S. Roy

Cellular dynamics under time-varying conditions

The paper proposes a temporal scaling model to explain how bacterial cells adjust their age distribution under changing environmental conditions using a time-invariant rule.

Conformational dynamics of C1r inhibitor proteins from Lyme disease and relapsing fever spirochetes

This study reports the crystal structure of FbpC and uses molecular dynamics simulations to show conformational dynamics in borrelial C1r inhibitors, revealing structural plasticity in their anti-complement activity.

Genetic consequences of effective and suboptimal dosing with mutagenic drugs in a hamster model of SARS-CoV-2 infection

This study examines the genetic effects of effective and suboptimal dosing of mutagenic drugs on SARS-CoV-2 in hamsters, finding dose-dependent mutational load and no drug resistance.

Hsp70/Hsp90 organizing protein (HOP) maintains CRAF kinase activity and regulates MAPK signaling by enhancing Hsp90-CRAF association

Identification of diverse antibiotic resistant bacteria in agricultural soil with H218O stable isotope probing and metagenomics

This study identifies antibiotic-resistant bacteria in agricultural soil using stable isotope probing and metagenomics, revealing diverse ARGs in heavy fractions.

The emergence of goblet inflammatory or ITGB6hi nasal progenitor cells determines age-associated SARS-CoV-2 pathogenesis

The study identifies age-related differences in nasal epithelial cell responses to SARS-CoV-2 infection, showing distinct progenitor cell dynamics in children and elderly.

Novel Peptide Inhibitor of Human Tumor Necrosis Factor-α has Antiarthritic Activity

The paper designs a peptide inhibitor of TNF-α that reduces inflammation and joint damage in arthritis models.

GEMC1 and MCIDAS interactions with SWI/SNF complexes regulate the multiciliated cell-specific transcriptional program

This study identifies distinct interactions of GEMC1 and MCIDAS with SWI/SNF subcomplexes in multiciliated cell differentiation and shows that these interactions are required for MCC-specific transcriptional regulation.

Distributed Compact Plasma Reactor Sterilization for Planetary Protection in Space Missions

This study demonstrates the effectiveness of the Active Plasma Sterilizer (APS) in achieving log reductions of pathogenic bacteria on various materials using cold plasma technology.

Discovery, Synthesis, and Optimization of 1,2,4-Triazolyl Pyridines Targeting Mycobacterium tuberculosis

This paper discovers and optimizes a new series of 1,2,4-triazolyl pyridines that inhibit Mycobacterium tuberculosis growth with nanomolar activity and favorable pharmacokinetics.

Phosphorylation of Gαi shapes canonical Gα(i)βγ/GPCR signaling

This study identifies phosphorylation sites on Gαi that modulate GPCR signaling by altering Gi activation and localization, revealing mechanisms of cross-talk between growth factor and chemokine signaling pathways.

A Rigid Parallel-Plate Artificial Placenta Oxygenator with a Hemocompatible Blood Flow Path

This study presents a rigid parallel-plate artificial placenta oxygenator with improved hemocompatibility, demonstrating favorable oxygen flux and low pressure drop in benchtop and pig models.

Tip-links serve as force-pass filter to fulfil the role of gating-springs

The paper investigates the mechanical behavior of tip-links in hearing, showing they act as low-force pass filters through slip-ideal-slip bond dynamics and their role in gating-springs.

The effect of environment on the evolution and proliferation of protocells of increasing complexity

This study develops a computational model to examine how environmental phases affect the evolution and proliferation of complex protocells containing ribozymes.

Rapid non-destructive method to phenotype stomatal traits

The paper develops a rapid non-destructive method to phenotype stomatal traits using imaging and machine learning, achieving high accuracy and efficiency.

Within-host diversity improves phylogenetic and transmission reconstruction of SARS-CoV-2 outbreaks

This study shows that incorporating within-host genetic diversity improves phylogenetic and transmission reconstruction of SARS-CoV-2 outbreaks.

HIV positive patients on antiretroviral therapy have an altered mucosal intestinal but not oral microbiome

This study compares the intestinal and oral microbiome composition and function between HIV-positive and uninfected individuals, finding significant intestinal changes but no oral differences.

The peptide GOLVEN10 controls nodule and lateral root organogenesis and positioning along the longitudinal root axis

The paper identifies GOLVEN10 peptide as a regulator of nodule and lateral root positioning and organogenesis in Medicago truncatula.

TCGADEPMAP -- Mapping Translational Dependencies and Synthetic Lethalities within The Cancer Genome Atlas

TCGADEPMAP maps translational tumor dependencies and synthetic lethality using TCGA data, identifying novel targets like PAPSS1/2 with clinical implications.

Functional substitutability of native herbivores by livestock for long-term soil carbon depends on microbial decomposers.

This study compares the effects of livestock and native herbivores on soil carbon in the Trans-Himalayan ecosystem, finding livestock reduce soil carbon stocks and microbial carbon use efficiency.

Experimental and mathematical models of intracellular calcium dynamics for evaluating combined anticancer effects of Afatinib and RP4010 in esophageal cancer

Nutrient and salt depletion synergistically boosts glucose metabolism in individual bacteria

This study shows that nutrient and salt depletion in E. coli increases glucose accumulation rates at the translational and posttranslational levels, challenging the view that growth rate alone reflects metabolic status.

Preclinical stage abundance and nuclear antigen reactivity of fecal Immunoglobulin A (IgA) varies among males and females of lupus-prone mouse models

The paper examines fecal IgA abundance and nuclear antigen reactivity in lupus-prone mouse models, finding gender and model-specific variations that correlate with future autoantibody levels.

Prostaglandin E1 as therapeutic molecule for Nephronophthisis and related ciliopathies

This study identifies PGE1 as a potential therapeutic for NPH-associated ciliopathies, showing it rescues ciliogenesis and improves kidney phenotypes in models.

Discovery of novel compounds as potent activators of Sirt3

This study identifies novel Sirt3 activators using DNA encoded library technology, showing potency comparable to Honokiol and atypical binding sites.

Development, Structure, and Mechanism of Synthetic Antibodies that Target Claudin and Clostridium perfringens Enterotoxin Complexes

This paper develops synthetic antibodies (sFabs) targeting claudin-4 and Clostridium perfringens enterotoxin (CpE) complexes, revealing their binding mechanisms and structural insights to inform therapeutic strategies.

Capturing a crucial 'disorder-to-order transition' at the heart of the coronavirus molecular pathology - triggered by highly persistent, interchangeable salt-bridges

The paper investigates the disorder-to-order transition in the SARS-CoV-2 Spike protein upon Furin binding, highlighting salt-bridge networks and their role in proteolytic cleavage efficiency.

Single-cell analysis resolves the genetic program of primary vascular system formation in hybrid poplar

The paper uses single-cell RNA-seq to map the genetic program of primary vascular development in hybrid poplar at single-cell resolution.

Denitrification in foraminifera has ancient origin and is complemented by associated bacteria

The paper shows denitrification genes are conserved in foraminifera and their microbiome complements the pathway, revealing an ancient origin of this trait in these organisms.

Loss of Zfp335 triggers cGAS/STING-dependent apoptosis of post-β selection pre-T cells

This study identifies Zfp335 as a transcription factor that regulates survival of post-β-selection DN4 thymocytes by suppressing cGAS/STING-dependent apoptosis.