MicroRNA in disease regulation

The landscape of microRNA interactions annotation: analysis of three rare disorders as case study

The paper analyzes microRNA interactions in three rare disorders to assess data availability and annotation consistency across databases.

Characterisation of the in-vivo miRNA landscape in Drosophila ribonuclease mutants reveals Pacman mediated regulation of the highly conserved let-7 cluster during apoptotic processes

The paper characterizes miRNA expression in Drosophila wing imaginal discs and shows Pacman regulates the let-7 cluster, affecting apoptosis.

Comprehensive structural and interactome analysis reveals novel interactions and protein binding sites in miR-675: a non-coding RNA critically involved in multiple diseases

This study identifies the structure and interactome of miR-675, revealing novel protein binding sites and interactions that may serve as therapeutic targets for diseases.

CRISPR Activation/Inhibition Experiments Reveal that Expression of Intronic MicroRNA miR-335 Depends on the Promoter Activity of its Host Gene Mest

Modeling neurodevelopmental disorder-associated hAGO1 mutations in C. elegans Argonaute ALG-1

The paper models hAGO1 mutations in C. elegans to study their impact on miRNA function and gene expression, revealing allele-specific disruptions in miRNA profiles and gene regulation.

Delta40p53 plays a distinct regulatory role in maintaining cellular homeostasis by controlling SGSH expression via miR-4651-5p

The paper identifies a novel regulatory axis involving Delta40p53, miR-4671-5p, and SGSH that influences cell cycle progression and cancer outcomes.

MicroRNA-423-5p Mediates Cocaine-Induced Smooth Muscle Cell Contraction by Targeting Cacna2d2

This study identifies miR-423-5p as a regulator of cocaine-induced smooth muscle cell contraction by targeting Cacna2d2, leading to increased intracellular calcium and contractility.

Reassessing the abundance of miRNAs in the human pancreas and rodent cell lines and its implication

The paper reassesses miRNA abundance in human pancreas and rodent cell lines, finding miR-148a-3p and miR-7-5p are equally abundant in islets, challenging the previous notion of miR-375-3p as the dominant miRNA.

Experimental alteration of the microRNA profile of the mouse embryo: heritable phenotypes in the adult

The paper experimentally alters miRNA profiles in mouse embryos, leading to heritable phenotypes and behavioral changes resembling ASD features.

Transcriptome-wide analysis of microRNA-mRNA correlations in unperturbed tissue transcriptomes identifies microRNA targeting determinants.

The paper analyzes microRNA-mRNA correlations in tissue transcriptomes to identify targeting determinants and provides a bioinformatic tool for predicting interactions.

The Integrator complex regulates microRNA abundance through RISC loading

This study shows that the Integrator complex is essential for miRNA abundance by facilitating their loading into RISC.

Pan-Cancer Biomarker miR-151a Regulates p21 Partially Through p53

This study identifies miR-151a as a regulator of the cell cycle through p53/p21, showing its dual strands affect p53 differently and linking miR-151a expression to poor survival in tumors.

Differential co-expression network analysis with DCoNA reveals isomiR targeting aberrations in prostate cancer

DCoNA identifies differential co-expression networks in prostate cancer, revealing isomiR targeting aberrations and a cancer-specific role for hsa-miR-93-5p.

miRinGO: Prediction of biological processes indirectly targeted by human microRNAs

The paper introduces miRinGO, an R Shiny application that improves miRNA-GO term association prediction by considering indirectly targeted genes, outperforming existing methods.

Defining the contribution of microRNA-specific slicing Argonautes in animals

This study shows that slicing activity of microRNA-specific Argonautes in C. elegans affects miRNA levels and animal fitness under specific conditions.

MicroRNA-mRNA networks are dysregulated in opioid use disorder postmortem brain: further evidence for opioid-induced neurovascular alterations

The paper analyzes miRNA-mRNA networks in postmortem brain and blood samples from opioid use disorder patients, identifying dysregulated pathways and potential therapeutic targets.

MicroRNA-eQTLs in the developing human neocortex link miR-4707-3p expression to brain size

The paper identifies miRNA-eQTLs in human neocortical tissue, linking miR-4707-3p expression to brain size and educational attainment through colocalization with GWAS data.

A conserved sequence in Drosophila Argonaute1 mRNA contributes to stress response via inducing miR-999 degradation

The paper identifies a conserved sequence in Drosophila Argonaute1 mRNA that induces miR-999 degradation, contributing to stress response.

Regulatory effects of miRNA-19a on MAD2 expression and tumorigenesis in gastric cancer.

This study identifies miR-19a as a regulator of MAD2 in gastric cancer, showing its role in reducing cell migration, invasion, and promoting apoptosis when combined with mitotic checkpoint drugs.

Common signatures of differential microRNA expression in Parkinson's and Alzheimer's disease brains

The paper assesses differential microRNA expression in Parkinson's and Alzheimer's disease brains, identifying shared miRNAs with potential pathogenic roles.

Identification of plant-derived microRNAs in human kidney

The paper identifies plant-derived microRNAs in human kidney transplant patients and links three miRNAs to immune rejection.

MicroRNA binding site variation is enriched inpsychiatric disorders

The paper identifies enrichment of miRNA binding site variants in psychiatric disorders and other complex traits, suggesting their functional role in disease mechanisms.

miR2Trait: an integrated resource for investigating miRNA-disease associations

miR2Trait integrates miRNA-disease associations from two databases, offering a detailed resource for analyzing miRNA enrichment in diseases and disease-related miRNA profiles.

Diagnosis of type 2 Diabetes Mellitus (T2DM) using Paired microRNAs

This study identifies paired microRNAs as more effective biomarkers for diagnosing type 2 diabetes mellitus than single microRNAs.

Inferring microRNA regulation: A proteome perspective

The paper predicts miRNA-regulated genes using a protein-based machine learning framework, showing better performance than genomic approaches and identifying exceptions like GPCRs.

Differential microRNA expression analyses across two brain regions in Alzheimer's disease

The paper identifies differentially expressed miRNAs in two brain regions of Alzheimer's patients using qPCR and RNA-seq, highlighting potential targets involved in AD pathogenesis.

Paradoxical tumor suppressive role of the musculoaponeurotic fibrosarcoma gene in colorectal cancer

The paper investigates the tumor-suppressive role of c-MAF in colorectal cancer by analyzing its expression and effects in mouse models and human samples.

RNA Immunoprecipitation and Sequencing of Isolated RNAs (RIP-SIR) Identifies Endogenous miRNA-Target Interactions

The paper introduces RIP-SIR, a method to identify endogenous miRNA-target interactions across tissues and cell types.

agoTRIBE detects miRNA-target interactions transcriptome-wide in single cells

agoTRIBE identifies miRNA-target interactions in single cells using a fusion protein approach, revealing differential targeting across the cell cycle.

Synaptosome microRNAs regulate synapse functions in Alzheimer's disease

The paper compares miRNA expression in synaptosomes and cytosol from AD and control brains, identifying differentially expressed miRNAs and their potential roles in synapse function.