Psychedelics and Drug Studies

Multidimensional characterization of the physiological and behavioral effects of TCB-2 in mice

This study examines the effects of TCB-2 on multiple physiological and behavioral measures in mice, finding distinct effects across different metrics and partial modulation by a 5-HT2A antagonist.

Mapping excitatory synaptic plasticity evoked by single-dose psilocybin in mice

This study investigates how a single dose of psilocybin affects excitatory synaptic plasticity in mice, showing region-specific changes linked to serotonin receptor expression.

Mind-manifesting? Examining naturalistic reports from psychedelics, cannabis, meditation, and dreams from the ALTERD mobile application

The paper analyzes 2,242 naturalistic reports from the ALTERD app to compare the phenomenology of psychedelics, cannabis, meditation, and dreams, finding psychedelics align with dreams and meditation in some aspects but show unique transformative features.

Identifying factors that contribute to the behavioral effects of psilocybin in preclinical mouse models

The paper identifies biological and experimental factors influencing psilocybin's behavioral effects in mice using a large dataset and data-driven analyses.

The psychedelic DOI decreases the modularity of the cortical network by increasing cortico-cortical and thalamo-cortical functional influence

This study shows that the psychedelic DOI reduces cortical network modularity by increasing functional influence between cortical domains in mice.

Estimating Cardiac 5-HT2B Safety Margins for Repeated Low-Dose Psilocybin Using an Exposure-Response Model

This paper develops an exposure-response model to estimate cardiac safety margins for repeated low-dose psilocybin, finding a large safety margin due to psilocin's low-efficacy partial agonism and short half-life.

Psychedelic drug action at dendrites is gated by behavioral state and serotonin receptors

This study shows psilocybin increases dendritic calcium activity in mice during quiet wakefulness, dependent on 5-HT2A receptors, and disrupts the link between calcium signaling and spine formation.

One-shotted: psychedelic insights are uniquely intense, meaningful and ineffable

This study compares the phenomenology of insight across psychedelic experiences and other contexts, finding that psychedelic insights are more intense, meaningful, and impactful on belief change than laboratory or everyday insights.

Integrated 5-HT2A-TrkB and G protein signaling in serotonergic psychedelic responses

This study investigates the molecular mechanisms of serotonergic psychedelics using a neural stem cell model, revealing an integrated 5-HT2A-TrkB signaling network involved in neuroplasticity and metabolic responses.

Brain-epigenome wide association study (BEWAS) on the effects of two emerging psychedelics: ketamine & MDMA

This study uses BEWAS to identify DNA methylation changes in brain-enriched genes after ketamine and MDMA treatment, revealing shared epigenetic mechanisms linked to neuroplasticity.

Psilocybin selectively rescues cognitive flexibility impairments caused by aberrant prefrontal error signaling

This study shows psilocybin improves cognitive flexibility in mice with specific circuit-level deficits, depending on the cause, and identifies cellular mechanisms underlying its therapeutic effects.

Dissociating the Hallucinogenic and Neuroplastic Effects of Psilocybin

This study investigates how 5-HT2AR signaling in L5 PyrNs contributes to psilocybin-induced synaptic remodeling versus hallucinations in rodents.

Animal models in psychedelic research - Tripping over translation

This paper reviews 266 rodent psychedelic studies to identify methodological gaps in preclinical research and proposes improvements for better translational relevance.

Distinct brain responses to psilocybin and escitalopram in depression captured by the Fluctuation-Dissipation Theorem

This study compares brain responses to psilocybin and escitalopram in depression using the Fluctuation-Dissipation Theorem, finding distinct non-equilibrium dynamics and responder differentiation.

EEG microstate dynamics during psilocybin intoxication relate to acute experience and persisting psychological changes

This study examines EEG microstate dynamics during psilocybin intoxication and finds correlations between acute neural changes and long-term psychological effects.

Lysergic acid diethylamide reverses aging- and neurodegeneration-associated brain transcriptional programs

This study shows that LSD induces gene expression patterns opposing aging and neurodegeneration in the brain, suggesting potential therapeutic effects through transcriptional reversal.

LSD Relaxes Structural Constraints on Brain Dynamics: A Connectome Harmonic MEG Study

This study uses MEG and connectome harmonics to show LSD reduces structure-function coupling in low-frequency brain activity, linking this to ego dissolution and altered network dynamics.

Epigenome-wide Association Study of Psilocybin-Induced Methylome Changes in Alcohol Use Disorder

This study identifies DNA methylation changes in AUD patients after psilocybin treatment, finding significant CpG sites and methylation patterns linked to neuroplasticity and immune functions.

Psilocybin modulates social behaviour in male and female mice in a time-dependent manner

This study shows psilocybin affects social behavior in male and female mice differently over time, with sex-specific changes in social preference and dopamine signaling.

Acute DOI exposure drives cortical hyperexcitability and functional network remodeling

This study shows that acute DOI exposure increases cortical firing rates and alters functional network structure in rat cultures, with ketanserin + DOI reducing bursting while preserving path-length shortening.

Lysergic acid diethylamide pretreatment prolongs brain-stimulation induced neural activity

This study shows that LSD pretreatment enhances the lasting effects of brain stimulation on neural activity in rats.

LSD persistently disrupts affective pain processing

This study shows that a single dose of LSD in rats reduces pain affect by suppressing nociceptive responses in the anterior cingulate cortex.

Characterizing Resting-State Brain Dynamics with Frequency-Resolved EEG Microstates: Parallel Analyses of Psilocybin Microdosing and Acute Inhaled DMT

This study uses frequency-resolved EEG microstate analysis to compare resting-state brain dynamics under psilocybin microdosing and acute inhaled DMT, finding frequency-specific alterations in both conditions.

Human brain changes after first psilocybin use

This study investigates brain changes after a single high-dose psilocybin administration, finding anatomical and functional alterations linked to improved well-being and cognitive flexibility.

Psilocybin ameliorates neuropathic pain-like behaviour in mice and facilitates gabapentin-mediated analgesia

This study shows psilocybin reduces neuropathic pain in mice and enhances gabapentin's effectiveness through 5-HT2A receptor mechanisms.

Distinct Modulatory Effects on Affective Biases by Different Serotonergic Psychedelics and MDMA in Male Rats: Possible Implications for Antidepressant Effects

This study investigates how different serotonergic psychedelics and MDMA affect affective biases in male rats, finding varied impacts on memory and new experiences that may relate to their antidepressant potential.

Structural plasticity and enhanced fear extinction following psilocybin in chronically stressed mice

This study shows psilocybin increases dendritic spine density and improves fear extinction in chronically stressed mice.

Serotonergic Polypharmacology of 2-Halogenated Tryptamines

This study designs and tests 2-halogenated tryptamines to reduce psychoactive and cardiotoxic effects while retaining therapeutic serotonergic activity.

Psilocybin reshapes cortical inhibition through selective interneuron recruitment

This study shows psilocybin selectively affects GABAergic interneurons in the mouse medial frontal cortex, reducing somatostatin-expressing and increasing parvalbumin-expressing neuron activity.

Enhancing cGMP signaling with psilocybin reduces head twitch and restructures the synaptic proteome while maintaining antidepressant response

This study combines psilocybin with a PDE9 inhibitor to reduce head-twitch response and alter synaptic proteome while preserving antidepressant effects.