J. Chen

Mathematical modeling of mechanosensing and contact-dependent motility coordination in Myxococcus xanthus

This study develops a mathematical model to explain how Myxococcus xanthus uses mechanosensing during gliding motility to coordinate cell reversal frequency and multicellular pattern formation.

Modulating the epigenetic state promotes the reprogramming of transformed cells to pluripotency in a line-specific manner

This study identifies line-specific barriers to reprogramming transformed cells and shows that MEK inhibition can overcome some of these barriers by modulating the epigenetic state.

The 3-Dimensional Genome Drives the Evolution of Asymmetric Gene Duplicates via Enhancer Capture-Divergence

This paper shows that enhancer capture-divergence (ECD) is a significant evolutionary mechanism for asymmetric, distally duplicated genes, using Drosophila HP6/Umbrea as an example.

Proteomic Landscape of Human Spermatozoa: Optimized Extraction Method and Application

This study optimizes protein extraction methods for human sperm and investigates antibiotic effects on sperm proteome, finding increased concentration and malformed sperm with altered proteome expression.

Plasticity in centromere organization: Holocentromeres can consist of merely a few megabase-sized satellite arrays

The paper analyzes the holocentromere organization in Chionographis japonica, revealing that its holocentromeres consist of few, large satellite arrays and differ from other holocentric species.

The Cation/H+ exchanger OsCAX2 is involved in cadmium tolerance and accumulation through vacuolar sequestration in rice

This study identifies OsCAX2 as a key gene for cadmium tolerance and accumulation in rice by promoting vacuolar sequestration, reducing grain cadmium levels by over 70%.

Smart squirrels use a mortise-tenon structure to fix nuts on understory twigs

The paper describes how two species of flying squirrels in Hainan Island use a mortise-tenon structure to securely cache nuts on twigs to deter predation and ensure food supply.

Multiparameter stimulation mapping of signaling states in single pediatric immune cells reveals heightened tonic activation during puberty

The paper introduces HDStIM, an unsupervised method to analyze single-cell stimulation responses, revealing increased tonic activation in immune cells during puberty.

CryoEM reveals unprecedented binding site for NaV1.7 inhibitors enabling rational design of potent hybrid inhibitors

This study uses cryo-EM to reveal a new binding site for NaV1.7 inhibitors, enabling the design of hybrid inhibitors with improved selectivity and properties.

Peyers Patch B cells undergo cell death via neutrophil-released toxic DNA following sterile tissue injury

The paper shows that sterile tissue injury causes B cell death in Peyers patches via neutrophil-released toxic DNA, leading to tissue shrinkage and reduced secretory IgA.

ConstrastivePose: A contrastive learning approach for self-supervised feature engineering for pose estimation and behavorial classification of interacting animals

This paper introduces ConstrastivePose, a contrastive learning method for self-supervised feature engineering in pose estimation and behavioral classification of interacting animals, showing improved performance over handcrafted features.

Intertumoral lineage diversity and immunosuppressive transcriptional programs in well-differentiated gastroenteropancreatic neuroendocrine tumors

This study analyzes single-cell transcriptomes of gastroenteropancreatic neuroendocrine tumors to identify lineage diversity and immunosuppressive programs in tumor and immune cells.

QCR7 affects the virulence of Candida albicans and the uptake of multiple carbon sources present in different host niches

Proliferative Exhausted CD8 T Cells Exacerbate Long-lasting Anti-tumor Effects in Human Papillomavirus Positive Head and Neck Squamous Cell Carcinoma

The paper identifies a proliferative exhausted CD8+ T cell cluster in HPV-positive HNSCC that correlates with better patient survival and suggests potential therapeutic implications.

Mitoxantrone Targets Both Host and Bacteria to Overcome Vancomycin Resistance in Enterococcus faecalis

Mitoxantrone synergizes with vancomycin against vancomycin-resistant Enterococcus faecalis by direct antibiotic activity and enhancing host macrophage recruitment and bactericidal activity.

Conventional dendritic cells 2, the targeted antigen-presenting-cell, induces enhanced type 1 immune responses in mice immunized with CVC1302 in oil formulation

This study shows that CVC1302 in oil formulation enhances Th1 immune responses by targeting antigen and inflammatory monocytes to lymph node inter-follicular regions and promoting IL-12 production by cDC2.

Inferring time-aware models of cancer progression using Timed Hazard Networks

This paper introduces TimedHN, a method that infers oncogenetic graphs and pseudo-time orders from cancer data, outperforming existing methods on synthetic and breast cancer datasets.

Structural and Dynamic Insights Into α-Synuclein Dimer Conformations

The paper identifies a compact, stable dimeric conformation of α-synuclein that may promote dityrosine linkage and is implicated in Parkinson's disease.

Gene expression profile of the developing endosperm in durum wheat provides insight into starch biosynthesis

The paper generates a transcriptomics dataset of developing durum wheat endosperm to study starch biosynthesis and provides insights into gene expression patterns during grain development.

Protease inhibitor ASP enhances freezing tolerance by inhibiting protein degradation in Kumquat

A protease inhibitor from kumquat enhances freezing tolerance by stabilizing proteins through inhibition of non-specific protease degradation.

PIEZO1 regulates leader cell formation and cellular coordination during collective keratinocyte migration

This study investigates how PIEZO1 regulates leader cell formation and coordinated migration during keratinocyte wound healing, finding that PIEZO1 inhibits leader cell formation and disrupts coordinated directionality.

Development of an affinity-enhanced clinical candidate TCR targeting NY-ESO-1 with optimal potency and high specificity

This study develops a high-affinity, specific TCR targeting NY-ESO-1 through engineering and screening, showing efficacy in tumor models and approval for clinical trials.

An e-cigarette aerosol generation, animal exposure and toxicants quantification system to characterize in vivo nicotine kinetics in arterial and venous blood

This paper describes a system for generating and assessing e-cigarette aerosol exposure in animals, showing higher nicotine concentrations in arterial blood compared to venous blood.

PCLAF-DREAM Drives Alveolar Cell Plasticity for Lung Regeneration

This study identifies PCLAF-DREAM's role in alveolar cell plasticity during lung regeneration and shows a drug candidate can pharmacologically target this process to prevent fibrosis.

LINC01184 is highly expressed and functions as a tumor-promotive factor in hepatocellular carcinoma

This study identifies LINC01184 as a tumor-promotive factor in hepatocellular carcinoma, showing its overexpression correlates with poor patient outcomes and its role in promoting cell proliferation and migration.

The RNA m6A reader YTHDF1 promotes hematopoietic malignancy by maintaining oncogenic translation

This study identifies YTHDF1 as an oncogenic m6A reader promoting AML by enhancing oncogenic translation and shows tegaserod inhibits its function.

The plastidial protein MRC promotes starch granule initiation in wheat leaves but delays B-type granule initiation in the endosperm

This study identifies MRC's organ-specific roles in regulating starch granule initiation in wheat leaves and endosperm, showing it promotes leaf granules but delays endosperm B-type granule initiation.

Atypical peripheral actin band formation via overactivation of RhoA and Non-muscle myosin II in Mitofusin 2 deficient cells

This study shows that MFN2 deficiency leads to increased cytosolic Ca2+ and overactivation of RhoA and non-muscle myosin II, causing atypical peripheral actin band formation in mouse embryonic fibroblasts.

Intranasal delivery of NS1-deleted influenza virus vectored COVID-19 vaccine restrains the SARS-CoV-2 inflammatory response

This study evaluates an intranasal influenza-based vaccine against SARS-CoV-2 variants, showing it reduces inflammatory response and tissue damage through local immunity.

Spatially defined multicellular functional units in colorectal cancer revealed from single cell and spatial transcriptomics

The paper combines single cell and spatial transcriptomics to map spatial organization and functional interactions in colorectal cancer across species.