DNA Repair Mechanisms

The paper investigates the mutational impact of ionizing radiation on normal cells and confirms these signatures in IR-induced cancers.

This study shows that Dot1L-dependent H3K79 methylation is essential for efficient HDR of DNA double strand breaks and genomic stability.

This study shows that a zebrafish DNA polymerase mutation leads to DNA damage, S phase arrest, and cell death over time, with effects varying by cell type and replication rate.

This study identifies TENT4A as a regulator of DNA-damage tolerance through multiple pathways, with mutations in these pathways linked to endometrial cancer.

This study shows that phospho-mimetic H2A-S129E increases chromatin mobility and modulates DNA damage response by altering chromosomal conformation.

The paper identifies a non-canonical role of DNA mismatch repair (MMR) in repairing methylation damage in non-dividing cells, contributing to mutational signatures in cancer.

The paper shows that uncoordinated BER activity at DNA lesions causes DSB accumulation in yeast exposed to Zeocin, leading to genomic fragmentation.

The paper reports that frameshift mutations in E. coli are repaired through a process called nonsense-mediated gene revising, which increases genetic diversity and accelerates evolution.

This study overexpresses MutS in E. coli, revealing impaired DNA mismatch repair and cell division defects linked to MutS-FtsZ interaction.

This study uses electron microscopy to analyze replication intermediates in UV-irradiated human cells, revealing the role of pol{eta} and RAD51 in DNA damage tolerance mechanisms.

This study shows that aberrant replication licensing factors drive Copy Number Gains (CNGs) in fission yeast and mammalian cells, linking re-replication to cancer and evolution.

This study shows FANCD2 reduces replication stress in fetal liver HSC, preventing excessive RPA-coated ssDNA and pChk1 activation.

The paper investigates how meiotic DNA replication patterns influence recombination landscapes in mammals, finding a strong correlation between replication origin density and recombination potential.

The paper shows RNA alkylation triggers recruitment of the ASCC repair complex via RNF113A, revealing RNA damage as a signal for DNA repair.

The paper investigates the role of phase partitioning in DNA damage response by analyzing APE1's interactome for signs of liquid-liquid phase separation.

The paper shows that inherited broken chromosomes in S. pombe undergo cycles of replication and processing, leading to chromosomal instability and rearrangements.

The paper shows that mutant CARD14 proteins induce DNA double-strand breaks under replication stress, leading to homologous recombination and reversion of pathogenic mutations in genetic skin diseases.

The paper develops a theory of optimal checkpoint strategies to predict DNA damage checkpoint override times in yeast, validated with single-cell experiments.

This study identifies impaired homologous recombination in SDS and DBA patient-derived cells, linking ribosomopathy genes to DNA repair defects and suggesting PARP inhibition as a potential therapeutic target.

The paper investigates the in vivo localization of Msh5 during meiosis in yeast, showing its association with DSB hotspots, chromosome axis, and centromeres, and its role in promoting crossover formation.

This study identifies USP11 as a deubiquitinase that regulates SPRTN function in DNA-protein crosslink repair by removing monoubiquitin from SPRTN.

The paper shows that DNA double-strand breaks in mouse oocytes can induce BIR and amplification, with repair efficiency affected by sequence similarity and chromatin configuration.

This paper introduces circle-damage-seq, a method to map DNA damage at nucleotide resolution genome-wide, demonstrating its application to UVB-induced CPDs and 4-hydroxynonenal-induced adducts.

The paper develops a targeted sequencing approach to analyze mutation profiles in yeast and identifies genotype-specific variants influenced by dNTP pool changes.

This study identifies that phosphorylation of Rif1 by checkpoint kinases protects nascent DNA from degradation by Sgs1-Dna2 in budding yeast, highlighting a conserved mechanism for genome stability.

This study shows TIP60 acetylates H2AZ, affecting DNA repair gene expression and doxorubicin sensitivity through RAD51 transcription.

The paper analyzes mutational spectra in C. elegans DNA repair mutants to identify how different repair pathways affect mutagenesis in germ cells.

This study shows that DNMT3b dysfunction leads to centromere instability through R-loop-mediated DNA breaks and XPG/XPF cleavage.

This study identifies BARD1's role in recruiting BRCA1 to DNA damage sites via H2AK15ub binding, linking it to HR and pathway choice.

This study identifies PrimPol as a key player in ICL traverse, showing its primase activity is required for DNA damage tolerance and that its absence increases sensitivity to ICL-inducing drugs.