B. Li

Cigarette smoking promotes the spread of antimicrobial resistance in the human lung and the environment

This study shows cigarette smoke increases antimicrobial resistance transfer between bacteria in lung and environmental settings.

Heart-on-a-chip model of immune-induced cardiac dysfunction reveals the involvement of free mitochondrial DNA and therapeutic effects of endothelial exosomes

This paper develops a heart-on-a-chip model to study immune-induced cardiac dysfunction, identifying mitochondrial DNA as a key factor and showing therapeutic potential of endothelial exosomes.

Cell networks in the mouse liver during partial hepatectomy

The paper identifies and validates novel signaling interactions in liver regeneration using a computational platform analyzing cell-cell interactions in mouse livers.

Integrative spatial analysis reveals a multi-layered organization of glioblastoma

This study uses spatial transcriptomics and proteomics to reveal three modes of cellular organization in glioblastoma, with hypoxia driving a 5-layered global architecture.

Mechanical Force Imprints Neutrophils to Orchestrate Pulmonary Homeostasis

This study identifies mechanical sensing via Piezo1 as critical for lung-specific neutrophils to maintain pulmonary homeostasis and respond to infection.

Recombinant outer membrane vesicles coupled with cytokines act as high-performance adjuvants against Helicobacter pylori infection in mice

This paper shows recombinant outer membrane vesicles with cytokines enhance immune responses and H. pylori clearance in mice compared to traditional adjuvants.

AGILE Platform: A Deep Learning-Powered Approach to Accelerate LNP Development for mRNA Delivery

AGILE uses deep learning and combinatorial chemistry to rapidly design and evaluate ionizable lipids for mRNA delivery, revealing cell-specific preferences for lipid structures.

Noncanonical TRAIL Signaling Promotes Myeloid-Derived Suppressor Cell Abundance and Tumor Progression in Cholangiocarcinoma

This study shows that TRAIL+ cancer cells use noncanonical TRAIL signaling in MDSCs to promote their abundance and tumor progression in cholangiocarcinoma.

A single-cell atlas of the single versus multiple parous Hu Sheep ovary

This study constructs a single-cell atlas of Hu sheep ovaries comparing high-litter (HLS) and low-litter (LLS) sheep, identifying molecular differences in granulosa cells that affect reproductive outcomes.

Synchrony of Bird Migration with Avian Influenza Global Spread; Implications for Vulnerable Bird Orders

The paper uses phylodynamic analyses to link bird migration patterns with the global spread of HPAIV H5 clade 2.3.4.4, identifying vulnerable bird orders and highlighting Suliformes and Ciconiiformes as important in virus dispersal.

Prognostic Gene Signature for lung adenocarcinoma with a Higher Risk for Treatment Failure and Accelerated cell cycle and cell proliferation Pathway Activity

The paper identifies a 78-gene prognostic signature for lung adenocarcinoma that correlates with cell cycle activity and treatment response to PIM inhibitors.

Latitudinal scaling of aggregation with abundance and its consequences for coexistence in species rich forests

The paper examines latitudinal patterns in species aggregation and abundance, showing how these patterns affect coexistence in forests and introduces a framework to model their impact on extinction risk.

Amoeboid cells undergo durotaxis with soft end polarized NMIIA

The paper shows amoeboid cells, like T cells and neutrophils, can durotax by polarizing NMIIA towards softer substrates, and this behavior is conserved in Dictyostelium.

A 3D-printed flow-cell for on-grid purification of electron microscopy samples directly from lysate

This paper introduces a 3D-printed flow-cell device for on-grid affinity purification of cryo-EM samples directly from lysate, aiming to improve sample preparation efficiency.

Integrated multi-omics data reveals the molecular subtypes and the contruction of novel signature to aid Immunotherapy

The paper identifies two molecular subtypes of lung adenocarcinoma using multi-omics data and develops a signature to predict immunotherapy response.

Antigen-presenting type-I conventional dendritic cells facilitate curative checkpoint blockade immunotherapy in pancreatic cancer

The paper shows that type-I conventional dendritic cells enhance checkpoint blockade immunotherapy effectiveness in pancreatic cancer when combined with pancreatitis.

Isolation of ACE2-dependent and -independent sarbecoviruses from Chinese horseshoe bats

The paper isolates ACE2-dependent and -independent sarbecoviruses from Chinese horseshoe bats using a new virus isolation protocol.

Spatial transcriptomic atlas of shoot organogenesis in tomato callus

This study creates a spatial transcriptomic atlas of tomato callus during shoot regeneration, identifying cell types and developmental trajectories.

Computational Modelling of Immune Interaction and Epidermal Homeostasis in Psoriasis

This paper develops a 3D agent-based model of psoriasis to simulate immune cytokine-induced epidermal hyperproliferation and validate it against in vivo cell population data.

Fiberbots: Robotic fibers for high-precision minimally invasive surgery

This paper develops robotic fibers (fiberbots) that enable high-precision motion through thermal expansion, demonstrating scalability and integration with medical devices for potential applications in surgery and biomedical engineering.

Oncogenic KrasG12D specific non-covalent inhibitor reprograms tumor microenvironment to prevent and reverse early pre-neoplastic pancreatic lesions and in combination with immunotherapy regresses advanced PDAC in a CD8+ T cells dependent manner

This study shows that MRTX1133, a KrasG12D inhibitor, reduces early pancreatic lesions and, when combined with immunotherapy, regresses advanced PDAC by enhancing CD8+ T cell activity.

GLI1 facilitates rheumatoid arthritis by collaborative regulation of DNA methyltransferases

This study shows GLI1 promotes rheumatoid arthritis by regulating DNA methyltransferases, leading to M1 macrophage polarization and osteoclast activation, and suggests GLI1 inhibitors as potential treatments.

Mitochondrial Genome Analysis and Phylogeny and Divergence Time Evaluation of the Strix aluco

This study reports the first complete mitochondrial genome of Strix aluco, identifies its divergence time, and links geographic and climatic factors to its speciation.

High frequency soil polarization can phenotype crop roots noninvasively

This study shows that high-frequency soil polarization (ECsoil) can accurately measure root volume and distribution in the field, with potential for noninvasive root phenotyping.

Prenatal Carotenoid Supplementation with Lutein or Zeaxanthin Ameliorates Oxygen-Induced Retinopathy (OIR) in Bco2-/- Macular Pigment Mice

This study shows prenatal lutein or zeaxanthin supplementation reduces oxygen-induced retinopathy in Bco2-/- mice by lowering vaso-obliteration and intravitreal neovascularization.

Prewhitening and Normalization Help Detect a Strong Cross-Correlation Between Daily Wastewater SARS-CoV-2 RNA Abundance and COVID-19 Cases in a Community

The paper shows that prewhitening and normalization improve the detection of a strong cross-correlation between wastewater SARS-CoV-2 RNA and clinical COVID-19 cases.

cpSRP54 and FtsH cooperate thylakoid membrane associated proteostasis during de-etiolation in Arabidopsis thaliana

The paper shows cpSRP54 and FtsH work together in thylakoid membrane protein quality control during de-etiolation in Arabidopsis, and provides a trackable marker for monitoring their activities.

Individual bat viromes reveal the co-infection, spillover and emergence risk of potential zoonotic viruses

The study analyzes viral diversity in individual bats to assess co-infection, spillover, and zoonotic risk of potential viruses.

Inhibition of ADORA1 attenuates hepatic steatosis by gut microbiota-derived acetic acid from Astragalus polysaccharides

The paper reports that some data could not be replicated and the manuscript was withdrawn, with parts of the data published elsewhere.

Mapping single-cell responses to population-level dynamics during antibiotic treatment

The paper maps single-cell lysis probabilities to population-level biomass dynamics during antibiotic treatment, showing how filamentation extent influences lysis and validates this with experiments.