MicroRNA in disease regulation

Feedback between a retinoid-related nuclear receptor and the let-7 microRNAs controls the pace and number of molting cycles in C. elegans.

The paper identifies a feedback loop between NHR-23 and let-7 microRNAs that regulates molting cycles in C. elegans by controlling cycle frequency and number.

Differential Regulation Analysis Quantifies miRNA Regulatory Roles And Context-Specific Targets

The paper introduces a method to analyze differential miRNA regulation across multiple groups, identifying context-specific targets in immune cells and cancer subtypes.

hnRNPA1/2 homolog hrpa-1 coordinates with miRNAs to regulate gene expression during C. elegans development.

The paper shows HRPA-1 interacts with miRNAs and miRISC components in C. elegans, affecting miRNA function and developmental timing.

Haemolysis detection in microRNA-seq from clinical plasma samples

This paper identifies a 20-miRNA signature to detect haemolysis in microRNA-seq data from clinical plasma samples.

miR-34a negatively regulates cell cycle factor Cdt2/DTL in HPV infected Cervical Cancer Cells

This study shows miR-34a regulates Cdt2/DTL by targeting HPV E6 in cervical cancer cells, leading to reduced proliferation and increased stability of oncosuppressors.

miR targetome of primary human keratinocytes reveals a function for non-conserved binding sites

The paper identifies miR targetomes in primary human keratinocytes, showing that non-conserved binding sites contribute to mRNA repression during differentiation.

Expression Microdissection for use in qPCR based analysis of miRNA in a single cell type

The paper optimizes an expression microdissection method to improve miRNA yield and in vivo cell-type specificity for qPCR analysis.

A Deep Learning Method for MiRNA/IsomiR Target Detection

DMISO improves miRNA/isomiR target prediction by incorporating deep learning and isomiR-mRNA interaction features, achieving high precision and recall.

Epigenetic alterations in gut and brain of adult rats after oral administration of miR-320-3p and miR-375-3p at mid-lactation, and preventive potential of miR-320-3p on early weaning stress.

This study examines the effects of oral miR-320-3p and miR-375-3p delivery on gut and brain development in rats, showing miR-320-3p's potential to mitigate early weaning stress.

miRNAs Copy Number Variations repertoire as hallmark indicator of cancer species predisposition

The paper identifies miRNA copy number variations as a marker for cancer predisposition across species, showing they can distinguish cancer-prone from cancer-resistant organisms.

dbDEMC 3.0: Functional Exploration of Differentially Expressed miRNAs in Cancers of Human and Model Organisms

dbDEMC 3.0 updates a database of differentially expressed miRNAs in human and model organism cancers, expanding data entries and integrating functional annotations.

PACeR: a bioinformatic pipeline for the analysis of chimeric RNA-seq data

PACeR is a bioinformatic pipeline for analyzing chimeric RNA-seq data, providing tools for read processing, alignment, peak calling, and motif analysis.

A rationalized definition of general tumor suppressor microRNAs excludes miR-34a

The paper defines tumor suppressor microRNAs requiring genetic/epigenetic inactivation and anti-tumorigenic activity, finding miR-34a does not meet these criteria.

Molecular basis of indispensable accuracy of mammalian miRNA biogenesis

This study identifies the DExD/H helicase domain of Dicer as critical for accurate miRNA biogenesis, showing its role in substrate recognition, cleavage, and strand selection in mammals.

Profiling of circulating chromosome 21-encoded microRNAs, miR-155 and Let-7c, in Down Syndrome People

This study examines miR-155 and Let-7c expression in Down syndrome individuals and finds Let-7c overexpression linked to early cognitive impairment, while miR-155 correlates with lipid metabolism changes in adults.

A computational modeling of primary-microRNA expression

This study models pri-miRNA expression across 1829 cell types and tissues by associating them with mRNAs that reflect their expression patterns.

Critical contribution of 3' non-seed base pairing to the in vivo function of the evolutionarily conserved let-7a microRNA

This study investigates the in vivo role of the 3' non-seed region in let-7a microRNA, showing its importance in target repression and distinguishing let-7a from its paralogs.

SPOROS: A pipeline to analyze DISE/6mer seed toxicity

SPOROS is a pipeline that analyzes 6mer seed toxicity in small RNA sequencing data by focusing on the seed region of sRNAs bound to RISC.

DraculR: A web based application for in silico haemolysis detection in high throughput small RNA sequencing data

DraculR detects haemolysis contamination in small RNA sequencing data by calculating a haemolysis metric from microRNA expression data.

Single-molecule imaging of microRNA-mediated gene silencing in cells

This study uses single-molecule imaging to visualize miRNA-mediated gene silencing in cells, revealing miRNAs bind to translated mRNAs and induce repression and decay within 30-60 minutes.

New features of micro-RNA regulation of mRNA translation and stability revealed by expression of targeted or not targeted reporter genes

The paper investigates miRNA regulation of mRNA translation and stability using reporter genes in human cancer cells, revealing miRNA-specific effects and interactions between targeted and non-targeted transcripts.

microRNA-138 controls hippocampal interneuron function and short-term memory

This study identifies miR-138-5p as a regulator of short-term memory and inhibitory synaptic transmission in hippocampal interneurons, with implications for schizophrenia.

Flexible pri-miRNA structures enable tunable production of 5' isomiRs

The paper shows that flexible pri-miRNA structures enable the production of 5' isomiRs through alternative Drosha cleavage, influenced by RNA-binding proteins in cancer.

scanMiR: a biochemically-based toolkit for versatile and efficient microRNA target prediction

scanMiR predicts microRNA targets using a biochemical model and k-mer affinity, offering tools for binding site scanning, affinity estimation, and repression prediction.

Scalable and deep profiling of mRNA targets for individual microRNAs with chimeric eCLIP

This paper introduces chimeric eCLIP, a method to efficiently profile miRNA:mRNA interactions at scale, showing significant improvements in recovery and specificity.

miR-9a regulates levels of both rhomboid mRNA and protein in the early Drosophila melanogaster embryo

This study shows that miR-9a regulates rhomboid mRNA and protein levels in Drosophila embryos by promoting mRNA degradation and inhibiting translation.

Structure of the RPAP3:TRBP interaction reveals an involvement of the HSP90/R2TP chaperone complex in dsRNA pathways

The paper identifies the RPAP3-TRBP interaction and shows the HSP90/R2TP chaperone complex's role in dsRNA pathways by binding TRBP and affecting AGO and Dicer function.

Endogenous pancreatic microRNAs differentially target the Delta, Omicron, and Wuhan SARS-CoV-2 genomes to upregulate the Diabetes-associated genes

The paper investigates how endogenous pancreatic microRNAs differentially target SARS-CoV-2 variants (Delta, Omicron, Wuhan) and upregulate diabetes-associated genes despite UTR mutations.

Small RNA-sequencing for Analysis of Circulating miRNAs: Benchmark Study

This study benchmarks small RNA-sequencing methods for miRNA quantification in biofluids, finding no single method outperforms others and highlighting protocol-specific biases.

A nuclear function for an oncogenic microRNA as a modulator of snRNA and splicing

The paper shows miR-10b interacts with U6 snRNA, altering splicing and affecting cell viability through changes in CDC42 isoforms and levels.