X. Yang

Simultaneous multimodal three-photon and optical coherence microscopy of the mouse brain in the 1700 nm optical window in vivo

This paper demonstrates a multimodal imaging system combining three-photon microscopy and optical coherence microscopy in vivo for deep brain imaging with high resolution.

Genome analyses reveal the secondary metabolites potentially influence the geographical distribution of Fusarium pseudograminearum populations

This study analyzes genomes of Fusarium pseudograminearum strains to show that secondary metabolite synthesis genes influence their geographical distribution and toxin production.

In Vivo Antiviral Efficacy of LCTG-002, a Pooled, Purified Human Milk Secretory IgA product, Against SARS-CoV-2 in a Murine Model of COVID-19

This study evaluates LCTG-002, a purified human milk sIgA product, showing it effectively reduces SARS-CoV-2 viral burden in mice.

HSPA8-mediated stability of the CLPP protein regulates mitochondrial autophagy in cisplatin-resistant ovarian cancer cells

This study identifies HSPA8-mediated CLPP stability as a regulator of mitochondrial autophagy and cisplatin resistance in ovarian cancer cells.

Chemotherapeutic regulation of the ROS/MondoA-dependent TXNIP/GDF15 axis; and derivation of a new organoid metric as a predictive biomarker

The paper identifies chemotherapy-induced TXNIP as a negative regulator of GDF15 in CRC, showing its potential as a prognostic biomarker through organoid models.

Molecular basis of Gabija anti-phage supramolecular assemblies

This study reveals the structure and function of the Gabija anti-phage system, showing GajA forms tetramers and GajAB forms octamers, with GajB enhancing DNA cleavage activity.

Fungal-bacteria interactions provide shelter for bacteria in Caesarean section scar diverticulum

The paper investigates fungal-bacterial interactions in CSD, finding that fungal species alter bacterial abundance through metabolites, contributing to dysbiosis.

CD4+ T cell senescence is associated with reduced reactogenicity in severe/critical COVID-19

The paper finds that higher levels of CD4+ T cell senescence in severe/critical COVID-19 patients correlate with reduced antibody responses and worse survival, especially in breakthrough infections.

Dynamic simulations of feeding and respiration of the early Cambrian periderm-bearing cnidarian polyps

This study simulates the feeding and respiration of early Cambrian cnidarian polyps using CFD to show how muscle contractions drive water flow, supporting hypotheses about ancestral medusozoan behavior.

The transcriptional response in mosquitoes distinguishes between fungi and bacteria but not Gram types

This study compares the transcriptional responses of mosquitoes to different pathogens and finds that they distinguish between fungi and bacteria but not Gram types.

A 3D microtumour system that faithfully represents ovarian cancer minimal residual disease

This paper develops a 3D microtumour system that mimics ovarian cancer minimal residual disease, showing it responds to chemotherapy and reflects molecular signatures of MRD.

MKP1 promotes nonalcoholic steatohepatitis by suppressing AMPK activity through LKB1 nuclear retention

This study shows MKP1 suppresses AMPK activity via LKB1 nuclear retention, promoting NASH by inducing hepatocyte death and inflammation.

Structural insights into dual-antagonize mechanism of AB928 on adenosine A2 receptors

This study determines the crystal structures of A2AR with AB928 and 2-118, revealing distinct binding modes on A2AR and A2BR that explain AB928's dual-antagonistic properties.

Guild-level response of the gut microbiota to isocaloric time-restricted feeding in high-fat diet-fed mice

This study shows that time-restricted feeding alters gut microbiota guilds, which are linked to metabolic improvements in high-fat diet-fed mice.

When is an auxotroph not an auxotroph: how budding yeast lacking MET17 collectively overcome their metabolic defect

The paper shows that met17 mutants in S. cerevisiae can grow on sulfate at high cell densities due to hydrogen sulfide accumulation and the role of Hsu1 in sulfide assimilation.

Optimization of 3-Cyano-7-cyclopropylamino-pyrazolopyrimidines Toward the Development of an In Vivo Chemical Probe for CSNK2

The paper develops analogs of SGC-CK2-1 to improve pharmacokinetic properties in mice by inhibiting GST and P450 enzymes through co-dosing protocols.

Evolutionary analysis of conserved non-coding elements subsequent to whole-genome duplication in opium poppy

This study analyzes the evolutionary patterns of regulatory and coding sequences in opium poppy following whole-genome duplication, showing rapid regulatory element evolution contributes to new phenotypes.

ZBP1-mediated macrophage necroptosis inhibits ASFV replication

This study identifies ZBP1-mediated macrophage necroptosis as a mechanism that inhibits ASFV replication by promoting proinflammatory cytokine release.

Amphiphilic particle-stabilized nanoliter droplet reactors with a multi-modal portable reader for distributive biomarker quantification

This paper develops a portable droplet reactor system for biomarker quantification in resource-limited settings, achieving low detection limits and comparable accuracy to ELISA.

Functional analysis of Salix purpurea genes support roles for ARR17 and GATA15 as master regulators of sex determination

This study functionally characterizes candidate sex determination genes in Salix purpurea using Arabidopsis, supporting ARR17 and GATA15 as master regulators and identifying downstream transcription factors.

Discovery and Engineering of the L-Threonine Aldolase from Neptunomonas Marine for Efficient Synthesis of β-Hydroxy-α-Amino Acids via C-C Formation

This paper discovers and engineers an L-threonine aldolase from Neptunomonas marine to efficiently synthesize β-hydroxy-α-amino acids with high diastereoselectivity.

Kaposi's sarcoma-associated herpesvirus glycoprotein K8.1 is critical for infection in a cell-specific manner and functions at the attachment step on keratinocytes

This study shows K8.1 is critical for KSHV infection in epithelial cells but not in B cells, functioning at the attachment step.

Ketogenic diet therapy for pediatric epilepsy is associated with alterations in the human gut microbiome that confer seizure resistance in mice

This study shows that the ketogenic diet alters the gut microbiome in children with epilepsy, and transferring these microbes to mice increases seizure resistance.

Modification of social cheating facilitates the stabilization and chronic infection of polymorphic Pseudomonas aeruginosa population

The paper shows that evolution in Pseudomonas aeruginosa populations selects for cheater mutants that modify social cooperation to stabilize chronic infections and reduce host immune response.

Unfolded Protein Response Factor ATF6 Augments T Helper Cell Responses and Promotes Mixed Granulocytic Airway Inflammation

This study shows ATF6 enhances TH2 and TH17 cell responses and contributes to mixed granulocytic airway inflammation, suggesting ATF6 inhibition as a potential therapy for steroid-resistant asthma.

Mass-immigration shapes the antibiotic resistome of wastewater treatment plants

The paper monitors antibiotic resistance genes in wastewater treatment plants and finds that mass-immigration of bacteria and ARGs from upstream units shapes ARG communities, with stochastic processes dominating their assembly.

Development of Cell Permeable NanoBRET Probes for the Measurement of PLK1 Target Engagement in Live Cells

The paper develops a NanoBRET probe to measure PLK1 target engagement in live cells and evaluates its use with known PLK inhibitors.

Redefinition of archetypal phytoplankton-associated bacteria taxa based on globally distributed dinoflagellates and diatoms

The paper redefines phytoplankton-associated bacterial taxa at the genus level using data from diatoms and dinoflagellates, identifying core genera and their ecological roles in the phycosphere.

Two teosintes made modern maize

This study clarifies the origin of modern maize by showing it resulted from an ancient admixture between domesticated maize and Zea mays ssp. mexicana around 5300 years ago, contributing to genetic and phenotypic diversity.

Homocysteine accelerates hepatocyte autophagy by upregulation of TFEB via DNMT3b-mediated DNA hypomethylation

This study shows homocysteine increases hepatocyte autophagy by upregulating TFEB through DNMT3b-mediated DNA hypomethylation of the TFEB promoter.