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Across-breed analyses of genome-wide association studies for stature and mammary gland morphology in cattle reveal pleiotropic effects of the Friesian POLLED haplotype

The paper performs genome-wide association studies in cattle to identify QTL for stature and mammary gland morphology, finding pleiotropic effects of the Friesian POLLED haplotype on mammary traits.

A genome-wide MAGIC kit for recombinase-independent mosaic analysis in Drosophila

The paper introduces a genome-wide gRNA-marker kit for MAGIC in Drosophila, enabling clonal analysis of previously inaccessible genetic elements and tissues.

Genome-scale mapping of variant, enhancer and gene function in primary human CD4+ T cells

The paper maps variant, enhancer, and gene function in primary human CD4+ T cells by combining Perturb-seq of regulatory elements and genes, identifying CRE-gene pairs and linking variants to disease-related programs.

The Illusion of Polygenicity in Poolseq studies: Insufficient Power Can Mask Simple Genetic Architectures

This paper shows that low statistical power in pool-seq GWAS can create the illusion of polygenicity by masking simple genetic architectures through noise.

Recessive POPDC1 Truncation Causes Lethal Short-QT Pattern Arrhythmogenic Cardiomyopathy with Multi-Ion Channel Remodeling and Ankyrin-G Scaffold Disruption

Pennycress (Thlaspi arvense L.) Seed Persistence in the Field After Two Years

This study evaluates the long-term viability of wild-type and gene-edited pennycress seeds under different field conditions, finding that gene-edited seeds lose viability faster than wild-type seeds.

A sequence motif for DNA double-strand break and telomere healing during programmed DNA elimination

The paper identifies a sequence motif, SFE, that is necessary and sufficient for generating DNA double-strand breaks and telomere healing during programmed DNA elimination in nematodes.

Validation of tissue-specific RNAi systems in C. elegans reveals a converging role for polyubiquitin UBQ-1/UBC in vitellogenin metabolism and lifespan

Assembly of a pangenome uncovers novel non-reference unique insertion sequences in cattle highlighting their genetic diversity

The paper constructs a cattle pangenome to identify novel non-reference unique insertions (NRUIs) and links them to economically important traits.

The effect of long-range linkage disequilibrium on allele-frequency dynamics under stabilizing selection

The paper shows that linkage disequilibria from stabilizing selection slow allele-frequency dynamics and provides more accurate predictions than previous formulas.

Mitochondrial redox homeostasis links organellar stress surveillance to germline and somatic integrity in Caenorhabditis elegans

This study shows that loss of mitochondrial glutathione reductase and thioredoxin reductase in C. elegans causes growth, fertility, and muscle defects, activates a constitutive UPRmt, and alters mitochondrial morphology.

The chromatin remodeling complex PRC2 safeguards cell fate in alveolar epithelial type 2 cells

This study shows that PRC2 maintains AT2 cell fate in the adult lung by preventing transitions to ABI and basal-like states, both in vitro and in vivo.

Heat stress-induced condensation of G3BP1 in perinuclear P-bodies in C. elegans' germline

This study investigates the role of GTBP-1 in heat stress response in C. elegans germline, showing its involvement in stress granule formation and reproductive homeostasis.

Circadian Dysregulation in Aging Alters Senescence and Inflammatory Pathways in a Sex- and Time-of-Day Dependent Manner

This study shows that aging disrupts circadian rhythms, leading to sex- and time-of-day-dependent changes in senescence and inflammatory pathways in mice.

AAV-Mediated Dual-Gene Therapy Restores Metabolic Function in Mice with Propionic Acidemi

This study demonstrates that dual-gene AAV therapy restores metabolic function and shows long-term safety in a mouse model of propionic acidemia.

Genetic analysis of triplicated genes affecting sex-specific skeletal deficits in Down syndrome model mice

The paper compares skeletal phenotypes between two Down syndrome mouse models, Ts65Dn and Ts66Yah, using a novel PCA-based method to assess the impact of non-Hsa21 trisomic genes on bone structure and function.

Genetic and environmental determinants of multicellular-like phenotypes in fission yeast

The paper identifies genetic and environmental factors influencing multicellular-like phenotypes in fission yeast through experimental and genomic analyses.

Tumor-induced orexigenic imbalance lowers protein appetite and drives early organ wasting symptoms

The paper identifies tumor-induced factors that reduce brain NPF signaling, leading to low protein appetite and early organ wasting in a fly model of cancer cachexia.

Identification of a miRNA signature for schizophrenia in plasma-derived extracellular vesicles

The paper identifies a miRNA signature in plasma-derived extracellular vesicles associated with schizophrenia and links one miRNA to working memory and white matter integrity.

Massive-scale single-nucleus multi-omics identifies novel rare noncoding drivers of Parkinson's disease

The paper identifies rare noncoding variants associated with Parkinson's disease using multi-omic data from over 3.3 million nuclei.