mass spectrometry to identify protein targets of ToxCast and PFAS compounds, discovering novel interactions and revealing distinct binding patterns of legacy and replacement PFAS.

PFAS exposure is associated with accelerated epigenetic ageing in a wild marine mammal

This study links PFAS exposure to accelerated epigenetic ageing in wild common dolphins using DNA methylation and a species-specific epigenetic clock.

Environmental PFOA Exposure Alters Early Developmental Programming during the Maternal Zygotic Transition

This study shows that PFAS exposure during the maternal-to-zygotic transition disrupts gene regulatory networks and alters developmental outcomes in zebrafish.

Developmental exposure to a PFAS mixture impairs the anamnestic response to influenza A virus infection in mice

This study shows that developmental exposure to a PFAS mixture reduces influenza A virus-specific antibody levels and affects immune cell populations differently in male and female mice.

Systematic toxicological study of PFOS/PFOA co-exposure driving prostate cancer: Core target identification, TME immune remodeling, and combination drug prediction

This paper identifies core targets and mechanisms of PFOS/PFOA-induced prostate cancer and predicts combination drug therapy using computational methods.

Per- and Polyfluoroalkyl Substances Induces Salt-Sensitive Hypertension by Upregulating Epithelial Sodium Channel - The First Experimental Evidence Supporting Causality

This paper shows that PFAS exposure causes salt-sensitive hypertension and kidney injury in mice by increasing ENaC activity in the kidney.

Selective Hydrolytic Defluorination of Branched Perfluorooctanoic Acid Isomers by a Haloacid Dehalogenase

This paper demonstrates that a haloacid dehalogenase selectively defluorinates branched PFOA isomers, expanding the known catalytic scope of this enzyme family.

Epigenetic changes induced by developmental PFAS exposure in zebrafish associate with behavioral alterations in unexposed offspring

This study shows that PFAS exposure during development causes transgenerational behavioral effects in zebrafish through epigenetic changes that persist in unexposed offspring.

Proteome-wide reverse molecular docking reveals folic acid receptor as a mediator of PFAS-induced neurodevelopmental toxicity

This study identifies folic acid receptor beta as a mediator of PFAS-induced neurodevelopmental toxicity using zebrafish models and reverse molecular docking.

PFOS Disrupts Membrane Signaling and Epithelial Integrityin Fallopian Tube Cells

This study shows PFOS exposure disrupts membrane signaling and epithelial integrity in fallopian tube cells by altering stress-response pathways and lipid homeostasis.

Natural variation in transplacental transfer efficiency exposes distinct transcriptional network architectures of PFAS effects on birth weight and gestational age

The paper shows PFAS affect birth weight and gestational age through distinct transcriptional network architectures, with network position, not fold-change, determining mediator importance.