DNA Repair Mechanisms

This study identifies how ATM deficiency leads to PARPi sensitivity through replication defects caused by oxidative base damage and impaired fork reversal.

This study shows that RAD51 accumulates on non-damaged chromosomes in aging oocytes, leading to chromosome segregation failure and meiosis I arrest.

This study shows that microhomology-mediated end joining (MMEJ) repairs single-ended DSBs at replication forks, working with BIR and being regulated by ATR and Pol{theta}.

The paper shows that Top3 activity moves Holliday junctions from Spo11 hotspots to convergent transcription sites, where crossover resolution occurs during meiosis.

This study identifies ROS-DPCs in human cells and shows that the ubiquitin-proteasomal system, SPRTN, and NER remove them, with a GSH analog preventing their formation.

This study presents cryo-EM structures of yeast NHEJ complexes, revealing mechanisms for DNA-end protection and ligation without DNA-PKcs.

This study identifies BRCA1-A and LIG4 complexes as mediators of ecDNA biogenesis and shows their role in cancer drug resistance.

This study identifies KLHDC3 as a rescue factor for RECQL4 mutations, showing that low levels of a truncated RECQL4 protein can support DNA replication without requiring its ATPase or helicase domains.

This study uses CRISPR screening to map genetic interactions in homologous recombination sub-pathways, revealing roles of RAD54L, RAD51AP1, RAD54B, and TOP3A in pathway choice and function.

This study identifies USP7 as a stabilizer of FAN1, showing its role in DNA crosslink repair and suppression of CAG repeat expansion in Huntington's disease.

This study identifies the INO80-EEN complex's role in preventing structural rearrangements at protein coding genes in Arabidopsis under UV-B exposure.

This study uses optical tweezers to analyze XPD helicase dynamics on DNA lesions, revealing distinct damage-sensing behaviors and identifying two XPD regions sensitive to DNA modifications.

This study identifies Nlrp6 as a regulator of DNA repair and epithelial regeneration in intestinal crypts, linking DNA damage responses to colorectal cancer progression.

The paper models DNA replication fork stability using chromatin fiber analysis and the R-ODD-BLOBS program, showing changes in fork length and protein localization in different genetic backgrounds.

This study shows that RPA1 is critical for DNA damage repair in oocytes, leading to infertility when disrupted.

This paper identifies two distinct MUS81 inhibitors that enhance chemotherapy efficacy by impairing DNA repair in cancer cells.

The paper models how Tel1-mediated feedback shapes Spo11-DSB formation in yeast, showing local inhibition leads to genome-wide DSB redistribution.

This study shows that BLM helicase is essential for resolving ultrafine DNA bridges during mitosis, preventing genomic instability.

This study shows that deficiencies in Fanconi Anemia or homologous recombination pathways enhance the antitumor effects of CP-506, a hypoxia-activated prodrug, through synthetic lethality mechanisms.

The paper shows that AT/TA repeats form DNA structures that are processed by nucleases and repositioned to the nuclear periphery for repair.

This study presents a cryo-EM structure of the human CTF18-RFC complex bound to PCNA, revealing structural features important for PCNA loading and Pol ε-mediated leading strand synthesis.

The paper shows that defective BRCA1-mediated DNA end resection leads to Group 1 tandem duplication formation and FANCM synthetic lethality in mouse models.

This study tracks DNA damage and chromatin remodeling in live cells using Hoechst-based imaging, showing PARP1 dynamics and chromatin relaxation kinetics.

The paper investigates how MRE11 suppresses germline mutagenesis at meiotic double-strand breaks in mice by analyzing the effects of DSB processing and end joining.

The paper shows PTBP2 stabilizes Pol{kappa} mRNA, leading to genomic instability in CML cells by interacting with MRE11 and promoting DNA damage.

This study identifies SFPQ as a factor promoting homologous recombination by stabilizing RAD51 and its paralogs' mRNA, independent of DSB localization or p53 activation.

The paper studies mutations and structural variants during double-strand break repair in budding yeast, finding that repair-associated deletions and template switches depend on microhomology and homeology.

This paper identifies small molecule agonists of OGG1 that enhance its catalytic activity and reduce oxidative stress in OGG1-deficient cells.

This study identifies the glycine-arginine-rich motif of 53BP1 as essential for RNA interactions and phase separation during DNA damage response, showing its role in DNA repair.

This study identifies a type I interferon signaling signature in XPC-deficient keratinocytes, linking UVB exposure to JAK/STAT pathway dysregulation and hypersensitivity.