F. Wu

Fuzzy Supertertiary Interactions within PSD-95 Enable Ligand Binding

This study uses molecular dynamics and FRET to analyze PSD-95's conformational dynamics and shows how its flexible structure enables ligand binding.

HOXD13 is a direct EWS-FLI1 target and moderates fusion-dependent transcriptional states

The paper identifies HOXD13 as a direct target of EWS-FLI1 and shows it modulates transcriptional states in Ewing sarcoma by antagonizing EWS-FLI1-dependent gene repression.

Combating the SARS-CoV-2 Omicron variant with non-Omicron neutralizing antibodies

This study designs bispecific antibodies from non-Omicron neutralizing antibodies that effectively neutralize the Omicron variant and related sarbecoviruses.

The predicted bZIP transcription factor ZIP-1 promotes resistance to intracellular infection in Caenorhabditis elegans

This study identifies ZIP-1, a bZIP transcription factor, as a central regulator of the Intracellular Pathogen Response in C. elegans, enhancing resistance to viral and fungal infections.

Single cell genome sequencing of laboratory mouse microbiota improves taxonomic and functional resolution of this model microbial community

The paper uses single-cell genome sequencing of mouse stool to improve taxonomic and functional resolution of the mouse gut microbiome by identifying novel species and enhancing metagenomic analysis.

Global and context-specific transcriptional consequences of oncogenic Fbw7 mutations

This study examines the transcriptional effects of Fbw7 mutations in colorectal cancer cells and identifies context-specific regulatory changes and co-regulated genes like CIITA.

Metabolic Derangement in Polycystic Kidney Disease Mouse Models Is Ameliorated by Mitochondrial-Targeted Antioxidants

This study shows mitochondrial-targeted antioxidants reduce oxidative stress and metabolic issues in PKD mouse models, improving disease progression and restoring metabolic pathways.

Effect of ORF7 of SARS-CoV-2 on the chemotaxis of monocytes and neutrophils in vitro

This study shows that SARS-CoV-2 ORF7 increases monocyte chemotaxis via CCL2 and decreases neutrophil recruitment via reduced IL-8.

A cooperative network at the nuclear envelope counteracts LINC-mediated forces during oogenesis in C. elegans

The paper investigates mechanical forces during oogenesis in C. elegans and finds that a lamin meshwork counteracts LINC-mediated forces to prevent nuclear collapse.

Recruitment of Polo-like kinase couples synapsis to meiotic progression via inactivation of CHK-2

The paper shows that PLK-2 inactivates CHK-2 in C. elegans to promote crossover formation and meiotic progression after synapsis.

Class II LBD genes ZmLBD5 and ZmLBD33 regulate gibberellin and abscisic acid biosynthesis

This study identifies ZmLBD5 and ZmLBD33 as class II LBD genes in maize that regulate gibberellin and abscisic acid biosynthesis, affecting plant growth and drought tolerance.

Sex-specific phenotypic effects and evolutionary history of an ancient polymorphic deletion of the human growth hormone receptor

This study investigates the evolutionary history and phenotypic effects of the GHRd3 deletion, finding sex- and environment-dependent impacts on growth and metabolism.

The plant immune receptors NRG1.1 and ADR1 are calcium influx channels

The paper identifies NRG1.1 and ADR1 as plant immune receptors that function as calcium-permeable channels to induce cell death.

Neuromodulation of Behavioral Specialization: Tachykinin Signaling Inhibits Task-Specific Behavioral Responsiveness in Honeybee Workers

This study identifies tachykinin peptides as regulators of task-specific behavioral responsiveness in honeybee workers by manipulating their expression and observing behavioral outcomes.

High-throughput tandem-microwell assay for ammonia repositions FDA-Approved drugs to Helicobacter pylori infection

This study identifies FDA-approved drugs that inhibit urease activity in H. pylori, offering potential new treatments for infections.

Expression analysis of photosynthesis-related genes in albino Artocarpus heterophyllus seedlings leaves

The paper investigates photosynthesis-related gene expression in albino Artocarpus heterophyllus seedlings, finding down-regulated genes in pigment synthesis and photosynthesis pathways.

Fitness benefit plays a vital role in the retention of the Pi-ta susceptible alleles

The paper shows that susceptible Pi-ta alleles are retained due to their fitness benefit by acting as an off-switch for immune signaling.

Crosstalk between chloroplast protein import and the SUMO system revealed through genetic and molecular investigation

The paper shows that the SUMO system regulates TOC complex stability and chloroplast development in Arabidopsis by stabilizing TOC proteins.

Intrinsic and extrinsic factors collaborate to activate pharyngeal satellite cells without muscle injury

This study identifies intrinsic and extrinsic factors that drive increased basal activity of pharyngeal satellite cells compared to limb muscle satellite cells.

Lateral mechanical impedance rather than frontal, promotes cortical expansion of roots

The paper shows that lateral mechanical impedance, not frontal, promotes cortical expansion and radial growth in maize roots.

Pex24 and Pex32 tether peroxisomes to the ER for organelle biogenesis, positioning and segregation

This study identifies Pex24 and Pex32 as ER proteins tethering peroxisomes to the ER, essential for biogenesis, positioning, and segregation, with Pex11 facilitating their function.

A Heat Stress Responsive NAC Transcription Factor Heterodimer Plays Key Roles in Rice Grain Filling

This study identifies two heat stress-responsive NAC transcription factors in rice that regulate grain filling and sugar transport through a heterodimer complex.

Complete genome characterisation of a novel coronavirus associated with severe human respiratory disease in Wuhan, China

The paper characterizes the complete genome of a novel coronavirus, WHCV, linked to a respiratory outbreak in Wuhan, finding it closely related to SARS-like bat coronaviruses.

Sequestration of Methane by Symbiotic Deep-Sea Annelids: Ancient and Future Implications of Redefining the Seep Influence

The paper identifies new deep-sea annelid-bacterial symbioses that actively consume methane, expanding the known spatial extent of methane seeps and their ecological impact.

α1A-adrenoceptor inverse agonists and agonists modulate receptor signalling through a conformational selection mechanism

This study shows how different ligands modulate the conformational states of the α1A-adrenoceptor through a conformational selection mechanism, as revealed by NMR analysis of labeled receptor mutants.

ER stress drives ER-to-Golgi trafficking of ATF6 by blocking its membrane insertion

The paper challenges the current model of ER stress sensing by showing ATF6 is sorted to the Golgi as a peripheral membrane protein, and translocon inhibition drives its activation.

Transposable elements contribute to regulatory hub stress-related long noncoding RNAs in Maize

The paper identifies and characterizes lncRNAs in maize, finding that many are derived from transposable elements and play regulatory roles in abiotic stress responses.

Field decomposition of Bt-506 corn leaf and its effect on Collembola in the black soil region of China

The study investigates the impact of Bt-506 corn leaf litter on Collembola and decomposition rates, finding no significant effect of Bt protein but differences due to litter composition.

The anti-apoptotic proteins Bcl-2 and Bcl-xL suppress Beclin1/Atg6-mediated lethal autophagy in polyploid cells

The paper shows Bcl-2 and Bcl-xL reduce autophagic cell death in polyploid cells treated with Aurora-B kinase inhibitors, contributing to resistance to these drugs.

Direct Imaging of the circular chromosome of a live bacterium

This study directly images the circular chromosome of live E. coli cells, revealing its torus topology and dynamic structural features.