J. Chen

Multiomics reveal that silk fibroin and sericin differentially potentiate the paracrine functions of mesenchymal stem cells and enhance tissue regeneration

This study uses multiomics to show that silk fibroin and sericin enhance mesenchymal stem cell paracrine activity and tissue regeneration through distinct pathways.

Gene inversion triggered origination of brackish archaeal heterotrophs in the aftermath of the Cryogenian Snowball Earth

The paper traces the evolutionary origin of brackish archaea, showing gene rearrangements enabled their adaptation to coastal environments after the Cryogenian Snowball Earth.

A pan-variant mRNA-LNP T cell vaccine protects HLA transgenic mice from mortality after infection with SARS-CoV-2 Beta

A T cell vaccine based on conserved epitopes protects HLA transgenic mice from SARS-CoV-2 Beta variant mortality without inducing neutralizing antibodies.

LINC02428, a liver-specific long noncoding RNA suppresses hepatocellular carcinoma progression

This study identifies LINC02428 as a liver-specific lncRNA that suppresses hepatocellular carcinoma progression by inhibiting cell proliferation, migration, and inducing apoptosis.

Parallel use of pluripotent human stem cell lung and heart models provide new insights for treatment of SARS-CoV-2

The paper uses human pluripotent stem cell-derived lung and heart models to identify antiviral compounds with distinct profiles, highlighting the need for multi-organ testing in SARS-CoV-2 treatment.

Genetic, Clinical Underpinnings of Brain Change Along Two Neuroanatomical Dimensions of Clinically-defined Alzheimer's Disease

This study identifies two brain atrophy dimensions in Alzheimer's disease using Surreal-GAN and links them to genetic and clinical factors, revealing distinct pathological mechanisms.

Cancer cells communicate with macrophages to prevent T cell activation during development of cell cycle therapy resistance

The paper shows cancer cells in resistant tumors promote immune-suppressive macrophages, reducing T-cell activation, and suggests balancing cell cycle inhibition with immune activation for better therapy.

An ensemble of interconverting conformations of the elemental paused transcription complex creates regulatory options

This study defines an interconverting ensemble of ePEC states using cryo-EM and biochemical analysis, showing that ePECs occupy pre- or half-translocated states without always swiveling.

A widespread family of phage-inducible chromosomal islands only steals bacteriophage tails to spread in nature

The paper identifies a new family of phage-inducible chromosomal islands that produce small capsids using phage tails and spread without harming their helper phages.

Initial niche condition determines the aging speed and regenerative activity of quiescent cells

This study shows that initial niche conditions determine the aging speed and regenerative activity of quiescent fission yeast cells, with regenerative activity declining linearly before survivability.

WDFY4 deficiency in NOD mice abrogates autoimmune diabetes and insulitis

This study shows that WDFY4 deficiency in NOD mice prevents autoimmune diabetes by blocking CD8 T cell priming, while preserving CD4 T cell activation and islet infiltration.

Enhancer Reprogramming in Melanoma Immune Checkpoint Therapy Resistance

The paper identifies enhancer-based biomarkers of resistance to anti-PD-1 therapy in melanoma and suggests enhancer blockade combined with ICB as a potential strategy to improve treatment responses.

Wounding promotes root regeneration through a cell wall integrity sensor, the receptor kinase FERONIA

The paper identifies RALF33-FER as an early signaling module between wounding and root regeneration, interacting with TPL/TPRs to regulate regeneration-related genes.

DNp63 Regulates Homeostasis, Stemness, and Suppression of Inflammation in the Adult Epidermis

This study shows that DeltaNp63 is essential for maintaining epidermal homeostasis, stemness, and inflammation suppression in adult skin, with its loss causing psoriasis-like inflammation and impaired wound healing.

RBP45d is required for 5' splice site selection via binding to intronic U-rich elements and interaction with PRP39a in Arabidopsis thaliana

The study identifies RBP45d as a key regulator of 5' splice site selection in Arabidopsis by binding to intronic U-rich elements and interacting with PRP39a.

A rapid alkalinization factor-like peptide EaF82 impairs tapetum degeneration during pollen development through induced ATP deficiency

The paper identifies EaF82, a RALF-like peptide, which delays tapetum degeneration in Arabidopsis by reducing ATP levels through AKIN10 interaction, impairing pollen development.

Spike-specific CXCR3+ TFH cells play a dominant functional role in supporting antibody responses in SARS-CoV-2 infection and vaccination

This study identifies spike-specific CXCR3+ TFH cells as key drivers of long-term antibody responses in SARS-CoV-2 infection and vaccination.

Identification and functional prediction of sugar beet circRNAs involved in drought responses

This study identifies and functionally predicts sugar beet circRNAs involved in drought responses using deep sequencing and network analysis.

Oncogenic EFNA4 amplification promotes lung adenocarcinoma lymph node metastasis

This study identifies EFNA4 amplification as a driver of lung adenocarcinoma lymph node metastasis through genomic analysis and functional experiments.

Development of Equine Polyclonal Antibodies as a Broad-Spectrum Therapy Against SARS-CoV-2 Variants

This paper develops equine polyclonal antibodies that broadly neutralize major SARS-CoV-2 variants, showing high efficacy in vitro and ex vivo with low cost and potential for large-scale production.

Novel leaf-root coordination driven by leaf water storage tissues in mangroves

This study identifies a unique leaf-root coordination mechanism in mangroves driven by leaf water storage tissues, distinct from non-mangrove plants.

Mechanistic basis for targeting homologous recombination defective liver cancer via synthetic lethality

This study identifies a novel subtype of HRD in HBVHCC caused by CDW19S perturbation and shows it can be targeted therapeutically.

Contribution of Signaling Partner Association to Strigolactone Receptor Selectivity

This study uses molecular dynamics to show that ShHTL7 has enhanced MAX2 binding due to its T2-T3 helix structure, contributing to its higher signaling activity compared to other strigolactone receptors.

Dissecting the genetic basis of the heterosis of Y900, an elite super-hybrid rice

The paper identifies genetic and regulatory mechanisms underlying heterosis in the rice hybrid Y900 by analyzing genome and transcriptome data from its parental lines.

Effect of Histidine Covalent Modification on Strigolactone Receptor Activation and Selectivity

This study shows that covalent butenolide modification of histidine enhances strigolactone receptor activation, with greater effect in the parasitic ShHTL7 receptor.

Retaining pluripotency and exogenous mRNA introduction in planarian stem cell culture

This study develops methods to culture planarian neoblasts and deliver exogenous mRNAs, demonstrating retained pluripotency and improved yield.

Diversity and Evolution of Computationally Predicted T Cell Epitopes against Human Respiratory Syncytial Virus

This study computationally predicts T cell epitopes in RSV proteins and finds divergent epitope patterns between RSV-A and RSV-B strains, suggesting vaccine updates may be needed for RSV-B.

Inhibitory effects of GT0918 on acute lung injury and the molecular mechanisms of anti-inflammatory response

This study shows GT0918 reduces cytokine release and inflammation in COVID-19 by inhibiting NF-κB and activating NRF2, suggesting its potential for treating both mild and severe cases.

IFNA pathway drives the more aggressive phenotype of KRASG12D-mutant pancreatic ductal adenocarcinomas via IFNAR1/STAT3 activation

The paper shows that the IFNA pathway promotes aggressive KRASG12D-mutant pancreatic ductal adenocarcinomas through IFNAR1/STAT3 activation and identifies IFNAR1 inhibition as a potential therapeutic strategy.

Generation of functional posterior spinal motor neurons from hPSCs-derived human spinal cord neural progenitor cells

This study generates functional posterior spinal motor neurons from hPSCs-derived neural progenitor cells, demonstrating efficient differentiation and functional maturity.