Z. Lu

Transcriptomics analysis reveals intracellular mutual regulation of coral-zooxanthella holobionts

The paper analyzes transcriptomes and small RNAs of corals and their symbionts to reveal mutual gene regulation mechanisms and miRNA roles in host-symbiont interactions.

An open-access volume electron microscopy atlas of whole cells and tissues

The paper presents a 3D electron microscopy atlas of whole cells and tissues with high resolution and large volume, enabling new biological insights.

Durability of SARS-CoV-2-specific T cell responses at 12-months post-infection

This study examines SARS-CoV-2-specific T cell responses 12-months post-infection, finding durable responses with higher frequencies in those with severe acute illness.

Distinct Colon Mucosa Microbiomes associated with Tubular Adenomas and Serrated Polyps

This study compares colon mucosa microbiomes in individuals with tubular adenomas, serrated polyps, and no polyps, finding distinct microbial compositions associated with each condition.

3D observation of large-scale subcellular dynamics in vivo at the millisecond scale

This paper introduces a method to observe 3D subcellular dynamics in vivo at high resolution and speed, demonstrating its application in various biological systems.

Kaposi's Sarcoma-associated Herpesvirus vFLIP Promotes MEndT to Generate Hybrid M/E State for Tumorigenesis

This study shows KSHV infection of MSCs drives MEndT to generate hybrid M/E state cells, which are tumorigenic and recapitulate KS features, with vFLIP as a key regulator.

A spike-ferritin nanoparticle vaccine induces robust innate immune activity and drives polyfunctional SARS-CoV-2-specific T cells

This study evaluates a spike-ferritin nanoparticle vaccine with adjuvants, showing enhanced T cell responses and cross-reactivity against SARS-CoV and other coronaviruses.

Kaposi's Sarcoma-associated Herpesvirus Promotes Mesenchymal-to-Endothelial Transition by Resolving the Bivalent Chromatin of PROX1 Gene

This study shows KSHV resolves the bivalent chromatin of PROX1 to activate its expression, promoting MEndT and tumorigenic features in MSCs.

Differential variation of NSCs in root branch orders of Fraxinus mandshurica Rupr. seedlings across different drought intensities and soil substrates

The paper examines how non-structural carbohydrates (NSCs) and fine root traits vary across root branch orders in Fraxinus mandshurica seedlings under different drought and soil conditions.

Modulating the voltage sensor of a cardiac potassium channel shows antiarrhythmic effects

This study identifies C28 as a compound that modulates IKs channel voltage sensor activation, reversing drug-induced APD prolongation without affecting normal APD.

Soil causes gut microbiota to flourish and total serum IgE levels to decrease in mice

The study shows that soil intake in mice increases gut microbial diversity and reduces serum IgE levels, suggesting potential prebiotic effects.

Human gut Faecalibacterium prausnitzii deploy a highly efficient conserved system to cross-feed on β-mannan-derived oligosaccharides

This study identifies a conserved system in Faecalibacterium prausnitzii that enables efficient cross-feeding on β-mannan-derived oligosaccharides, enhancing butyrate production in the human gut.

The jasmine (Jasminum sambac) genome and flower fragrances

This study presents the first de novo genome of Jasminum sambac and identifies gene clusters and pathways involved in flower fragrance biosynthesis.

Computational optical sectioning by phase-space imaging with an incoherent multiscale scattering model

This paper introduces a computational method for optical sectioning using phase-space imaging with an incoherent multiscale scattering model, achieving improved signal-to-background ratio in biological samples.

A Mycobacterium tuberculosis effector protein attacks host innate immunity by acting as an unusual ubiquitinating enzyme

This paper shows that Mtb PknG acts as an unusual ubiquitinating enzyme by promoting ubiquitination of TRAF2 and TAK1 to suppress host innate immunity.

Development of non-transgenic glyphosate tolerant wheat by TILLING

This study develops glyphosate-tolerant wheat using TILLING to combine T102I and P106S mutations in the EPSPS gene, resulting in substantial herbicide tolerance.

Cis-regulatory elements within TEs can influence expression of nearby maize genes

The paper identifies TE insertions that influence gene expression in maize by disrupting or carrying accessible chromatin regions, showing TEs can create novel regulatory elements.

Multiple expression assessments of ACE2 and TMPRSS2 SARS-CoV-2 entry molecules in the urinary tract and their associations with clinical manifestations of COVID-19

YTHDF1 drives intestinal immune response against bacterial infection

This study identifies YTHDF1 as a key regulator of intestinal immune responses against bacterial infection by modulating TRAF6 mRNA translation through m6A methylation.

Co-evolution of Eukaryotic-like Vps4 and ESCRT-III Subunits in the Asgard Archaea

This study shows that Asgard archaea possess ESCRT complexes with eukaryotic-like structural and functional features, suggesting they are evolutionary precursors to eukaryotic ESCRTs.

Topsentinol L Trisulfate, a new Marine Natural Product, that Targets Basal-like and Claudin-low Breast Cancers

This study identifies topsentinol L trisulfate as a compound effective against Basal-like and Claudin-low breast cancers by inhibiting AMPK and CHK1.

Large-scale RNAi screening uncovers new therapeutic targets in the human parasite Schistosoma mansoni

This study performs a large-scale RNAi screen in Schistosoma mansoni to identify therapeutic targets, finding genes involved in neuromuscular function, tissue integrity, and parasite survival.

Structural and Functional NIR-II Fluorescence Bioimaging in Urinary System via Clinically Approved Dye Methylene Blue

This study uses methylene blue for NIR-II fluorescence imaging to enable structural and functional imaging of the urinary system in vivo and preclinical renal function assessment.

Catabolism of 3-hydroxypyridine by Ensifer adhaerens HP1: a novel four-component gene encoding 3-hydroxypyridine dehydrogenase HpdA catalyzes the first step of biodegradation

This study identifies a four-component dehydrogenase gene cluster responsible for 3-hydroxypyridine degradation in Ensifer adhaerens HP1.

Geldanamycin inhibits Jumonji histone lysine demethylase KDM4 and targets chimeric transcription factor PAX3-FOXO1

This study identifies geldanamycin and its analog 17-DMAG as dual KDM/Hsp90 inhibitors effective against PAX3-FOXO1-driven rhabdomyosarcoma.

Behaviour and cold hardiness of the purple stem borer in winter, colonizing more northerly latitudes

This study examines the overwintering behavior and cold hardiness of the purple stem borer in its newly colonized northern range, identifying its survival strategies and potential distribution limits.

Parallel Concerted Evolution of Ribosomal Protein Genes in Fungi and Its Adaptive Significance

This study investigates the duplication and maintenance of ribosomal protein genes in fungi, finding parallel concerted evolution and adaptive advantages in sugar-rich environments.

Clonal evaluation of early onset prostate cancer by expression profiling of ERG, SPINK1, ETV1, and ETV4 on whole mount radical prostatectomy tissue

New mechanism-based inhibitors of aspartate transcarbamoylase for anticancer drug development

This study identifies new ATCase inhibitors by targeting a previously unknown regulatory region and active site, showing strong anticancer effects in cell lines and xenograft models.

Century long fertilization reduces stochasticity controlling grassland microbial community succession

This study examines how century-long fertilization affects microbial community succession and assembly mechanisms in grassland soils.