Gut microbiota and health

Adherence to Lifes Essential 8 Enhances Gut Microbiota Diversity and Cognitive Performance

This study shows that better adherence to LE8 metrics improves gut microbiota diversity and cognitive performance in the Framingham Heart Study participants.

Discovery, functionality and global dynamics of Bifidobacterium longum subsp. nexti : a novel starch-degrading subspecies in the infant gut

The paper identifies a novel subspecies of Bifidobacterium longum, BL. nexti, in infant gut microbiomes, showing its association with formula feeding and vertical transmission.

Antibiotic-induced microbiota depletion impairs the pro-regenerative response to a biological scaffold in mice

This study shows antibiotic-induced microbiota depletion in mice impairs the pro-regenerative immune response to a biological scaffold, reducing myocyte regeneration and increasing fibrosis.

Eukaryotic composition across seasons and social groups in the gut microbiota of wild baboons

The paper characterizes eukaryotic diversity in wild baboon gut microbiomes and finds social group membership explains some variation, but season, age, and sex do not.

Trends in Machine Learning and Feature Selection Stability for Human Gut Microbiome (Shotgun Metagenomics) and Metabolomics Matched Datasets

This study evaluates machine learning algorithms and feature selection stability in multi-omics microbiome datasets, finding that nonlinear models and multi-omics integration improve predictive performance and reproducibility.

Signed, Sealed, Delivered: A Generalizable Model for Probiotic Delivery and Metabolism in the Gut

The paper introduces a model for probiotic delivery and metabolism in the gut, applied to treat trimethylaminuria by predicting required probiotic doses.

Dietary fiber intervention modulates the formation of the cardiovascular risk factor trimethylamine-N-oxide after beef consumption

This study shows dietary fiber reduces TMAO formation after beef consumption, particularly in low meat eaters, by downregulating cutC expression.

Gut sulfide metabolism modulates behavior and brain bioenergetics

This study shows that gut SQOR deficiency and high dietary methionine impair colon bioenergetics, alter microbiome, and affect brain function and behavior.

Anxiety-like behavior during protracted morphine withdrawal is driven by gut microbial dysbiosis and attenuated with probiotic treatment

This study shows that gut microbial dysbiosis drives anxiety-like behavior during morphine withdrawal and that probiotics can reduce this behavior.

Spotted hyena gut cross-talks:Symbionts modulate mucosal immunity

The paper investigates gut microbiome-mucosal immunity interactions in wild spotted hyenas, finding age-dependent associations and identifying key taxa influencing these relationships.

Methanobrevibacter smithii associates with colorectal cancer through trophic control of the cancer bacteriome

This study identifies Methanobrevibacter smithii as associated with colorectal cancer through trophic interactions with CRC-causing bacteria and archaeal-derived compounds.

LAMPP: A benchmark for continuous evaluation of host phenotype prediction from shotgun metagenomic data

LAMPP provides a standardized benchmark for evaluating host phenotype prediction from gut metagenomic data, showing that traditional methods remain competitive.

VBayesMM: Variational Bayesian neural network to prioritize important relationships of high-dimensional microbiome multiomics data

VBayesMM improves identification of microbial-metabolite relationships in high-dimensional microbiome data by using a Bayesian neural network with spike-and-slab priors.

Deciphering the microbial landscape of lower respiratory tract in health and respiratory diseases

This study characterizes the lung microbiome in health and respiratory diseases using metagenomic sequencing, identifying key species and functional pathways associated with different conditions.

Chenodeoxycholic Acid Modulation via Bacteroides intestinalis AM1 underscores a Novel Approach in Acute Liver Failure

This study identifies elevated chenodeoxycholic acid as a poor prognostic marker in acute liver failure and shows that Bacteroides intestinalis-AM1 reduces bile acids and inflammation, improving liver injury.

Human gut commensal Alistipes timonensis modulates the host lipidome and delivers anti-inflammatory outer membrane vesicles to suppress colitis in an Il10-deficient mouse model

This study shows that Alistipes timonensis colonization in Il10-deficient mice delays colitis by altering the host lipidome and delivering anti-inflammatory outer membrane vesicles containing immunomodulatory lipids.

Establishing an in vitro pipeline for the high-throughput quantification of epithelial permeability of gut bacterial metabolites

This study develops a high-throughput in vitro pipeline to quantify epithelial permeability of gut bacterial metabolites and identifies new bacteria-drug pairs affecting permeability.

Diurnal variations in digestion and luminal flow determine microbial population dynamics along the human large intestine

This study develops a biophysical model to show how diurnal variations in digestion and fluid flow drive microbial population dynamics in the human large intestine, leading to fluctuations in microbial biomass and fermentation product uptake.

Spatial characterization of microbiota profiles along the gut in a widely used mouse model: effects of high-fat diet and fructooligosaccharides

This study characterizes gut microbiota composition along the gastrointestinal tract in mice under high-fat diet and prebiotic conditions, revealing species-specific responses and challenges the translational relevance of rodent models.

Degradation of rutin and genistein and the effect on human bacterial fecal populations of obese and non-obese

This study examines the microbial degradation of rutin and genistein in fecal samples from obese and non-obese individuals, identifying metabolites and microbial shifts linked to health outcomes.

Reduced functional fungal communities in two species of sloths (Bradypus variegatus and Choloepus hoffmanni) suggest a link to slow digestion

This study analyzes the gut microbiota of sloths to link microbial composition and function to their slow digestion.

Fecal Dysosmobacter spp. concentration is linked to plasma lipidome in insulin-resistant individuals with overweight, obesity and metabolic syndrome

Machine learning-based gut microbiota pattern and response to fiber as a diagnostic tool for chronic inflammatory diseases

This study uses machine learning to classify chronic inflammatory diseases based on gut microbiota patterns and response to fiber, achieving up to 95% accuracy in distinguishing between conditions with overlapping dysbiosis.

Growth of Paracoccus aminovorans is restricted by L-ascorbic acid (LA) and human gut isolate

The paper investigates how L-ascorbic acid and co-culture with Weissella confusa restrict the growth of Paracoccus aminovorans, a gut commensal linked to cholera pathogenesis.

Gut colonization by Bacteroides fragilis at juvenile age alters microbiota composition and accelerates type 1 diabetes progression in non-obese diabetic mice

This study shows that early-life colonization by Bacteroides fragilis in NOD mice accelerates type 1 diabetes progression by altering microbiota composition and immune responses.

Metabolic modeling reveals a multi-level deregulation of host-microbiome metabolic networks in IBD

This study uses metabolic modeling to uncover host-microbiome metabolic dysregulation in IBD, identifying key pathways and potential therapeutic interventions.

Dynamic flexibility of the gut microbiota to morphine disturbance enables escape from the stable dysbiosis associated with addiction-like behavior

The paper examines how gut microbiota changes in mice with addiction-like behavior, finding that compulsive morphine use leads to stable dysbiosis while non-compulsive mice show more flexible microbial adaptation.

MICROBIOTA AT THE CROSS ROAD OF DIET AND HEALTH: HOW DIETARY FATS SHAPE BACTERIAL LAND-SCAPE AND INFLUENCE GLOBAL HEALTH

This study investigates how omega-3 fatty acid doses affect gut microbiota composition, immune cells, and metabolic biomarkers in mice fed high-fat diets.

A mathematical framework to correct for compositionality in microbiome datasets

This paper introduces a mathematical framework using internal standards to correct compositional biases in microbiome datasets, improving accuracy and precision in taxa abundance measurements.

Gut3Gel as an in vitro model to investigate dietary modulation of the intestinal microbiota: An inulin supplementation case study

The paper evaluates Gut3Gel as a model to study inulin's effects on the gut microbiota, finding it captures inter-individual responses and prebiotic effects.