Neuroscience and Neuropharmacology Research

Barcoded Rabies In Situ Connectomics for high-throughput reconstruction of neural circuits

The paper introduces BRISC, a method to map neural circuits in the mouse brain using barcoded rabies viruses, identifying synaptic connections in the primary visual cortex.

Neuronal excitability coordinates the timing of input/output circuit assembly

The paper shows that granule cell excitability coordinates the timing of output synapse maturation before input synapse formation in the cerebellum.

Architecture of the Serotonergic Projectome in the Mouse Brain

Whole-brain axon tracing in 110 mouse brains divides raphe serotonin neurons into five projectomic groups, tied to transcriptome plus position and to dissociable behavioral effects of depletion.

Enhanced visual perceptual learning by positive allosteric modulation of α5 subunit-containing GABA-A receptors: putative association with the prelimbic cortex

This study shows that GABRA5 expression in the prelimbic cortex correlates with visual perceptual learning speed and that a GABRA5 modulator improves learning in poor performers.

Differential cortical and thalamic engagement of cholinergic interneurons in the nucleus accumbens core

The paper examines how cortical and thalamic inputs differentially influence cholinergic interneurons in the nucleus accumbens core, showing distinct synaptic properties and receptor contributions.

GABAB Receptors Gate Sex-Specific Synaptic Plasticity in the Nucleus Accumbens

This study shows that GABAB receptor inhibition converts LTP to LTD selectively in female mice at Hipp-NAc synapses, revealing a sex-specific role in synaptic plasticity regulation.

Hindbrain explants enable multimodal and longitudinal analysis of the developing olivo-cerebellar circuit at single-cell resolution

This paper introduces an in vitro model of embryonic mouse hindbrain explants that enables longitudinal, multimodal analysis of olivo-cerebellar circuit development at single-cell resolution.

Ethanol Self-Administration Reduces mGlu2/3 Protein Expression in the Nucleus Accumbens and mGlu2/3 Activation Suppresses Binge Drinking in Male Mice

Synaptic adhesion molecule signaling is activated and organized by tyrosine phosphorylation-induced biomolecular condensate formation

This study identifies tyrosine phosphorylation sites on SYG-1 that drive biomolecular condensate formation, essential for presynapse assembly in C. elegans.

uniSynK: a ratio-optimized bicistronic chemically induced dimerization tool for robust induction of dendritic spine enlargement

The paper develops uniSynK, a single-vector chemogenetic tool that optimizes the expression ratio of two components to robustly induce dendritic spine enlargement with fewer off-target effects.

Loss of Sall3 eliminates presynaptic inhibition of sensory motor circuits and impairs adaptive motor behavior

This study shows that Sall3 is essential for forming GABApre synapses on Ia afferents, and its loss disrupts motor behavior by impairing presynaptic inhibition.

Conditional Deletion of All Neurexins Defines Diversity of Essential Synaptic Organizer Functions for Neurexins

The paper reanalyzes original data and conducts new experiments to show that neurexins have distinct functions in different synapse types.

The Molecular Architecture of Somatic Spines of the Lateral Septum

The paper characterizes the molecular architecture of somatic spines in the lateral septum across developmental stages using imaging techniques and cultured models.

Biased inter-columnar communication and short-term plasticity in mouse barrel cortex

The paper investigates inter-barrel communication in mouse barrel cortex, revealing direction-dependent synaptic circuitry and anisotropy in short-term plasticity.

Native architecture, allosteric modulation and gating mechanism of glycine-dependent NMDA receptors

The paper investigates the structure and gating mechanism of GluN3A-containing NMDA receptors, showing how glycine activates them and how CGP-78608 modulates their activity.

Evolutionary rise of a synaptic mechanism for creating and diversifying key reinforcement signals

The paper shows that GABA co-release in the lateral habenula produces TD-like computations linked to decision-making, and that this mechanism evolved across vertebrates.

Nanoscale Core-Rim Compartmentalization of Histamine and GABA within Individual Synaptic Vesicles

The paper reveals histamine and GABA are spatially segregated within synaptic vesicles, challenging the traditional view of distinct vesicle populations for amino acids and monoamines.

Inhibitory Interneurons Modulate Neurovascular Coupling Primarily Through Indirect Circuit Mechanisms

This study investigates how inhibitory interneurons influence neurovascular coupling during sensory processing in the mouse barrel cortex, finding that their effects are primarily indirect and circuit-based.

Signatures of Hebbian plasticity in the nanoscale morphodynamics of cortical spines

The paper identifies coordinated nanoscale spine remodeling linked to synaptic plasticity using in vivo long-term nanoscopy and data-driven generative models.

Sensory experience drives glutamate spillover, presynaptic LTP and functional connectome remodeling in the barrel cortex

The paper shows that sensory experience increases glutamate release and strengthens synaptic connections in the barrel cortex, leading to changes in the functional connectome.

Developmental NMDA receptor signaling regulates cerebellar unipolar brush cell number and dampens excitability

This study investigates the role of NMDA receptor signaling in the development and function of cerebellar unipolar brush cells, finding that NMDARs are not essential for dendritic development but may regulate cell death and excitability.

Subthreshold membrane depolarization powerfully engages intracellular calcium dynamics in the awake mammalian brain

The paper investigates how subthreshold membrane depolarization influences intracellular calcium dynamics in awake mice, showing strong coupling during prolonged depolarization and weaker coupling during isolated spikes.

Intracellular Regulation of a Serotonin-Gated Ion Channel Links Receptor Trafficking to Memory

The paper identifies an intracellular motif in the serotonin-gated ion channel LGC-50 that links receptor trafficking to memory stability in C. elegans.

Glutamatergic synaptic inhibition through group II mGluR-mediated suppression of the sodium leak channel NALCN

The paper investigates how group II mGluRs modulate the sodium leak channel NALCN in cerebellar unipolar brush cells, revealing a novel mechanism of glutamatergic synaptic inhibition.

WNK-Dependent Phosphorylation of Gephyrin Tunes GABAA Receptors at Inhibitory Synapses and Modulates Anxiety Behavior

This study identifies a WNK-dependent phosphorylation mechanism that regulates GABAAR stability and synaptic function, leading to altered anxiety behavior in mice.

Elucidating the Role of Cerebellar Nuclei Parvalbumin Activity on Adolescent Reversal Learning

This study investigates the role of cerebellar nuclei parvalbumin activity in adolescent reversal learning using DREADDs and Hapln1-AAV vectors in mice.

Paratenial thalamus engages in reciprocal and broadcast circuits with the prefrontal cortex

The paper identifies reciprocal and broadcast neural circuits between the paratenial thalamus and the prefrontal cortex using molecular profiling, anatomical tracing, and electrophysiology.

SRGAP2 limits experience-dependent structural synaptic plasticity in adult cortical circuits

This study shows that SRGAP2 limits experience-dependent structural synaptic plasticity in adult cortical circuits, with its deletion increasing plasticity in mice and suggesting a role for human-specific paralogs in human neurons.

Cholecystokinin released somatodendritically from dopamine neurons broadly alters synaptic strength across the ventral tegmental area

The paper shows that somatodendritic release of cholecystokinin from dopamine neurons in the VTA alters synaptic strength, both at GABAergic and glutamatergic synapses, and influences neighboring neurons.

Tuft dendrite spikes are accompanied by selective input from distinct functional networks

The paper investigates how tuft dendritic spikes in layer 5 neurons are associated with specific synaptic activity patterns and functional network inputs during a behavioral task.