W. Chen

Insect hormone PTTH regulates lifespan through temporal and spatial activation of NF-κB signaling during metamorphosis

This study shows that PTTH loss-of-function in Drosophila extends lifespan by repressing NF-κB signaling in oenocytes during metamorphosis.

Gut microbial genomes with paired isolates from China signify probiotic and cardiometabolic effects

The paper presents a new microbial reference set with paired isolates from China, showing probiotic and cardiometabolic effects on hosts.

A Stapled Peptide Inhibitor of METTL3-METTL14 for Cancer Therapy

This paper develops a stapled peptide inhibitor of METTL3-METTL14 that suppresses tumor growth by inhibiting m6A methylation and promoting METTL3 degradation.

Population genomic analyses reveal extensive genomic regions within selective sweeps associated with adaptation and demographic history of a wheat fungal pathogen

This study uses population genomic analyses to identify genomic regions under selection and demographic history of the wheat rust pathogen Pst, revealing adaptation mechanisms and population size changes linked to wheat domestication and agriculture.

Pancreatic islet α cell function and proliferation requires the arginine transporter SLC7A2

This study identifies SLC7A2 as essential for α cell proliferation and glucagon secretion, linking arginine transport to metabolic regulation and HbA1c variation.

Butyrate Protects against SARS-CoV-2-induced Tissue Damage in Golden Hamsters.

This study shows butyrate protects against SARS-CoV-2-induced tissue damage in golden hamsters by enhancing antiviral immunity and reducing oxidative stress.

Discovery of post-translationally modified self-peptides that promote hypertension

The paper identifies post-translationally modified self-peptides linked to hypertension using a combined computational and experimental approach.

Evolution of Shewanella oneidensis MR-1 in competition with Citrobacter freundii

This study examines how Shewanella oneidensis MR-1 evolves in competition with Citrobacter freundii An1 under different electron acceptor conditions.

Exploring Urban Street Green Perception from the Perspective of Combining GVI and NDVI: A Case Study of Zhongshan City, Guangdong Province

This study combines GVI and NDVI to analyze urban street greening in Zhongshan City, finding strong correlation and scale sensitivity, and proposes optimization strategies.

Combining Bacteriophage and Vancomycin is Efficacious Against MRSA biofilm-like Aggregates Formed in Synovial Fluid

This study shows that combining bacteriophage Remus and vancomycin effectively reduces MRSA biofilm-like aggregates in both in vitro and in vivo models.

Aging-associated Decline in Vascular Smooth Muscle Cell Mechanosensation is Mediated by Piezo1 Channel

This study shows that aging impairs vascular smooth muscle cell mechanosensation via Piezo1 hyperactivity, and inhibiting Piezo1 can alleviate vascular aging.

Mechanistic characterization of a Drosophila model of paraneoplastic nephrotic syndrome

This study identifies a mechanism by which gut tumors in Drosophila induce kidney dysfunction through Pvf1-mediated signaling.

Clostridium butyricum and Clostridium tyrobutyricum: angle or devil for Necrotizing enterocolitis?

This study compares the effects of Clostridium butyricum and Clostridium tyrobutyricum on Necrotizing enterocolitis in mice, finding that C. tyrobutyricum alleviates inflammation and improves intestinal barrier integrity, while C. butyricum worsens these conditions.

Surf4 deficiency reduces intestinal lipid absorption and secretion and decreases metabolism in mice

This study shows that intestinal Surf4 deficiency reduces lipid absorption, secretion, and metabolism in mice, leading to weight loss and altered lipid levels.

A conserved protein inhibitor brings under check the activity of RNase E in cyanobacteria

The paper identifies RebA as a conserved inhibitor of RNase E in cyanobacteria, showing it suppresses RNase E activity and affects cell morphology.

Immunometabolic rewiring in long COVID patients with chronic headache

This study analyzes multi-omics data from long COVID patients with chronic headache to identify immunometabolic changes associated with the condition.

Bovine milk glycoproteins inhibit SARS-CoV-2 and influenza virus co-infection

This study shows that galactosylated glycoproteins from bovine milk inhibit both SARS-CoV-2 and influenza virus by blocking their interaction with ACE2.

Continuous muscle, glial, epithelial, neuronal, and hemocyte cell lines for Drosophila research

The paper generates continuous cell lines for Drosophila muscle, glial, epithelial, neuronal, and hemocyte types using RasV12 activation and ecdysone differentiation.

Molecular Mechanocytometry Using Tension-activated Cell Tagging (TaCT)

The paper introduces TaCT, a method to fluorescently label cells based on molecular force through adhesion receptors, and demonstrates its use in fibroblasts and mouse platelets.

Identification of a key genetic factor governing arabinan utilization in the gut microbiome suggests a novel therapeutic target for constipation

The paper identifies the abfA cluster as a key genetic factor for arabinan utilization in gut microbiota, showing its therapeutic potential for constipation through improved gut motility and metabolite production.

Diversity and ecological function of urease-producing bacteria in the cultivation environment of Gracilariopsis lemaneiformis

This study isolates urease-producing bacteria from the cultivation environment of Gracilariopsis lemaneiformis and shows they enhance urea uptake and nitrogen assimilation by the macroalgae.

Cell Dynamic Mechanics Regulates Large-spatial Isotropic Matrix Modeling with Computational Simulations

The paper uses computational simulations to study how cell mechanics regulate isotropic collagen matrix modeling at large spatial scales, revealing key cellular mechanisms involved.

Chromosome-level genome assembly of Torreya grandis provides insights into the origin and evolution of gymnosperm-specific sciadonic acid biosynthesis

The paper presents a chromosome-level genome assembly of T. grandis and identifies genes responsible for gymnosperm-specific sciadonic acid biosynthesis.

Mechano-Cas12a Assisted Tension Sensor (MCATS) for Massively Amplified Cell Traction Force Measurements

MCATS detects cell-generated forces using CRISPR-Cas12a, showing drug effects on platelet forces and identifying platelet dysfunction after cardiopulmonary bypass.

Inhibiting a mRNA motif binding protein that mediates TGF-β1 upregulation of translation attenuates pulmonary fibrosis in mice

The paper identifies an mRNA motif regulated by TGF-β1 that enhances translation of NEU3, and shows that inhibiting the binding protein DDX3 reduces pulmonary fibrosis in mice.

Single-cell transcriptomics of the immune system in ME/CFS at baseline and following symptom provocation

This study uses single-cell RNA-seq to analyze immune cells in ME/CFS patients at baseline and after exercise, identifying dysregulated monocytes and platelet transcriptomes.

Advanced physiological maturation of iPSC-derived human cardiomyocytes using an algorithm-directed optimization of defined media components

This study develops a novel medium for iPSC-derived cardiomyocytes using differential evolution to enhance maturation, validated through multiomic analysis.

Horizontally transferred genes as RNA interference targets for aphid and whitefly control

This study identifies horizontally transferred genes (HTGs) in aphids and whiteflies as potential RNAi targets for pest control, showing they can be silenced without harming beneficial insects.

CryoFIB milling large tissue samples for cryo-electron tomography

This paper introduces a cryoFIB milling workflow for isolating objects of interest from large tissue samples, resulting in thin lamellae suitable for cryo-electron tomography.

Changes in lung sialidases in male and female mice after bleomycin aspiration

This study examines changes in lung sialidase expression in male and female mice after bleomycin aspiration, finding differential expression patterns and fibrosis association with NEU3.