J. Chen

Micropolarity governs the structural organization of biomolecular condensates

The paper shows that micropolarity differences between subcompartments dictate the structural organization of biomolecular condensates, leading to layered structures and functional changes.

Experimental heatwaves and warming cause distinctive community responses through their interactions with a novel species

The paper examines how experimental heatwaves and warming affect community responses in a multi-trophic system, showing distinct impacts based on climate type and species interactions.

The immune receptor SNC1 monitors helper NLRs targeted by a bacterial effector

The paper shows that SNC1, an immune receptor, guards ADR1-L1 and ADR1-L2 from bacterial effector suppression, enabling plant immunity through sequence diversification and a layered defense system.

HCC-1 accelerates atherosclerosis by inducing endothelial cells and macrophages pyroptosis and serves as an early diagnostic biomarker

This study shows HCC-1 promotes atherosclerosis by inducing pyroptosis in endothelial cells and macrophages and suggests it as an early diagnostic biomarker.

A hierarchical strategy to decipher protein dynamics in vivo with chemical cross-linking mass spectrometry

This paper introduces a hierarchical strategy using CXMS and AlphaFold2 to analyze protein dynamics in vivo, focusing on IDPs and multi-domain proteins.

Dynamic phosphatase-recruitment controls B-cell selection and oncogenic signaling

This study identifies CD25 as a scaffold for phosphatases that regulate B-cell signaling and oncogenic processes, with opposing effects on B-cell malignancies and autoimmunity.

Targeted engagement of β-catenin-Ikaros complexes in refractory B-cell malignancies

This study identifies a unique vulnerability in B-cell malignancies where GSK3β inhibitors disrupt β-catenin-Ikaros complexes, leading to MYC repression and cell death.

Epigenetic modifications mediate cultivar-specific root development and metabolic adaptation to nitrogen availability in wheat

Structural and mechanistic insight into ribosomal ITS2 RNA processing by nuclease-kinase machinery

The paper reports structures of Las1-Grc3 complexes and identifies their role in pre-rRNA cleavage during ribosome biosynthesis.

MYC-driven increases in mitochondrial DNA copy number occur early and persist throughout prostatic cancer progression

The paper develops a method to spatially quantify mitochondrial DNA copy number in cancer tissues and finds increased mtDNAcn in prostate cancer progression, linked to MYC activity.

Multi-omics and Pharmacological Characterization of Patient-derived Glioma Cell Lines

This study characterizes 52 patient-derived glioma cell lines with whole-genome sequencing, RNA-seq, and drug response screening, identifying three subtypes and their drug sensitivities and tumorigenic potential.

Comprehensive Multi-omics Analysis Reveals the Core Role of Glycerophospholipid Metabolism in Rheumatoid Arthritis Development

This study identifies glycerophospholipid metabolism as a key factor in rheumatoid arthritis development through multi-omics analysis of gut microbiota, metabolites, and gene expression.

Avirulent ME49Δgra5 Protecting Hosts Against Toxoplasma gondii Infection and Breast Tumors

This paper shows that the gra5 knockout T. gondii strain ME49Δgra5 is avirulent, prevents cyst formation, and protects against T. gondii infection and breast tumor growth in mice.

Excess PrPC inhibits muscle cell differentiation via miRNA-enhanced liquid-liquid phase separation implicated in myopathy

The Alfin-like transcription factor GmAlfin09 regulates endoplasmic reticulum stress in soybean via a peroxidase GmPRDX6

This study identifies GmAlfin09 as a transcription factor that enhances ER stress resistance in soybean by upregulating GmPRDX6, which reduces ROS levels and maintains ER homeostasis.

The soil emergence-related transcription factor PIF3 regulates root penetration by interacting with the receptor kinase FER

This study shows that PIF3, a transcription factor, regulates root penetration in Arabidopsis by interacting with FER, a receptor kinase, and modulating mechanosensitive ion channels and root cap cell sloughing.

Structure and dynamics of the essential endogenous mycobacterial polyketide synthasePks13

This paper determines the structure and dynamics of the mycobacterial polyketide synthase Pks13 using cryoEM and complementary techniques, revealing intermediate states and substrate binding.

How PTEN mutations degrade function at the membrane and life expectancy of carriers of mutations in the human brain

This study investigates how PTEN mutations affect conformational dynamics and clinical outcomes, revealing differences in catalytic activity and life expectancy between neurodevelopmental disorder and cancer-related mutations.

Reprogramming Intrahepatic Cholangiocarcinoma Immune Microenvironment by Chemotherapy and CTLA-4 Blockade Enhances Anti-PD1 Therapy

This paper shows that combining chemotherapy with CTLA-4 blockade reprograms the immune microenvironment of intrahepatic cholangiocarcinoma, enhancing the effectiveness of anti-PD1 therapy.

Single-cell transcriptomic landscape deciphers novel olfactory neuroblastoma subtypes and intratumoral heterogeneity

This study uses single-cell RNA sequencing to identify novel subtypes and intratumoral heterogeneity in olfactory neuroblastoma.

Characterizing Mineral Ellipsoids in New Bone Formation at the Interface of Ti6Al4V Porous Implants

This paper characterizes mineral ellipsoid packing at the bone-implant interface of Ti6Al4V porous implants using microscopy techniques and identifies orientation shifts that may contribute to bone strengthening.

Graph-pMHC: Graph Neural Network Approach to MHC Class II Peptide Presentation and Antibody Immunogenicity

The paper introduces graph-pMHC, a graph neural network for predicting MHC Class II peptide presentation and improves antibody immunogenicity risk prediction.

Antimicrobial mitochondrial reactive oxygen species induction by lung epithelial metabolic reprogramming

The paper shows that CpG ODNs interact with mitochondrial VDAC1 to induce antimicrobial ROS in lung epithelial cells, offering a new therapeutic strategy for pneumonia without antibiotics.

Spike substitution T813S increases Sarbecovirus fusogenicity by enhancing the usage of TMPRSS2.

The paper identifies the T813S mutation in the S2 subunit of SARS-CoV Spike protein enhances fusogenicity by improving TMPRSS2 cleavage, increasing viral replication.

ATP-releasing SWELL1 channel in spinal microglia contributes to neuropathic pain

This study identifies VRAC as an ATP-releasing channel in microglia contributing to neuropathic pain and shows dicumarol inhibits it, reducing pain behaviors in mice.

ColMA/PEGDA Bioink for Digital Light Processing 3D Printing in Biomedical Engineering

This paper develops a collagen-based bioink for DLP 3D printing, achieving tunable mechanical properties and high-resolution structures suitable for biomedical applications.

Osseointegration of functionally-graded Ti6Al4V porous implants: Histology of the pore network

This study compares osseointegration of functionally-graded and uniform porous Ti6Al4V implants in rabbit tibiae, finding that smaller pores promote better bone volume and implant contact.

Human CCR6+ Th cells show both an extended stable gradient of Th17 activity and imprinted plasticity

The paper identifies an extended gradient of Th17 activity in human CCR6+ Th cells, showing both stable phenotypes and plasticity under different activation conditions.

Effects of nonantibiotic alternative growth promoter combinations on nutrient utilization, digestive enzyme activity, intestinal morphology, and cecal microflora of broilers

This study evaluates six nonantibiotic growth promoters in broilers, finding they improve nutrient utilization, intestinal morphology, and microbial composition compared to control and enramycin.

Label-free and high-throughput removal of residual undifferentiated cells from iPSC-derived spinal-cord progenitor cells

This study removes residual undifferentiated iPSCs from spinal-cord progenitor cells using size-based microfluidic separation, reducing OCT4-positive cells without affecting viability.